Details of the Target

General Information of Target

Target ID LDTP04937
Target Name Beta-2-microglobulin (B2M)
Gene Name B2M
Gene ID 567
Synonyms
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
Target Type
Literature-reported
Target Bioclass
Immunoglobulin
Family
Beta-2-microglobulin family
Subcellular location
Secreted
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.
TTD ID
T58080
Uniprot ID
P61769
DrugMap ID
TTY7FKA
Ensemble ID
ENST00000559916.1
HGNC ID
HGNC:914

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K111(5.81); K114(6.46)  LDD0274  [1]
STPyne
 Probe Info  		K111(6.66); K114(10.00); K26(7.41)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K26(10.12); K114(15.62); K111(15.62)  LDD3494  [2]
BTD
 Probe Info  		C100(1.23)  LDD2125  [3]
DBIA
 Probe Info  		C45(1.07)  LDD1492  [4]
5E-2FA
 Probe Info  		H71(0.00); H33(0.00); H51(0.00)  LDD2235  [5]
m-APA
 Probe Info  		H33(0.00); H51(0.00); H71(0.00)  LDD2231  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
Acrolein
 Probe Info  		H71(0.00); H104(0.00); H51(0.00)  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		C45(0.00); C100(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C45(1.06)  LDD1508  [4]
 LDCM0259  AC14 HEK-293T C45(1.18)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C45(0.98)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C45(0.96)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C45(1.02)  LDD1518  [4]
 LDCM0281  AC21 HEK-293T C45(1.08)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C45(1.19)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C45(0.95)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C100(0.89)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C45(1.01)  LDD1525  [4]
 LDCM0289  AC29 HEK-293T C45(1.05)  LDD1528  [4]
 LDCM0291  AC30 HEK-293T C45(0.93)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C45(1.04)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C100(1.52)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C45(1.01)  LDD1534  [4]
 LDCM0298  AC37 HEK-293T C45(1.07)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C45(1.06)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C45(1.08)  LDD1539  [4]
 LDCM0302  AC40 HEK-293T C100(1.49)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C45(1.01)  LDD1543  [4]
 LDCM0307  AC45 HEK-293T C45(1.33)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C45(1.04)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C45(1.01)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C100(0.77)  LDD1549  [4]
 LDCM0312  AC5 HEK-293T C45(1.30)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C45(1.00)  LDD1552  [4]
 LDCM0316  AC53 HEK-293T C45(0.93)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C45(0.95)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C45(0.93)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C100(0.82)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C45(0.99)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C45(1.04)  LDD1562  [4]
 LDCM0325  AC61 HEK-293T C45(0.82)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C45(0.95)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C45(1.09)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C100(1.09)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C45(1.14)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C100(1.00)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C45(0.94)  LDD1511  [4]
 LDCM0275  AKOS034007705 HEK-293T C100(0.96)  LDD1514  [4]
 LDCM0108  Chloroacetamide HeLa C45(0.00); H71(0.00); H51(0.00); H104(0.00)  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C45(1.00)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C45(1.22)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C45(0.91); C100(1.62)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C45(1.00)  LDD1574  [4]
 LDCM0372  CL103 HEK-293T C45(1.08)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C45(0.81); C100(1.38)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C45(1.19)  LDD1578  [4]
 LDCM0376  CL107 HEK-293T C45(1.08)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C45(0.88); C100(1.20)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C45(1.14)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C45(0.99)  LDD1583  [4]
 LDCM0381  CL111 HEK-293T C45(1.14)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C45(1.05); C100(1.12)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C45(1.00)  LDD1587  [4]
 LDCM0385  CL115 HEK-293T C45(1.08)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C45(1.03); C100(0.85)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C45(1.05)  LDD1591  [4]
 LDCM0389  CL119 HEK-293T C45(1.06)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C100(0.81)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C45(0.99); C100(1.47)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C45(1.05)  LDD1596  [4]
 LDCM0394  CL123 HEK-293T C45(0.83)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C45(0.93); C100(0.99)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C45(0.59)  LDD1600  [4]
 LDCM0398  CL127 HEK-293T C45(0.81)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C45(0.82); C100(1.07)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C45(0.84)  LDD1604  [4]
 LDCM0402  CL15 HEK-293T C45(1.01)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C45(0.95); C100(1.67)  LDD1607  [4]
 LDCM0405  CL18 HEK-293T C45(0.93)  LDD1609  [4]
 LDCM0409  CL21 HEK-293T C45(1.00)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C45(0.95)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C45(0.94)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C100(1.15)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C45(0.96)  LDD1617  [4]
 LDCM0415  CL27 HEK-293T C45(0.93)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C45(0.84); C100(1.55)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C45(1.05)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C45(0.92)  LDD1623  [4]
 LDCM0422  CL33 HEK-293T C45(0.90)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C45(0.54)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C45(0.93)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C100(1.06)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C45(0.95)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C45(1.08)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C45(0.85); C100(1.29)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C45(1.06); C100(1.22)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C45(0.90)  LDD1636  [4]
 LDCM0435  CL45 HEK-293T C45(0.85)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C45(0.91)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C45(0.91)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C100(0.74)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C45(0.80)  LDD1643  [4]
 LDCM0443  CL52 HEK-293T C45(1.04); C100(1.27)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C45(0.93)  LDD1648  [4]
 LDCM0448  CL57 HEK-293T C45(1.06)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C45(0.93)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C45(0.94)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C45(0.97)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C100(1.12)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C45(0.93)  LDD1656  [4]
 LDCM0455  CL63 HEK-293T C45(1.06)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C45(1.12); C100(1.53)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C45(1.00)  LDD1661  [4]
 LDCM0461  CL69 HEK-293T C45(0.87)  LDD1664  [4]
 LDCM0463  CL70 HEK-293T C45(1.05)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C45(0.91)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C100(0.85)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C45(0.84)  LDD1669  [4]
 LDCM0469  CL76 HEK-293T C45(0.82); C100(0.85)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C45(0.98)  LDD1674  [4]
 LDCM0475  CL81 HEK-293T C45(0.74)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C45(1.03)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C45(0.86)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C100(1.00)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C45(0.69)  LDD1682  [4]
 LDCM0481  CL87 HEK-293T C45(0.80)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C45(0.72); C100(1.00)  LDD1685  [4]
 LDCM0484  CL9 HEK-293T C45(0.95)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C45(0.99)  LDD1688  [4]
 LDCM0488  CL93 HEK-293T C45(0.84)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C45(0.92)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C45(0.91)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C100(1.07)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C45(0.95)  LDD1695  [4]
 LDCM0494  CL99 HEK-293T C45(0.98)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C45(1.10)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C45(0.92)  LDD1671  [4]
 LDCM0107  IAA HeLa H71(0.00); H104(0.00); H51(0.00)  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C45(1.07)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C45(0.87)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C45(1.02)  LDD1502  [4]
 LDCM0109  NEM HeLa H71(0.00); H51(0.00)  LDD0223  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C100(1.23)  LDD2125  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Immunoglobulin
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-2-microglobulin (B2M) Beta-2-microglobulin family P61769
Hereditary hemochromatosis protein (HFE) MHC class I family Q30201
Natural killer cell receptor 2B4 (CD244) . Q9BZW8
T-cell surface glycoprotein CD1a (CD1A) . P06126
T-cell surface glycoprotein CD1b (CD1B) . P29016
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proliferating cell nuclear antigen (PCNA) PCNA family P12004
Pygopus homolog 1 (PYGO1) . Q9Y3Y4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Opium . DB11130
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-formylmethionine Small molecular drug DB04464
3-indolebutyric Acid . DB02740

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264