Details of the Target

General Information of Target

Target ID LDTP06263
Target Name HUWE1-associated protein modifying stress responses 1 (HAPSTR1)
Gene Name HAPSTR1
Gene ID 29035
Synonyms
C16orf72; TAPR1; HUWE1-associated protein modifying stress responses 1; Telomere attrition and p53 response 1 protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEERKEEGEAEIQEHGPEHWFSKWERQCLAEAEQDEQLPPELQEEAAAAAQPEHKQQKLW
HLFQNSATAVAQLYKDRVCQQPGLSLWVPFQNAATAVTNLYKESVDTHQRSFDIGIQIGY
QRRNKDVLAWVKKRRRTIRREDLISFLCGKVPPPRNSRAPPRLTVVSPNRATSTETSSSV
ETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSSGSNASRRRNGLHDVDLNTFISE
EMALHLDNGGTRKRTSAQCGDVITDSPTHKRNRMI
Target Bioclass
Other
Family
HAPSTR1 family
Subcellular location
Nucleus
Function
Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1.
Uniprot ID
Q14CZ0
Ensemble ID
ENST00000327827.12
HGNC ID
HGNC:30103

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C148(0.82)  LDD0531  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C148(0.82)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C148(1.18)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C148(1.55)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C148(1.48)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C148(1.28)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C148(1.02)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C148(1.27)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C148(1.05)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C148(1.25)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C148(0.93)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C148(1.10)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C148(1.07)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C148(1.00)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C148(1.01)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C148(1.25)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C148(0.93)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C148(0.92)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C148(0.86)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C148(1.02)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C148(0.92)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C148(0.89)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C148(1.00)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C148(1.00)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C148(1.03)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C148(0.95)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C148(1.02)  LDD0612  [1]
 LDCM0301  AC4 HCT 116 C148(0.98)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C148(1.06)  LDD0629  [1]
 LDCM0320  AC57 HCT 116 C148(1.14)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C148(1.11)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C148(0.93)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C148(0.84)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C148(0.99)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C148(1.04)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C148(1.00)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C148(1.03)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C148(1.02)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C148(1.03)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C148(1.18)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C148(1.03)  LDD0648  [1]
 LDCM0334  AC7 HCT 116 C148(0.80)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C148(0.96)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C148(0.84)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C148(0.80)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C148(0.85)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C148(0.89)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C148(1.00)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C148(0.95)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C148(0.85)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C148(1.04)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C148(0.93)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C148(0.91)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C148(0.92)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C148(1.03)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C148(0.97)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C148(0.96)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C148(0.94)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C148(1.47)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C148(0.98)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C148(1.20)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C148(0.73)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C148(1.63)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C148(0.89)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C148(0.81)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C148(1.13)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C148(1.31)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C148(1.20)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C148(1.01)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C148(1.12)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C148(1.11)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C148(1.07)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C148(1.00)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C148(1.72)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C148(1.13)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C148(1.04)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C148(0.98)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C148(0.93)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C148(0.80)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C148(0.83)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C148(0.87)  LDD0703  [1]
 LDCM0390  CL12 HCT 116 C148(1.81)  LDD0707  [1]
 LDCM0396  CL125 HCT 116 C148(1.04)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C148(0.76)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C148(0.79)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C148(0.97)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C148(0.94)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C148(0.85)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C148(0.99)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C148(0.84)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C148(0.68)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C148(0.81)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C148(0.89)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C148(0.78)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C148(0.79)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C148(0.86)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C148(0.88)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C148(1.01)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C148(0.96)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C148(0.93)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C148(0.89)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C148(0.90)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C148(0.90)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C148(0.90)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C148(1.08)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C148(1.01)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C148(0.91)  LDD0737  [1]
 LDCM0429  CL4 HCT 116 C148(0.93)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C148(1.08)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C148(0.77)  LDD0768  [1]
 LDCM0462  CL7 HCT 116 C148(1.42)  LDD0779  [1]
 LDCM0469  CL76 HCT 116 C148(0.97)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C148(0.68)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C148(0.96)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C148(0.90)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C148(0.52)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C148(0.97)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C148(0.93)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C148(0.97)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C148(0.89)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C148(0.96)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C148(0.81)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C148(0.96)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C148(0.79)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C148(0.98)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C148(1.02)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C148(1.04)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C148(0.73)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C148(0.83)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C148(0.84)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C148(0.65)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C148(0.79)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C148(0.94)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C148(0.94)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C148(0.80)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C148(0.66)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C148(0.81)  LDD0811  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264