Details of the Target

General Information of Target

Target ID LDTP06909
Target Name Akirin-2 (AKIRIN2)
Gene Name AKIRIN2
Gene ID 55122
Synonyms
C6orf166; Akirin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAAASPLSAAAATAASFSAAAASPQK
YLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLETSFQQTDPCCTSDAQPHAFLL
SGPASPGTSSAASSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYD
AFVKFTHDQIMRRYGEQPASYVS
Target Bioclass
Other
Family
Akirin family
Subcellular location
Nucleus
Function
Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development. Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore. Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors. Also plays a role in facilitating interdigital tissue regression during limb development.
Uniprot ID
Q53H80
Ensemble ID
ENST00000257787.6
HGNC ID
HGNC:21407

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.79  LDD0403  [1]
IA-alkyne
 Probe Info  		C27(20.00)  LDD1710  [2]
DBIA
 Probe Info  		C152(0.72)  LDD0533  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		C27(0.00); C3(0.00)  LDD0147  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C152(0.72)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C152(0.75)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C152(0.80)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C152(1.03)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C152(0.87)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C152(0.76)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C152(0.62)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C152(0.76)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C152(0.64)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C152(0.76)  LDD0542  [3]
 LDCM0227  AC110 HCT 116 C152(0.65)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C152(0.66)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C152(0.68)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C152(0.89)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C152(0.71)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C152(1.08)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C152(1.22)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C152(1.04)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C152(0.85)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C152(1.35)  LDD0553  [3]
 LDCM0238  AC120 HCT 116 C152(1.37)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C152(0.86)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C152(1.03)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C152(0.75)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C152(0.70)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C152(0.90)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C152(1.16)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C152(0.93)  LDD0562  [3]
 LDCM0263  AC143 HCT 116 C152(1.02)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C152(0.96)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C152(1.05)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C152(0.95)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C152(1.34)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C152(1.74)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C152(1.35)  LDD0586  [3]
 LDCM0271  AC150 HCT 116 C152(0.99)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C152(0.90)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C152(0.99)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C152(1.80)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C152(1.38)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C152(0.83)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C152(0.68)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C152(0.63)  LDD2161  [3]
 LDCM0285  AC25 HCT 116 C152(1.11)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C152(1.88)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C152(1.47)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C152(1.69)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C152(0.93)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C152(1.46)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C152(1.41)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C152(1.95)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C152(0.99)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C152(1.38)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C152(1.31)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C152(1.65)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C152(1.27)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C152(1.16)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C152(2.21)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C152(1.16)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C152(1.56)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C152(2.15)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C152(2.00)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C152(0.97)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C152(2.42)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C152(0.89)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C152(0.73)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C152(1.46)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C152(1.86)  LDD0628  [3]
 LDCM0313  AC50 HCT 116 C152(1.68)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C152(0.78)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C152(1.09)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C152(1.09)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C152(1.58)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C152(1.22)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C152(1.74)  LDD0636  [3]
 LDCM0349  AC83 HCT 116 C152(1.91)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C152(1.41)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C152(1.17)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C152(1.10)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C152(0.93)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C152(0.95)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C152(1.15)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C152(1.03)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C152(1.82)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C152(1.48)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C152(0.84)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C152(1.25)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C152(0.84)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C152(1.09)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C152(1.34)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C152(1.28)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C152(0.67)  LDD0683  [3]
 LDCM0156  Aniline NCI-H1299 14.79  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C27(0.97)  LDD2227  [8]
 LDCM0382  CL112 HCT 116 C152(1.45)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C152(0.92)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C152(1.01)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C152(1.05)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C152(1.84)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C152(2.76)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C152(1.53)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C152(2.09)  LDD0706  [3]
 LDCM0391  CL120 HCT 116 C152(2.32)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C152(0.68)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C152(2.03)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C152(1.16)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C152(1.38)  LDD0712  [3]
 LDCM0024  KB05 T cell-activated C27(20.00)  LDD1710  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Akirin-2 (AKIRIN2) Akirin family Q53H80
LRP chaperone MESD (MESD) MESD family Q14696
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Vinexin (SORBS3) . O60504

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264