Details of the Target

General Information of Target

Target ID LDTP06829
Target Name Coiled-coil domain-containing protein 14 (CCDC14)
Gene Name CCDC14
Gene ID 64770
Synonyms
Coiled-coil domain-containing protein 14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQVL
SSGRHTGPAKLTNGKKATYLRKIPRFNADSGYSIHSDSESQAETVHGLDGCASLLRDILR
NEDSGSETAYLENRSNSRPLESKRYGSKKKRHEKHTIPLVVQKETSSSDNKKQIPNEASA
RSERDTSDLEQNWSLQDHYRMYSPIIYQALCEHVQTQMSLMNDLTSKNIPNGIPAVPCHA
PSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQTDGNSQFASQGKTVSATCTDV
LRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFRS
HGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQK
AKNVNKTAEKVRIIKYLLGELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEI
ALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEE
SLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEE
ALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSAR
CKPGNNLTKSLLNIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEP
DKTYENVLSSRGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYI
PFARSTPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICSSSTKEAED
APEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTVCD
GSVFTSDLMSDWSISSFSTFTSRDEQDFRNGLAALDANIARLQKSLRTGLLEK
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Function Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.
Uniprot ID
Q49A88
Ensemble ID
ENST00000485727.5
HGNC ID
HGNC:25766

