Details of the Target

General Information of Target

Target ID LDTP05352
Target Name Amyloid-beta A4 precursor protein-binding family A member 1 (APBA1)
Gene Name APBA1
Gene ID 320
Synonyms
MINT1; X11; Amyloid-beta A4 precursor protein-binding family A member 1; Adapter protein X11alpha; Neuron-specific X11 protein; Neuronal Munc18-1-interacting protein 1; Mint-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDL
RAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAV
QYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGED
EPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDE
RSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDL
ERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEV
KTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLH
PSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN
VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDH
PLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLI
AQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE
KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS
TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERG
GVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm; Golgi apparatus
Function
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.
Uniprot ID
Q02410
Ensemble ID
ENST00000265381.7
HGNC ID
HGNC:578

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.E206K .
CHL1 SNV: p.L828V .
G415 SNV: p.E15Q .
HCT116 SNV: p.Y338C .
HCT15 SNV: p.P186S .
HUH7 SNV: p.R227L .
Ishikawa (Heraklio) 02 ER SNV: p.G335W .
LS123 SNV: p.L828V .
LS180 Deletion: p.N480TfsTer4 .
MELJUSO SNV: p.E159K; p.L828V .
MEWO SNV: p.E26K; p.E570K .
MOLT4 SNV: p.G605E; p.A811V .
NCIH2172 SNV: p.A140P .
RL952 SNV: p.R260C .
SUPT1 SNV: p.A290V .
SW1783 SNV: p.D287N .
SW837 SNV: p.E5Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C742(1.84)  LDD3344  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C654(0.99)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C654(0.95)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C654(1.08)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C654(1.05); C769(1.00)  LDD1512  [2]
 LDCM0277  AC18 HEK-293T C654(1.16)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C654(0.88)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C654(0.97)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C654(1.05)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C769(1.54)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C654(1.14); C769(1.14)  LDD1521  [2]
 LDCM0284  AC24 HEK-293T C769(1.04)  LDD1523  [2]
 LDCM0286  AC26 HEK-293T C654(1.04)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C654(0.84)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C654(1.02)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C769(1.29)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C654(1.09)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C654(1.03); C769(1.40)  LDD1530  [2]
 LDCM0293  AC32 HEK-293T C769(0.87)  LDD1532  [2]
 LDCM0295  AC34 HEK-293T C654(0.99)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C654(0.97)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C654(0.96)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C769(1.48)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C654(1.04); C769(1.12)  LDD1538  [2]
 LDCM0301  AC4 HEK-293T C654(1.01)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C769(1.02)  LDD1541  [2]
 LDCM0304  AC42 HEK-293T C654(1.04)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C654(0.93)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C654(1.02)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C769(1.23)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C654(1.18); C769(1.15)  LDD1547  [2]
 LDCM0310  AC48 HEK-293T C769(0.85)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C769(1.24)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C654(0.97)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C654(0.98)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C654(0.92)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C769(0.98)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C654(1.16); C769(1.12)  LDD1556  [2]
 LDCM0319  AC56 HEK-293T C769(0.96)  LDD1558  [2]
 LDCM0321  AC58 HEK-293T C654(1.00)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C654(0.94)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C654(1.08); C769(1.19)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C654(0.99)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C769(1.96)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C654(1.07); C769(0.98)  LDD1565  [2]
 LDCM0328  AC64 HEK-293T C769(1.16)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C769(0.95)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C769(1.54)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C769(1.06)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C654(1.11)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C654(1.14); C769(0.87)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C654(0.90)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C654(0.92)  LDD1574  [2]
 LDCM0373  CL104 HEK-293T C654(0.84)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C654(0.96)  LDD1578  [2]
 LDCM0377  CL108 HEK-293T C654(0.94)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C654(0.98)  LDD1582  [2]
 LDCM0382  CL112 HEK-293T C654(0.82)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C654(1.10)  LDD1587  [2]
 LDCM0386  CL116 HEK-293T C654(0.91)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C654(1.01)  LDD1591  [2]
 LDCM0390  CL12 HEK-293T C769(0.95)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C654(0.96)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C654(1.03)  LDD1596  [2]
 LDCM0395  CL124 HEK-293T C654(0.95)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C654(1.16)  LDD1600  [2]
 LDCM0399  CL128 HEK-293T C654(0.92)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C654(1.00)  LDD1604  [2]
 LDCM0403  CL16 HEK-293T C654(0.90)  LDD1607  [2]
 LDCM0405  CL18 HEK-293T C654(1.08)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C654(1.18)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C654(1.04)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C769(1.01)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C654(1.25); C769(0.90)  LDD1614  [2]
 LDCM0412  CL24 HEK-293T C769(0.78)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C654(1.18)  LDD1617  [2]
 LDCM0416  CL28 HEK-293T C654(0.95)  LDD1620  [2]
 LDCM0419  CL30 HEK-293T C654(1.05)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C654(0.89)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C654(1.02)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C769(1.93)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C654(1.01); C769(1.01)  LDD1627  [2]
 LDCM0425  CL36 HEK-293T C769(0.69)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C654(1.01)  LDD1630  [2]
 LDCM0429  CL4 HEK-293T C654(0.95)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C654(0.96)  LDD1634  [2]
 LDCM0432  CL42 HEK-293T C654(1.13)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C654(1.04)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C654(0.97)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C769(1.06)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C654(0.99); C769(1.03)  LDD1640  [2]
 LDCM0438  CL48 HEK-293T C769(0.77)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C654(1.04)  LDD1643  [2]
 LDCM0443  CL52 HEK-293T C654(0.92)  LDD1646  [2]
 LDCM0445  CL54 HEK-293T C654(0.91)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C654(0.99)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C654(1.06)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C769(1.16)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C654(1.23); C769(0.89)  LDD1652  [2]
 LDCM0451  CL6 HEK-293T C654(0.91)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C769(0.83)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C654(1.22)  LDD1656  [2]
 LDCM0456  CL64 HEK-293T C654(0.92)  LDD1659  [2]
 LDCM0458  CL66 HEK-293T C654(1.07)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C654(1.01)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C654(1.01)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C769(1.35)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C654(1.11)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C654(1.10); C769(1.03)  LDD1666  [2]
 LDCM0465  CL72 HEK-293T C769(0.88)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C654(1.02)  LDD1669  [2]
 LDCM0469  CL76 HEK-293T C654(1.06)  LDD1672  [2]
 LDCM0471  CL78 HEK-293T C654(1.09)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C654(1.01)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C654(0.85)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C654(0.90)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C769(1.32)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C654(1.19); C769(1.08)  LDD1679  [2]
 LDCM0478  CL84 HEK-293T C769(0.90)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C654(1.41)  LDD1682  [2]
 LDCM0482  CL88 HEK-293T C654(1.06)  LDD1685  [2]
 LDCM0484  CL9 HEK-293T C769(1.03)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C654(0.96)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C654(1.08)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C654(0.98)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C769(1.36)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C654(1.14); C769(1.02)  LDD1692  [2]
 LDCM0491  CL96 HEK-293T C769(1.03)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C654(1.12)  LDD1695  [2]
 LDCM0022  KB02 A101D C74(1.45); C742(1.46)  LDD2250  [1]
 LDCM0023  KB03 769-P C74(1.44)  LDD2663  [1]
 LDCM0024  KB05 NCI-H146 C742(1.84)  LDD3344  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402