Details of the Target

General Information of Target

Target ID LDTP06136
Target Name Sodium channel protein type 5 subunit alpha (SCN5A)
Gene Name SCN5A
Gene ID 6331
Synonyms
Sodium channel protein type 5 subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5; hH1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ
PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily
Subcellular location
Cell membrane
Function
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.
TTD ID
T39716
Uniprot ID
Q14524
DrugMap ID
TTZOVE0
Ensemble ID
ENST00000327956.7
HGNC ID
HGNC:10593
ChEMBL ID
CHEMBL1980

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C373(0.23)  LDD1093  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C373(0.23)  LDD1093  [1]
 LDCM0263  AC143 PaTu 8988t C373(1.28)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C373(0.67)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C373(0.75)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C373(0.64)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C373(1.10)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C373(0.98)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C373(1.37)  LDD1148  [1]
 LDCM0271  AC150 PaTu 8988t C373(0.93)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C373(0.62)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C373(0.91)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C373(0.68)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C373(0.67)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C373(0.94)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C373(0.72)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C373(0.63)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C373(1.12)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C373(1.19)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C373(1.15)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C373(0.24)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C373(1.14)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C373(1.10)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C373(1.12)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C373(1.53)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C373(1.14)  LDD1163  [1]
 LDCM0285  AC25 PaTu 8988t C373(0.97)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C373(0.92)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C373(0.98)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C373(0.96)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C373(1.05)  LDD1168  [1]
 LDCM0290  AC3 PaTu 8988t C373(0.28)  LDD1169  [1]
 LDCM0291  AC30 PaTu 8988t C373(1.18)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C373(0.77)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C373(1.08)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C373(1.12)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C373(1.15)  LDD1174  [1]
 LDCM0296  AC35 PaTu 8988t C373(0.99)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C373(0.70)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C373(0.72)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C373(0.95)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C373(0.71)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C373(0.20)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C373(0.79)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C373(0.63)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C373(0.65)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C373(0.78)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C373(0.55)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C373(0.89)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C373(1.02)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C373(0.86)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C373(0.94)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C373(1.14)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C373(0.19)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C373(1.11)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C373(0.38)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C373(1.07)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C373(1.44)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C373(0.90)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C373(1.03)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C373(1.36)  LDD1198  [1]
 LDCM0320  AC57 PaTu 8988t C373(1.89)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C373(1.78)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C373(2.58)  LDD1201  [1]
 LDCM0324  AC60 PaTu 8988t C373(2.12)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C373(1.80)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C373(2.13)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C373(1.73)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C373(1.53)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C373(2.07)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C373(1.94)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C373(1.81)  LDD1210  [1]
 LDCM0349  AC83 PaTu 8988t C373(1.12)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C373(1.19)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C373(0.90)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C373(1.03)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C373(1.24)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C373(0.84)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C373(0.91)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C373(0.97)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C373(1.11)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C373(1.13)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C373(0.95)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C373(0.90)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C373(1.16)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C373(0.89)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C373(1.18)  LDD1243  [1]
 LDCM0367  CL1 PaTu 8988t C373(0.99)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C373(1.64)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C373(0.38)  LDD1248  [1]
 LDCM0374  CL105 PaTu 8988t C373(1.03)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C373(1.03)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C373(0.82)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C373(1.31)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C373(1.15)  LDD1257  [1]
 LDCM0379  CL11 PaTu 8988t C373(0.87)  LDD1258  [1]
 LDCM0380  CL110 PaTu 8988t C373(1.13)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C373(1.34)  LDD1260  [1]
 LDCM0382  CL112 PaTu 8988t C373(0.94)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C373(1.06)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C373(1.12)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C373(0.98)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C373(1.22)  LDD1265  [1]
 LDCM0387  CL117 PaTu 8988t C373(0.79)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C373(0.68)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C373(0.87)  LDD1268  [1]
 LDCM0390  CL12 PaTu 8988t C373(1.04)  LDD1269  [1]
 LDCM0391  CL120 PaTu 8988t C373(0.98)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C373(0.88)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C373(1.34)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C373(0.98)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C373(0.91)  LDD1274  [1]
 LDCM0396  CL125 PaTu 8988t C373(1.81)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C373(1.29)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C373(1.56)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C373(1.08)  LDD1278  [1]
 LDCM0400  CL13 PaTu 8988t C373(1.72)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C373(1.30)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C373(1.23)  LDD1281  [1]
 LDCM0407  CL2 PaTu 8988t C373(0.87)  LDD1286  [1]
 LDCM0418  CL3 PaTu 8988t C373(1.20)  LDD1297  [1]
 LDCM0429  CL4 PaTu 8988t C373(1.34)  LDD1308  [1]
 LDCM0436  CL46 PaTu 8988t C373(0.85)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C373(0.87)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C373(1.16)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C373(1.48)  LDD1318  [1]
 LDCM0440  CL5 PaTu 8988t C373(1.32)  LDD1319  [1]
 LDCM0441  CL50 PaTu 8988t C373(1.12)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C373(1.19)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C373(1.27)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C373(0.97)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C373(1.30)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C373(0.92)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C373(0.68)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C373(1.28)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C373(1.06)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C373(1.25)  LDD1329  [1]
 LDCM0451  CL6 PaTu 8988t C373(1.16)  LDD1330  [1]
 LDCM0452  CL60 PaTu 8988t C373(1.25)  LDD1331  [1]
 LDCM0462  CL7 PaTu 8988t C373(1.73)  LDD1341  [1]
 LDCM0469  CL76 PaTu 8988t C373(1.27)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C373(1.01)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C373(1.04)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C373(1.02)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C373(1.62)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C373(1.08)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C373(1.12)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C373(1.28)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C373(1.12)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C373(1.17)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C373(0.96)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C373(1.15)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C373(1.29)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C373(1.01)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C373(1.14)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C373(1.40)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C373(2.09)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C373(0.25)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C373(0.42)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C373(0.22)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C373(0.20)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C373(0.83)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C373(0.27)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C373(0.45)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C373(0.40)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C373(0.29)  LDD1373  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) CAMK Ser/Thr protein kinase family Q13557
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) Protein-tyrosine phosphatase family P26045
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ER membrane protein complex subunit 9 (EMC9) EMC8/EMC9 family Q9Y3B6
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tektin-4 (TEKT4) Tektin family Q8WW24
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

