Details of the Target

General Information of Target

Target ID LDTP06985
Target Name Meckelin (TMEM67)
Gene Name TMEM67
Gene ID 91147
Synonyms
MKS3; Meckelin; Meckel syndrome type 3 protein; Transmembrane protein 67
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MATRGGAGVAMAVWSLLSARAVTAFLLLFLPRFLQAQTFSFPFQQPEKCDNNQYFDISAL
SCVPCGANQRQDARGTSCVCLPGFQMISNNGGPAIICKKCPENMKGVTEDGWNCISCPSD
LTAEGKCHCPIGHILVERDINGTLLSQATCELCDGNENSFMVVNALGDRCVRCEPTFVNT
SRSCACSEPNILTGGLCFSSTGNFPLRRISAARYGEVGMSLTSEWFAKYLQSSAAACWVY
ANLTSCQALGNMCVMNMNSYDFATFDACGLFQFIFENTAGLSTVHSISFWRQNLPWLFYG
DQLGLAPQVLSSTSLPTNFSFKGENQNTKLKFVAASYDIRGNFLKWQTLEGGVLQLCPDT
ETRLNAAYSFGTTYQQNCEIPISKILIDFPTPIFYDVYLEYTDENQHQYILAVPVLNLNL
QHNKIFVNQDSNSGKWLLTRRIFLVDAVSGRENDLGTQPRVIRVATQISLSVHLVPNTIN
GNIYPPLITIAYSDIDIKDANSQSVKVSFSVTYEMDHGEAHVQTDIALGVLGGLAVLASL
LKTAGWKRRIGSPMIDLQTVVKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLL
PMPIQEERFVTYVGCAFALKALQFLHKLISQITIDVFFIDWERPKGKVLKAVEGEGGVRS
ATVPVSIWRTYFVANEWNEIQTVRKINSLFQVLTVLFFLEVVGFKNLALMDSSSSLSRNP
PSYIAPYSCILRYAVSAALWLAIGIIQVVFFAVFYERFIEDKIRQFVDLCSMSNISVFLL
SHKCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFEIAISNQMR
QHYDRIHETLIRKNGPARLLSSSASTFEQSIKAYHMMNKFLGSFIDHVHKEMDYFIKDKL
LLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIFDLLFFCVVDLACQNFILA
SFLTYLQQEIFRYIRNTVGQKNLASKTLVDQRFLI
Target Bioclass
Transporter and channel
Subcellular location
Cell membrane
Function
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Is a key regulator of stereociliary bundle orientation. Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A. In non-canonical Wnt signaling, it may act as ROR2 coreceptor.
Uniprot ID
Q5HYA8
Ensemble ID
ENST00000323130.8
HGNC ID
HGNC:28396

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C817(1.12)  LDD3315  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C770(0.80)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C817(0.95)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C770(1.07); C817(1.01)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C770(1.10)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C770(1.41); C817(1.09)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C770(1.08); C817(1.00)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C770(0.79)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C817(1.14)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C770(0.73); C817(1.01)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C817(1.03)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C770(1.04)  LDD1519  [2]
 LDCM0282  AC22 HEK-293T C770(1.49); C817(1.01)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C770(1.15); C817(1.05)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C817(1.00)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C770(0.81)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C817(1.17)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C770(0.90); C817(1.01)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C770(1.07)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C770(1.33); C817(1.01)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C770(1.12); C817(0.93)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C770(1.40); C817(1.29)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C817(0.88)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C770(1.13)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C817(0.96)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C770(1.08); C817(1.06)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C770(1.11)  LDD1536  [2]
 LDCM0299  AC38 HEK-293T C770(1.18); C817(0.97)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C770(1.13); C817(1.08)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C770(0.90)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C817(0.93)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C770(1.03)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C817(1.25)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C770(0.88); C817(1.12)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C770(0.87)  LDD1545  [2]
 LDCM0308  AC46 HEK-293T C770(1.05); C817(0.97)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C770(0.90); C817(1.05)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C817(1.05)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C770(1.18)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C817(1.12)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C770(0.90); C817(1.03)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C770(1.22)  LDD1554  [2]
 LDCM0317  AC54 HEK-293T C770(1.17); C817(1.00)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C770(0.98); C817(1.02)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C817(1.04)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C770(1.00)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C817(1.05)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C770(1.21); C817(1.03)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C770(1.18); C817(0.79)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C770(1.11)  LDD1563  [2]
 LDCM0326  AC62 HEK-293T C770(1.27); C817(1.09)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C770(1.13); C817(1.18)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C817(0.92)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C770(0.94); C817(0.96)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C817(0.94)  LDD1569  [2]
 LDCM0356  AKOS034007680 HEK-293T C770(0.82)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C817(1.05)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C770(0.14)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C770(1.12); C817(0.90)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C770(1.25)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C770(1.11)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C770(0.76)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C770(1.02)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C770(0.79)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C770(1.03); C817(1.01)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C770(1.07)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C770(1.24)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C770(1.35)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C770(1.01)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C770(0.95)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C817(0.95)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C770(1.28)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C770(0.56)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C770(1.19)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C770(1.04)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C770(1.08)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C770(1.08)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C770(0.88)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C817(0.93)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C770(1.11); C817(1.01)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C770(1.54)  LDD1612  [2]
 LDCM0410  CL22 HEK-293T C770(1.26); C817(0.94)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C770(1.55); C817(1.04)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C817(1.05)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C770(0.73)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C770(1.21)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C770(0.75)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C770(1.10)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C817(0.93)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C770(0.87); C817(1.02)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C770(1.02)  LDD1625  [2]
 LDCM0423  CL34 HEK-293T C770(1.17); C817(0.92)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C770(1.27); C817(0.87)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C817(1.04)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C770(1.33)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C770(1.12)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C770(0.74)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C817(1.05)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C770(0.91); C817(1.02)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C770(1.23)  LDD1638  [2]
 LDCM0436  CL46 HEK-293T C770(0.95); C817(0.91)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C770(1.11); C817(1.00)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C817(1.07)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C770(1.29)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C770(1.03)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C770(0.84)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C817(1.09)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C770(1.07); C817(0.96)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C770(1.42)  LDD1650  [2]
 LDCM0449  CL58 HEK-293T C770(1.18); C817(0.95)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C770(1.48); C817(1.04)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C817(1.16)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C817(1.07)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C770(1.22)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C770(0.96)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C770(0.84)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C817(1.17)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C770(1.17); C817(0.95)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C770(0.63)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C770(1.00); C817(1.01)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C770(1.39); C817(0.94)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C770(1.42); C817(1.12)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C817(1.03)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C770(1.14)  LDD1669  [2]
 LDCM0470  CL77 HEK-293T C770(0.89)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C817(1.05)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C770(0.90); C817(1.00)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C770(1.09)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C770(1.14)  LDD1677  [2]
 LDCM0476  CL82 HEK-293T C770(1.08); C817(0.84)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C770(1.19); C817(0.95)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C817(0.98)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C770(0.87)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C770(1.13)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C770(1.16)  LDD1686  [2]
 LDCM0485  CL90 HEK-293T C817(1.17)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C770(1.13); C817(0.98)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C770(1.00)  LDD1690  [2]
 LDCM0489  CL94 HEK-293T C770(1.37); C817(1.00)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C770(0.96); C817(1.23)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C817(0.97)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C770(1.35)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C770(1.17)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C770(1.11)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C770(1.18)  LDD1671  [2]
 LDCM0022  KB02 HEK-293T C817(1.08)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C817(0.90)  LDD1497  [2]
 LDCM0024  KB05 IGR39 C817(1.12)  LDD3315  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402