Details of the Target

General Information of Target

Target ID LDTP05397
Target Name Transforming growth factor beta receptor type 3 (TGFBR3)
Gene Name TGFBR3
Gene ID 7049
Synonyms
Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGL
PQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLA
TGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIA
RNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITP
NSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSI
GFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAE
EMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDG
LPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDV
TLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGY
EDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNT
DLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENIC
PKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKL
PKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFH
GLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGST
QSTPCSSSSTA
Target Bioclass
Cytokine and receptor
Subcellular location
Secreted
Function
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility.
Uniprot ID
Q03167
Ensemble ID
ENST00000212355.9
HGNC ID
HGNC:11774

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P194H .
DU145 SNV: p.S224C .
EOL1 SNV: p.R257S .
HCT116 SNV: p.P441S .
IGROV1 SNV: p.R375Q .
MEWO SNV: p.P647S .
MFE319 SNV: p.R165Ter .
NCIH196 SNV: p.S173L .
NCIH3122 SNV: p.G838S .
NCIH358 SNV: p.G539V .
SNU1 SNV: p.T116I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K672(0.83); K667(0.83); K314(1.52); K686(1.82)  LDD3494  [1]
DBIA
 Probe Info  		C660(2.94)  LDD3373  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C660(1.10)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C660(0.99)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C660(0.95)  LDD1510  [4]
 LDCM0270  AC15 HEK-293T C660(0.93)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C660(1.00)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C660(0.94)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C660(1.10)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C660(1.00)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C660(0.97)  LDD1520  [4]
 LDCM0283  AC23 HEK-293T C660(0.92)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C660(0.97)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C660(1.07)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C660(0.94)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C660(0.95)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C660(0.94)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C660(0.94)  LDD1529  [4]
 LDCM0292  AC31 HEK-293T C660(0.92)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C660(1.00)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C660(1.12)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C660(1.11)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C660(0.94)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C660(0.97)  LDD1537  [4]
 LDCM0300  AC39 HEK-293T C660(0.94)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C660(1.05)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C660(1.05)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C660(1.06)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C660(1.06)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C660(0.93)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C660(1.10)  LDD1546  [4]
 LDCM0309  AC47 HEK-293T C660(0.97)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C660(1.08)  LDD1549  [4]
 LDCM0312  AC5 HEK-293T C660(1.01)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C660(1.08)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C660(1.07)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C660(1.03)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C660(0.90)  LDD1555  [4]
 LDCM0318  AC55 HEK-293T C660(0.86)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C660(1.01)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C660(1.08)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C660(1.10)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C660(1.04)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C660(0.97)  LDD1564  [4]
 LDCM0327  AC63 HEK-293T C660(0.92)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C660(1.04)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C660(0.99)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C660(1.02)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C660(0.96)  LDD1511  [4]
 LDCM0275  AKOS034007705 HEK-293T C660(0.98)  LDD1514  [4]
 LDCM0369  CL100 HEK-293T C660(1.14)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C660(1.04)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C660(1.18)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C660(1.06)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C660(0.99)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C660(1.03)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C660(1.06)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C660(0.96)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C660(1.13)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C660(1.06)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C660(1.08)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C660(1.06)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C660(1.17)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C660(0.99)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C660(1.02)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C660(1.00)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C660(1.12)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C660(1.06)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C660(1.00)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C660(1.01)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C660(1.09)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C660(0.99)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C660(1.07)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C660(0.93)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C660(1.04)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C660(1.19)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C660(0.98)  LDD1607  [4]
 LDCM0405  CL18 HEK-293T C660(1.05)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C660(0.96)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C660(1.04)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C660(0.96)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C660(1.08)  LDD1613  [4]
 LDCM0411  CL23 HEK-293T C660(0.90)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C660(1.04)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C660(0.98)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C660(1.15)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C660(1.03)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C660(1.13)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C660(1.11)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C660(0.96)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C660(1.12)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C660(1.22)  LDD1626  [4]
 LDCM0424  CL35 HEK-293T C660(1.12)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C660(0.99)  LDD1629  [4]
 LDCM0428  CL39 HEK-293T C660(1.20)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C660(1.14)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C660(1.00)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C660(0.82)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C660(0.89)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C660(0.97)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C660(1.13)  LDD1639  [4]
 LDCM0437  CL47 HEK-293T C660(1.03)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C660(0.99)  LDD1642  [4]
 LDCM0441  CL50 HEK-293T C660(1.06)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C660(0.99)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C660(1.01)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C660(1.03)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C660(1.00)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C660(1.12)  LDD1651  [4]
 LDCM0450  CL59 HEK-293T C660(0.95)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C660(0.95)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C660(1.23)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C660(1.04)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C660(1.05)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C660(1.22)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C660(1.05)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C660(0.97)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C660(1.08)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C660(0.98)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C660(0.91)  LDD1665  [4]
 LDCM0464  CL71 HEK-293T C660(0.98)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C660(1.02)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C660(0.98)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C660(0.98)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C660(1.02)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C660(0.97)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C660(2.23)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C660(1.00)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C660(0.97)  LDD1678  [4]
 LDCM0477  CL83 HEK-293T C660(0.93)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C660(0.94)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C660(0.96)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C660(0.93)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C660(0.97)  LDD1685  [4]
 LDCM0484  CL9 HEK-293T C660(0.92)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C660(1.29)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C660(0.81)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C660(1.24)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C660(1.06)  LDD1691  [4]
 LDCM0490  CL95 HEK-293T C660(1.18)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C660(0.95)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C660(1.00)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C660(1.38)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C660(1.09)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C660(0.98)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C660(0.98)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C660(0.74)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C660(0.90)  LDD1497  [4]
 LDCM0024  KB05 OCUG-1 C660(2.94)  LDD3373  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transforming growth factor beta-1 proprotein (TGFB1) TGF-beta family P01137
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PDZ domain-containing protein GIPC1 (GIPC1) GIPC family O14908

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402