The Drug(s) Related To This Target

Approved
Click To Hide/Show 42 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ajmaline Small molecular drug DB01426
Benzonatate Small molecular drug D0Q2ES
Brivaracetam Small molecular drug DB05541
Carbamazepine Small molecular drug DB00564
Chloroprocaine Small molecular drug DB01161
Cinchocaine Small molecular drug DB00527
Cocaine Small molecular drug DB00907
Dibucaine Small molecular drug D0P5GE
Disopyramide Small molecular drug D0M4YC
Dronedarone Small molecular drug DB04855
Dyclonine Small molecular drug D04QLR
Ethotoin Small molecular drug D05EPM
Flecainide Small molecular drug DB01195
Fosphenytoin Small molecular drug D0J5YC
Hexylcaine Small molecular drug D08MRN
Indecainide Small molecular drug D0K4CQ
Isavuconazole Small molecular drug DB11633
Lamotrigine Small molecular drug DB00555
Lidocaine Small molecular drug DB00281
Lomerizine Small molecular drug D0N3ZJ
Mephenytoin Small molecular drug D07RGW
Mexiletine Small molecular drug D0X0RI
Moricizine Small molecular drug D04VPA
Phenytoin Small molecular drug DB00252
Prilocaine Small molecular drug D06LYG
Procainamide Small molecular drug DB01035
Promethazine Small molecular drug DB01069
Propafenone Small molecular drug DB01182
Quinidine Small molecular drug DB00908
Quinidine Barbiturate Small molecular drug DB01346
Ranolazine Small molecular drug DB00243
Riluzole Small molecular drug DB00740
Tetracaine Small molecular drug DB09085
Tetrodotoxin Small molecular drug D0C7ET
Tocainide Small molecular drug DB01056
Topiramate Small molecular drug DB00273
Valproic Acid Small molecular drug DB00313
Vernakalant Small molecular drug DB06217
Zonisamide Small molecular drug DB00909
Bioallethrin . DB13746
Fish Oil . DB13961
Pentoxyverine . DB11186
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
F-15845 Small molecular drug D00XWB
Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-[5-(4-chlorophenyl)-2-furoyl]Piperazine Small molecular drug D01AGR
Aconitine Small molecular drug D0A1MW
Aprindine Small molecular drug DB01429
Batrachotoxin Small molecular drug D0G9WE
Kc-12291 Small molecular drug D01SAX
N-(4-methyl-benzoyl)-n'-phenethyl-guanidine Small molecular drug D0O2RN
N-butyl-n'-(4-methyl-benzoyl)-guanidine Small molecular drug D06GQO
Veratridine Small molecular drug D0S4MN
Patented
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aryl Carboxamide Derivative 1 Small molecular drug D0M8WO
Aryl Carboxamide Derivative 2 Small molecular drug D0OP5F
Aryl Carboxamide Derivative 3 Small molecular drug D03WBS
Dihydrobenzoxazine And Tetrahydroquinoxaline Sulfonamide Derivative 1 Small molecular drug D0UL0K
Withdrawn from market
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Encainide Small molecular drug D06PAZ
Discontinued
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acecainide Small molecular drug D04BQR
Lubeluzole Small molecular drug D08LDS
Pd-85639 Small molecular drug D02NLI
Sipatrigine Small molecular drug D0EC2K

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.