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C826(1.08); C831(1.08); C880(0.97); C886(0.97)  LDD0078  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]
TFBX
 Probe Info  		C297(0.00); C313(0.00)  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C826(1.02); C831(1.02)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C350(0.94)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C350(0.92)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C350(1.70)  LDD1512  [3]
 LDCM0263  AC143 HEK-293T C297(1.09)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C297(1.19)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C297(1.13)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C297(1.05)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C297(1.19)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C297(1.13)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C297(1.01)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C350(0.75)  LDD1513  [3]
 LDCM0271  AC150 HEK-293T C297(0.98)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C297(1.09)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C297(1.01)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C297(1.16)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C297(1.04)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C297(1.15)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C297(1.28)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C297(1.49)  LDD2165  [1]
 LDCM0277  AC18 HEK-293T C826(0.86); C831(0.86)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C350(1.09)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C826(1.19); C831(1.19)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C350(1.12)  LDD1519  [3]
 LDCM0282  AC22 HEK-293T C350(1.01)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C350(0.96)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C297(1.23)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C297(1.30)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C297(1.34)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C297(2.05)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C297(1.37)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C350(0.79)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C297(1.21)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C297(1.88)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C297(1.67)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C297(1.52)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C297(2.11)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C350(0.90)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C350(1.06)  LDD1536  [3]
 LDCM0299  AC38 HEK-293T C350(1.06)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C350(0.96)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C350(1.22)  LDD1540  [3]
 LDCM0304  AC42 HEK-293T C826(0.89); C831(0.89)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C350(1.34)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C350(0.99)  LDD1545  [3]
 LDCM0308  AC46 HEK-293T C297(1.18)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C297(1.28)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C297(0.98)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C297(1.07)  LDD0909  [1]
 LDCM0313  AC50 HEK-293T C297(1.20)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C297(1.19)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C297(1.14)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C297(1.48)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C297(1.04)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C297(1.18)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C297(0.91)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C297(0.70)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C297(0.76)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C297(0.64)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C350(1.29)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C297(1.27)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C297(0.88)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C297(0.70)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C297(0.91)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C297(0.91)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C297(0.84)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C297(0.96)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C297(0.92)  LDD0929  [1]
 LDCM0334  AC7 HEK-293T C350(0.95)  LDD1568  [3]
 LDCM0349  AC83 HEK-293T C297(0.81)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C297(1.09)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C297(0.86)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C297(1.05)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C297(0.96)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C297(1.05)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C297(1.07)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C297(0.96)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C297(0.97)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C297(0.98)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C297(1.26)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C297(1.25)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C297(1.11)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C297(0.99)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C297(1.23)  LDD0962  [1]
 LDCM0020  ARS-1620 HCC44 C826(1.08); C831(1.08); C880(0.97); C886(0.97)  LDD0078  [1]
 LDCM0368  CL10 HEK-293T C350(1.25)  LDD1572  [3]
 LDCM0371  CL102 HEK-293T C297(1.12); C350(1.10)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C297(1.08)  LDD1576  [3]
 LDCM0375  CL106 HEK-293T C297(1.15); C350(0.68)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C297(0.96)  LDD1580  [3]
 LDCM0379  CL11 HEK-293T C350(0.82)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C297(1.41); C350(1.04)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C297(1.20)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C297(1.41)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C297(1.37)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C297(1.48)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C297(1.84)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C297(1.69)  LDD0984  [1]
 LDCM0388  CL118 HEK-293T C297(1.01); C350(1.33)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C297(1.11)  LDD1593  [3]
 LDCM0392  CL121 HEK-293T C297(1.23)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C297(1.09)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C297(1.00)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C297(1.21)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C297(0.82)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C297(0.61)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C297(0.84)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C297(0.72)  LDD0997  [1]
 LDCM0401  CL14 HEK-293T C297(1.28); C350(0.90)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C297(1.36)  LDD1606  [3]
 LDCM0405  CL18 HEK-293T C826(1.22); C831(1.22)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C350(1.04)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C297(1.38); C350(0.96)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C350(0.73)  LDD1612  [3]
 LDCM0410  CL22 HEK-293T C350(1.46)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C350(0.61)  LDD1615  [3]
 LDCM0414  CL26 HEK-293T C297(1.04); C350(1.16)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C297(1.02)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C297(1.23)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C826(0.99); C831(0.99)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C350(0.88)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C350(0.79)  LDD1625  [3]
 LDCM0423  CL34 HEK-293T C350(0.71)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C350(0.73)  LDD1628  [3]
 LDCM0428  CL39 HEK-293T C297(1.06)  LDD1632  [3]
 LDCM0432  CL42 HEK-293T C826(0.91); C831(0.91)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C350(1.11)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C350(0.78)  LDD1638  [3]
 LDCM0436  CL46 HEK-293T C350(1.21)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C350(0.89)  LDD1641  [3]
 LDCM0441  CL50 HEK-293T C297(1.18); C350(1.27)  LDD1645  [3]
 LDCM0445  CL54 HEK-293T C826(0.86); C831(0.86)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C350(0.99)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C350(0.97)  LDD1650  [3]
 LDCM0449  CL58 HEK-293T C350(0.98)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C350(1.16)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C826(1.12); C831(1.12)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C297(0.75)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C297(0.85)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C297(0.74)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C297(0.78)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C297(0.82)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C297(0.75)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C297(0.85)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C297(1.04)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C297(0.82)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C350(0.86)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C297(0.87)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C297(1.20)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C297(1.04)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C297(0.95)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C297(1.07)  LDD1065  [1]
 LDCM0471  CL78 HEK-293T C826(1.09); C831(1.09)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C350(1.02)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C350(1.25)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C350(0.77)  LDD1677  [3]
 LDCM0476  CL82 HEK-293T C350(1.26)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C350(0.73)  LDD1680  [3]
 LDCM0480  CL86 HEK-293T C297(1.13); C350(1.40)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C297(1.17)  LDD1684  [3]
 LDCM0485  CL90 HEK-293T C826(1.05); C831(1.05)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C350(0.80)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C350(0.72)  LDD1690  [3]
 LDCM0489  CL94 HEK-293T C350(1.06)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C350(1.05)  LDD1693  [3]
 LDCM0493  CL98 HEK-293T C297(1.10); C350(1.60)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C297(1.09)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C297(1.32)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C297(1.00)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C297(1.09); C350(0.79)  LDD1631  [3]
 LDCM0022  KB02 HCT 116 C826(2.32); C831(2.32)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C826(1.80); C831(1.80)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C826(2.72); C831(2.72)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Casein kinase I isoform delta (CSNK1D) CK1 Ser/Thr protein kinase family P48730
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pericentriolar material 1 protein (PCM1) PCM1 family Q15154
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 63 kDa (CEP63) CEP63 family Q96MT8
Peroxisomal targeting signal 1 receptor (PEX5) Peroxisomal targeting signal receptor family P50542
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Gelsolin (GSN) Villin/gelsolin family P06396
Melanoma-associated antigen 11 (MAGEA11) . P43364
Melanoma-associated antigen B4 (MAGEB4) . O15481

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402