Details of the Target

General Information of Target

Target ID LDTP04978
Target Name Small nuclear ribonucleoprotein G (SNRPG)
Gene Name SNRPG
Gene ID 6637
Synonyms
PBSCG; Small nuclear ribonucleoprotein G; snRNP-G; Sm protein G; Sm-G; SmG
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMV
VIRGNSIIMLEALERV
Target Bioclass
Other
Family
SnRNP Sm proteins family
Subcellular location
Cytoplasm, cytosol
Function
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome . Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
Uniprot ID
P62308
Ensemble ID
ENST00000272348.7
HGNC ID
HGNC:11163

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K10(8.47); K20(7.43)  LDD0277  [1]
DBIA
 Probe Info  		C45(1.04)  LDD3349  [2]
ATP probe
 Probe Info  		K3(0.00); K10(0.00); K11(0.00)  LDD0199  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [7]
SF
 Probe Info  		K10(0.00); K3(0.00)  LDD0028  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C45(1.09)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C45(0.99)  LDD1509  [10]
 LDCM0259  AC14 HEK-293T C45(1.01)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C45(0.96)  LDD1513  [10]
 LDCM0277  AC18 HEK-293T C45(1.01)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C45(0.70)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C45(0.97)  LDD1518  [10]
 LDCM0281  AC21 HEK-293T C45(1.07)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C45(1.03)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C45(0.78)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C45(1.40)  LDD1523  [10]
 LDCM0286  AC26 HEK-293T C45(1.12)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C45(1.00)  LDD1526  [10]
 LDCM0289  AC29 HEK-293T C45(0.85)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C45(0.96)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C45(1.00)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C45(1.01)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C45(1.22)  LDD1532  [10]
 LDCM0295  AC34 HEK-293T C45(1.03)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C45(1.15)  LDD1535  [10]
 LDCM0298  AC37 HEK-293T C45(1.00)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C45(0.92)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C45(0.92)  LDD1539  [10]
 LDCM0302  AC40 HEK-293T C45(1.08)  LDD1541  [10]
 LDCM0304  AC42 HEK-293T C45(1.15)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C45(1.00)  LDD1544  [10]
 LDCM0307  AC45 HEK-293T C45(0.93)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C45(1.05)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C45(1.05)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C45(1.07)  LDD1549  [10]
 LDCM0312  AC5 HEK-293T C45(0.96)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C45(0.98)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C45(1.03)  LDD1553  [10]
 LDCM0316  AC53 HEK-293T C45(1.13)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C45(1.03)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C45(1.11)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C45(1.40)  LDD1558  [10]
 LDCM0321  AC58 HEK-293T C45(1.35)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C45(0.90)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C45(0.94)  LDD1562  [10]
 LDCM0325  AC61 HEK-293T C45(1.01)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C45(0.97)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C45(0.80)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C45(1.28)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C45(0.88)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C45(1.12)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C45(1.10)  LDD1511  [10]
 LDCM0275  AKOS034007705 HEK-293T C45(1.29)  LDD1514  [10]
 LDCM0367  CL1 HEK-293T C45(1.03)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C45(0.79)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C45(1.01)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C45(1.06)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C45(0.96)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C45(0.94)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C45(0.88)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C45(1.00)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C45(0.82)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C45(1.19)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C45(1.02)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C45(1.23)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C45(1.10)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C45(0.89)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C45(0.94)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C45(1.04)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C45(1.14)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C45(0.84)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C45(1.04)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C45(1.09)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C45(1.13)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C45(1.03)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C45(1.00)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C45(1.25)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C45(1.21)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C45(0.77)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C45(0.94)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C45(0.99)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C45(1.00)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C45(1.21)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C45(1.06)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C45(0.91)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C45(0.90)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C45(0.91)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C45(1.12)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C45(0.80)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C45(0.91)  LDD1607  [10]
 LDCM0405  CL18 HEK-293T C45(1.01)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C45(0.95)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C45(1.12)  LDD1611  [10]
 LDCM0409  CL21 HEK-293T C45(0.84)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C45(0.92)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C45(1.37)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C45(0.92)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C45(0.91)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C45(0.95)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C45(0.93)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C45(1.04)  LDD1620  [10]
 LDCM0418  CL3 HEK-293T C45(0.96)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C45(1.00)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C45(0.82)  LDD1624  [10]
 LDCM0422  CL33 HEK-293T C45(0.86)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C45(0.96)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C45(0.81)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C45(0.96)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C45(1.02)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C45(0.86)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C45(0.93)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C45(0.95)  LDD1634  [10]
 LDCM0432  CL42 HEK-293T C45(1.02)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C45(0.86)  LDD1637  [10]
 LDCM0435  CL45 HEK-293T C45(0.96)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C45(1.19)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C45(0.96)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C45(1.14)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C45(0.99)  LDD1643  [10]
 LDCM0441  CL50 HEK-293T C45(0.99)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C45(1.06)  LDD1646  [10]
 LDCM0445  CL54 HEK-293T C45(0.67)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C45(0.99)  LDD1649  [10]
 LDCM0448  CL57 HEK-293T C45(0.90)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C45(0.93)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C45(1.45)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C45(1.27)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C45(1.13)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C45(1.19)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C45(1.17)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C45(0.90)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C45(0.98)  LDD1659  [10]
 LDCM0458  CL66 HEK-293T C45(0.95)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C45(0.88)  LDD1662  [10]
 LDCM0461  CL69 HEK-293T C45(0.83)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C45(0.94)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C45(1.05)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C45(0.97)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C45(1.26)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C45(1.14)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C45(1.10)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C45(0.96)  LDD1672  [10]
 LDCM0471  CL78 HEK-293T C45(1.12)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C45(1.02)  LDD1675  [10]
 LDCM0475  CL81 HEK-293T C45(1.04)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C45(0.99)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C45(0.94)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C45(1.24)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C45(0.77)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C45(0.89)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C45(0.95)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C45(0.95)  LDD1685  [10]
 LDCM0484  CL9 HEK-293T C45(0.87)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C45(1.01)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C45(0.81)  LDD1689  [10]
 LDCM0488  CL93 HEK-293T C45(0.91)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C45(0.93)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C45(0.93)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C45(1.22)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C45(0.87)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C45(0.97)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C45(0.90)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C45(1.12)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C45(0.93)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C45(0.84)  LDD1631  [10]
 LDCM0022  KB02 Calu-1 C45(0.93)  LDD2292  [2]
 LDCM0023  KB03 COR-L88 C45(0.90)  LDD2728  [2]
 LDCM0024  KB05 NCI-H1793 C45(1.04)  LDD3349  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methylosome subunit pICln (CLNS1A) PICln (TC 1.A.47) family P54105
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Small nuclear ribonucleoprotein E (SNRPE) SnRNP Sm proteins family P62304
T-cell leukemia/lymphoma protein 1B (TCL1B) TCL1 family O95988
Four and a half LIM domains protein 3 (FHL3) . Q13643
Trefoil factor 2 (TFF2) . Q03403

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402