Details of the Target

General Information of Target

Target ID LDTP05338
Target Name Guanylate cyclase soluble subunit beta-1 (GUCY1B1)
Gene Name GUCY1B1
Gene ID 2983
Synonyms
GUC1B3; GUCSB3; GUCY1B3; Guanylate cyclase soluble subunit beta-1; GCS-beta-1; EC 4.6.1.2; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Adenylyl cyclase class-4/guanylyl cyclase family
Subcellular location
Cytoplasm
Function Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
TTD ID
T61581
Uniprot ID
Q02153
DrugMap ID
TTLBYH1
Ensemble ID
ENST00000264424.13
HGNC ID
HGNC:4687
ChEMBL ID
CHEMBL3137281

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.R197G; p.E368Ter .
HT SNV: p.I422T .
HT115 SNV: p.D374G .
IGR37 SNV: p.S495P .
IGR39 SNV: p.S495P .
MOLT4 SNV: p.G159D .
NCIH2286 SNV: p.E28G .
YSCCC SNV: p.E173Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C214(2.25)  LDD3364  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C174(1.05)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C214(1.02); C174(1.00)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C174(0.86)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C174(1.17)  LDD1510  [4]
 LDCM0270  AC15 HEK-293T C174(1.04)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C174(0.93)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C214(0.90); C174(0.92)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C174(1.13)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C214(1.17); C174(0.87)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C174(1.07)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C232(0.68); C174(1.18)  LDD1520  [4]
 LDCM0283  AC23 HEK-293T C174(0.96)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C232(0.86); C174(0.94)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C174(0.88)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C214(1.01); C174(0.95)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C174(1.00)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C174(1.07)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C232(0.69); C174(1.11)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C174(0.99)  LDD1529  [4]
 LDCM0292  AC31 HEK-293T C174(1.14)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C232(0.84); C174(0.89)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C174(1.10)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C214(1.17); C174(1.03)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C174(1.05)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C174(1.12)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C232(0.62); C174(1.02)  LDD1537  [4]
 LDCM0300  AC39 HEK-293T C174(1.08)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C174(0.99)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C232(0.93); C174(1.02)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C174(1.01)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C214(1.11); C174(1.00)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C174(0.98)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C174(1.06)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C232(1.23); C174(1.13)  LDD1546  [4]
 LDCM0309  AC47 HEK-293T C174(1.22)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C232(0.92); C174(1.20)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C174(1.09)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C232(0.87); C174(1.03)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C214(1.02); C174(1.34)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C174(0.93)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C174(1.05)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C232(0.78); C174(1.12)  LDD1555  [4]
 LDCM0318  AC55 HEK-293T C174(1.10)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C232(0.93); C174(1.22)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C174(0.95)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C214(1.12); C174(0.88)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C174(1.11)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C174(1.02)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C232(0.94); C174(1.03)  LDD1564  [4]
 LDCM0327  AC63 HEK-293T C174(1.01)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C232(0.81); C174(1.06)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C174(1.11)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C232(0.78); C174(0.96)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C232(0.93); C174(1.17)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C174(1.06)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C232(0.78); C174(1.11)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C214(1.00); C174(0.80)  LDD1571  [4]
 LDCM0369  CL100 HEK-293T C174(1.18)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C214(0.97); C174(0.98)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C214(1.15); C174(1.07)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C174(0.82)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C174(1.31)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C214(1.01); C174(0.85)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C214(1.01); C174(1.00)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C174(0.96)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C174(1.22)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C214(1.11); C174(0.96)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C174(1.02)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C214(0.98); C174(1.01)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C174(0.81)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C174(1.31)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C214(1.06); C174(0.93)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C214(1.21); C174(0.88)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C174(0.87)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C174(1.00)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C214(1.00); C174(0.93)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C214(1.03); C174(1.35)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C174(0.94)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C232(0.77); C174(1.04)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C174(1.00)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C214(1.10); C174(1.04)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C214(0.99); C174(1.40)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C174(0.84)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C174(1.46)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C214(1.12); C174(0.91)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C214(1.10); C174(0.96)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C174(0.77)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C174(1.23)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C214(0.95); C174(1.00)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C214(0.86); C174(1.06)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C174(0.62)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C174(0.87)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C174(0.86)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C214(0.96); C174(1.02)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C174(0.99)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C214(0.93); C174(1.11)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C174(1.21)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C232(0.58); C174(1.09)  LDD1613  [4]
 LDCM0411  CL23 HEK-293T C174(1.07)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C232(0.80); C174(1.07)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C214(1.15); C174(0.96)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C214(0.96); C174(1.01)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C174(1.01)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C174(0.99)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C174(0.96)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C174(0.70)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C214(0.90); C174(1.15)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C174(1.07)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C174(1.24)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C232(0.61); C174(1.59)  LDD1626  [4]
 LDCM0424  CL35 HEK-293T C174(1.14)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C232(0.81); C174(1.26)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C214(1.03); C174(0.86)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C174(0.74)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C174(0.92)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C174(1.42)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C174(0.84)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C214(0.93); C174(0.91)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C174(1.03)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C174(0.97)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C232(0.62); C174(1.29)  LDD1639  [4]
 LDCM0437  CL47 HEK-293T C174(1.04)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C232(0.67); C174(1.13)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C214(1.08); C174(0.82)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C174(0.86)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C214(1.12); C174(0.95)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C174(1.03)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C174(0.85)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C214(1.19); C174(1.06)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C174(0.96)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C174(1.11)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C232(0.59); C174(1.08)  LDD1651  [4]
 LDCM0450  CL59 HEK-293T C174(1.24)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C214(0.95); C174(0.99)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C232(0.71); C174(1.18)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C214(0.99); C174(0.92)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C214(1.00); C174(1.12)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C174(0.81)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C174(0.79)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C174(1.01)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C214(0.98); C174(0.96)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C174(0.96)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C174(1.05)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C232(0.51); C174(1.10)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C174(0.93)  LDD1665  [4]
 LDCM0464  CL71 HEK-293T C174(1.05)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C232(0.78); C174(1.04)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C214(1.06); C174(0.87)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C214(0.97); C174(1.03)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C174(0.95)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C174(0.93)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C214(1.00); C174(1.04)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C174(1.08)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C174(0.79)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C174(1.04)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C232(0.44); C174(1.21)  LDD1678  [4]
 LDCM0477  CL83 HEK-293T C174(1.16)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C232(0.87); C174(0.99)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C214(1.15); C174(0.92)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C214(1.19); C174(0.94)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C174(0.65)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C174(1.10)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C174(0.89)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C232(0.56); C174(1.15)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C214(1.19); C174(1.31)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C174(1.33)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C174(0.99)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C232(0.78); C174(1.12)  LDD1691  [4]
 LDCM0490  CL95 HEK-293T C174(0.93)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C232(0.67); C174(1.01)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C214(1.28); C174(0.78)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C214(1.08); C174(1.11)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C174(0.72)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C174(0.94)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C174(1.06)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C214(0.96); C174(1.09)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C174(1.00)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C174(0.89)  LDD1497  [4]
 LDCM0024  KB05 NCI-N87 C214(2.25)  LDD3364  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1) Adenylyl cyclase class-4/guanylyl cyclase family Q02108

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vericiguat Small molecular drug DB15456
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cinaciguat Small molecular drug D0ZT0G
Vericigiuat . D08YVP
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rig-200 Small molecular drug D00TLD

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402