Details of the Target

General Information of Target

Target ID LDTP05600
Target Name Non-homologous end joining factor IFFO1 (IFFO1)
Gene Name IFFO1
Gene ID 25900
Synonyms
IFFO; Non-homologous end joining factor IFFO1; NHEJ factor IFFO1; Intermediate filament family orphan 1; Tumor antigen HOM-TES-103
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAP
PAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLG
RRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTS
TSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA
LYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAE
LVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPS
MGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCD
SLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQI
ELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPP
PPSEAEDSDRDVSSDSSMR
Target Bioclass
Enzyme
Family
Intermediate filament family
Subcellular location
Nucleus
Function
Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation. Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites.
Uniprot ID
Q0D2I5
Ensemble ID
ENST00000336604.8
HGNC ID
HGNC:24970

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C341(0.85)  LDD1507  [1]
IPM
 Probe Info  		C341(0.00); C515(0.00)  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C341(0.85)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C341(0.99)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C341(0.91)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C341(1.20)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C341(1.33)  LDD1512  [1]
 LDCM0276  AC17 HEK-293T C341(0.85)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C341(1.00)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C341(1.12)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C341(1.07)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C341(1.09)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C341(1.13)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C341(0.95)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C341(0.87)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C341(1.12)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C341(1.14)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C341(0.97)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C341(1.09)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C341(0.97)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C341(1.18)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C341(1.05)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C341(1.02)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C341(0.98)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C341(0.95)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C341(1.08)  LDD1538  [1]
 LDCM0301  AC4 HEK-293T C341(0.98)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C341(1.08)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C341(1.07)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C341(1.27)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C341(1.00)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C341(0.81)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C341(1.20)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C341(1.16)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C341(0.95)  LDD1550  [1]
 LDCM0313  AC50 HEK-293T C341(0.94)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C341(1.01)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C341(1.02)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C341(1.15)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C341(1.00)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C341(1.05)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C341(0.97)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C341(0.99)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C341(1.07)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C341(1.09)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C341(1.07)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C341(1.08)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C341(1.17)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C341(0.92)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C341(1.10)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C341(1.35)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C341(1.12)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C341(1.05)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C341(1.24)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C341(0.98)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C341(1.04)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C341(0.99)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C341(0.86)  LDD1581  [1]
 LDCM0380  CL110 HEK-293T C341(0.98)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C341(1.16)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C341(1.01)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C341(1.03)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C341(1.20)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C341(1.28)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C341(0.94)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C341(1.10)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C341(1.06)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C341(0.75)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C341(0.81)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C341(0.81)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C341(0.93)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C341(1.26)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C341(1.38)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C341(0.80)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C341(0.78)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C341(0.92)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C341(0.79)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C341(0.97)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C341(0.99)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C341(1.08)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C341(0.85)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C341(0.99)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C341(1.24)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C341(1.12)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C341(0.84)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C341(0.80)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C341(1.00)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C341(0.90)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C341(0.99)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C341(0.89)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C341(1.13)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C341(0.92)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C341(1.27)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C341(0.99)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C341(1.04)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C341(0.77)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C341(0.89)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C341(0.78)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C341(1.11)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C341(1.07)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C341(1.21)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C341(1.09)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C341(0.93)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C341(0.94)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C341(0.87)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C341(0.84)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C341(1.06)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C341(1.09)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C341(1.06)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C341(0.99)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C341(1.40)  LDD1652  [1]
 LDCM0451  CL6 HEK-293T C341(1.12)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C341(0.98)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C341(0.98)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C341(0.98)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C341(0.99)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C341(0.93)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C341(0.94)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C341(0.98)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C341(1.06)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C341(1.03)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C341(1.42)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C341(1.27)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C341(0.83)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C341(0.88)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C341(1.18)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C341(0.97)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C341(0.87)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C341(1.09)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C341(0.97)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C341(1.22)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C341(1.15)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C341(0.76)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C341(0.94)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C341(0.89)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C341(1.15)  LDD1686  [1]
 LDCM0485  CL90 HEK-293T C341(1.07)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C341(0.94)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C341(0.92)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C341(1.11)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C341(1.18)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C341(0.82)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C341(1.03)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C341(1.02)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C341(0.95)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C341(0.84)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prelamin-A/C (LMNA) Intermediate filament family P02545
DNA repair protein XRCC4 (XRCC4) XRCC4-XLF family Q13426

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019