Details of the Target

General Information of Target

Target ID LDTP05216
Target Name Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2)
Gene Name HSPG2
Gene ID 3339
Synonyms
Basement membrane-specific heparan sulfate proteoglycan core protein; HSPG; Perlecan; PLC) [Cleaved into: Endorepellin; LG3 peptide]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDML
ADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLE
SEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTS
PQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLG
ISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPR
DYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCP
TKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR
GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE
AMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQI
RLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPE
QFLGNKVDSYGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQR
QVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHAT
SHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHC
LNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCD
ACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVG
RLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAAS
THTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPG
STPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMA
LAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDC
DTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQR
GTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQG
QPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPD
GCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGA
QLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGN
NIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSV
PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHC
ELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNP
ENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVE
VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSD
AGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP
AYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS
GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRL
PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAA
GVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQV
VVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS
RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSS
SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHV
VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK
RGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGST
QPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPA
DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLV
AGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI
QQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI
VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT
VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANN
NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTW
HKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHV
PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRL
NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ
TLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE
QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN
QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG
PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDA
GTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPA
PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY
ATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDS
GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH
CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQ
LVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVV
RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASG
YPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE
RVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ
PDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVN
GTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAH
GISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCV
NRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPL
APDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAER
LNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEV
SVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLC
EHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPG
QYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFI
SLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSP
GPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRA
QAGANTRPCPS
Target Type
Discontinued
Target Bioclass
Immunoglobulin
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity.
TTD ID
T73075
Uniprot ID
P98160
DrugMap ID
TT5UM29
Ensemble ID
ENST00000374695.8
HGNC ID
HGNC:5273

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K3155(1.37); K1414(1.42); K4023(5.16)  LDD3494  [1]
DBIA
 Probe Info  		C344(0.93); C350(0.93); C359(0.93)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C292(0.00); C285(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C892(0.00); C4389(0.00); C4355(0.00); C731(0.00)  LDD0162  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
Acrolein
 Probe Info  		C731(0.00); C2407(0.00)  LDD0217  [6]
Crotonaldehyde
 Probe Info  		C3134(0.00); H2528(0.00); H2385(0.00)  LDD0219  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C4389(1.23)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C4389(1.14)  LDD0824  [2]
 LDCM0230  AC113 HEK-293T C4389(1.05)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C4389(1.16)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C4389(1.07)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C4389(1.23)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C4389(1.10)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C4389(1.12)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C4389(1.12)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C4389(1.13)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C4389(1.27)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C4389(1.11)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C4389(0.90)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C4389(0.92)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C4389(1.07)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C4389(0.93)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C4389(0.88)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C4389(0.94)  LDD0843  [2]
 LDCM0259  AC14 HEK-293T C4389(1.05)  LDD0857  [2]
 LDCM0263  AC143 HEK-293T C4389(0.81)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C4389(0.85)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C4389(0.86)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C4389(0.89)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C4389(0.78)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C4389(0.90)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C4389(1.00)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C4389(1.14)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C4389(0.94)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C4389(1.00)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C4389(1.08)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C4389(0.95)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C4389(0.91)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C4389(0.94)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C4389(0.85)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C4389(0.79)  LDD2165  [2]
 LDCM0285  AC25 HEK-293T C4389(1.30)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C4389(1.11)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C4389(0.89)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C4389(1.75)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C4389(1.29)  LDD0887  [2]
 LDCM0291  AC30 HEK-293T C4389(1.13)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C4389(1.24)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C4389(1.23)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C4389(1.11)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C4389(1.28)  LDD0893  [2]
 LDCM0323  AC6 HEK-293T C4389(1.18)  LDD0921  [2]
 LDCM0332  AC68 HEK-293T C4389(1.03)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C4389(1.12)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C4389(1.18)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C4389(1.20)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C4389(1.31)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C4389(0.99)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C4389(1.10)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C4389(1.31)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C4389(1.18)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C4389(1.28)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C4389(1.35)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C4389(1.11)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C4389(1.21)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C4389(1.25)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C4389(1.14)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C4389(1.33)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C4389(1.16)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C4389(0.75)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C4389(0.97)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C4389(0.86)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C4389(0.92)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C4389(0.91)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C4389(0.96)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C4389(0.94)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C4389(1.01)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C4389(1.00)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C4389(0.97)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C4389(0.83)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C4389(1.02)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C4389(0.98)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C4389(0.93)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C4389(0.86)  LDD0962  [2]
 LDCM0248  AKOS034007472 HEK-293T C4389(1.19)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C4389(1.23)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C4389(1.17)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C344(0.93); C350(0.93); C359(0.93)  LDD0078  [2]
 LDCM0108  Chloroacetamide HeLa C479(0.00); C3134(0.00); C4389(0.00); C2696(0.00)  LDD0222  [6]
 LDCM0370  CL101 HEK-293T C4389(1.25)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C4389(1.10)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C4389(1.25)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C4389(1.21)  LDD0971  [2]
 LDCM0382  CL112 HEK-293T C4389(1.18)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C4389(1.52)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C4389(1.37)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C4389(1.17)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C4389(1.15)  LDD0984  [2]
 LDCM0420  CL31 HEK-293T C4389(1.15)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C4389(1.08)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C4389(1.03)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C4389(0.98)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C4389(1.07)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C4389(1.01)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C4389(1.06)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C4389(0.90)  LDD1026  [2]
 LDCM0430  CL40 HEK-293T C4389(1.05)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C4389(1.01)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C4389(0.99)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C4389(0.95)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C4389(1.06)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C4389(0.97)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C4389(1.19)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C4389(1.04)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C4389(1.19)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C4389(1.11)  LDD1037  [2]
 LDCM0441  CL50 HEK-293T C4389(1.00)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C4389(0.91)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C4389(1.08)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C4389(0.93)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C4389(1.05)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C4389(1.13)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C4389(1.06)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C4389(1.03)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C4389(0.98)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C4389(1.09)  LDD1048  [2]
 LDCM0452  CL60 HEK-293T C4389(1.14)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C4389(1.11)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C4389(1.12)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C4389(1.33)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C4389(0.99)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C4389(1.16)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C4389(1.15)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C4389(1.12)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C4389(1.07)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C4389(1.09)  LDD1059  [2]
 LDCM0463  CL70 HEK-293T C4389(1.06)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C4389(1.17)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C4389(1.35)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C4389(1.08)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C4389(1.15)  LDD1065  [2]
 LDCM0468  Fragment33 HEK-293T C4389(1.17)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C4389(0.98)  LDD1025  [2]
 LDCM0022  KB02 42-MG-BA C892(1.90); C368(1.53)  LDD2244  [7]
 LDCM0023  KB03 769-P C3819(3.23); C892(1.88); C368(1.53)  LDD2663  [7]
 LDCM0024  KB05 G361 C3819(2.60); C731(1.01); C1530(1.30); C4389(1.48)  LDD3311  [7]
 LDCM0109  NEM HeLa H3544(0.00); H2385(0.00)  LDD0223  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vascular endothelial growth factor receptor 2 (KDR) Tyr protein kinase family P35968

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Palifermin BiotechDrug DB00039
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rus 3108 . D0ZD6Y

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840