Details of the Target

General Information of Target

Target ID LDTP04928
Target Name Rho-related GTP-binding protein RhoE (RND3)
Gene Name RND3
Gene ID 390
Synonyms
ARHE; RHO8; RHOE; Rho-related GTP-binding protein RhoE; Protein MemB; Rho family GTPase 3; Rho-related GTP-binding protein Rho8; Rnd3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENY
TASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGE
IQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSAL
QSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKS
CTVM
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rho family
Subcellular location
Golgi apparatus membrane
Function Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
Uniprot ID
P61587
Ensemble ID
ENST00000263895.9
HGNC ID
HGNC:671

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C197(1.09); C34(1.31); C135(1.73)  LDD3310  [1]
BTD
 Probe Info  		C197(0.90)  LDD2094  [2]
IPM
 Probe Info  		C135(1.11)  LDD1701  [2]
Acrolein
 Probe Info  		N.A.  LDD0227  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
IA-alkyne
 Probe Info  		C197(0.00); C34(0.00)  LDD0162  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C197(0.92)  LDD2112  [2]
 LDCM0214  AC1 HEK-293T C135(0.98)  LDD1507  [6]
 LDCM0259  AC14 HEK-293T C135(0.97)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C135(1.03)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C135(1.09)  LDD1515  [6]
 LDCM0282  AC22 HEK-293T C135(0.97)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C135(1.01)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C135(1.52)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C135(0.96)  LDD1524  [6]
 LDCM0291  AC30 HEK-293T C135(1.06)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C135(1.12)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C135(1.24)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C135(1.15)  LDD1533  [6]
 LDCM0299  AC38 HEK-293T C135(1.10)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C135(1.50)  LDD1539  [6]
 LDCM0302  AC40 HEK-293T C135(0.92)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C135(1.16)  LDD1542  [6]
 LDCM0308  AC46 HEK-293T C135(1.10)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C135(1.31)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C135(0.88)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C135(0.93)  LDD1550  [6]
 LDCM0317  AC54 HEK-293T C135(0.96)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C135(1.26)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C135(1.11)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C135(0.97)  LDD1559  [6]
 LDCM0323  AC6 HEK-293T C135(0.89)  LDD1562  [6]
 LDCM0326  AC62 HEK-293T C135(0.87)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C135(1.23)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C135(1.02)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C135(1.18)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C135(1.22)  LDD1569  [6]
 LDCM0356  AKOS034007680 HEK-293T C135(1.04)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C135(1.10)  LDD1514  [6]
 LDCM0368  CL10 HEK-293T C135(1.09)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C135(0.83)  LDD1573  [6]
 LDCM0373  CL104 HEK-293T C135(0.97)  LDD1577  [6]
 LDCM0377  CL108 HEK-293T C135(1.02)  LDD1581  [6]
 LDCM0379  CL11 HEK-293T C135(1.62)  LDD1583  [6]
 LDCM0382  CL112 HEK-293T C135(0.73)  LDD1586  [6]
 LDCM0386  CL116 HEK-293T C135(0.84)  LDD1590  [6]
 LDCM0390  CL12 HEK-293T C135(1.30)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C135(0.98)  LDD1595  [6]
 LDCM0395  CL124 HEK-293T C135(0.91)  LDD1599  [6]
 LDCM0399  CL128 HEK-293T C135(0.83)  LDD1603  [6]
 LDCM0403  CL16 HEK-293T C135(0.93)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C135(1.38)  LDD1608  [6]
 LDCM0410  CL22 HEK-293T C135(1.08)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C135(1.54)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C135(1.29)  LDD1616  [6]
 LDCM0416  CL28 HEK-293T C135(0.89)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C135(1.31)  LDD1621  [6]
 LDCM0423  CL34 HEK-293T C135(1.10)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C135(1.06)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C135(1.16)  LDD1629  [6]
 LDCM0429  CL4 HEK-293T C135(0.94)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C135(1.11)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C135(1.09)  LDD1635  [6]
 LDCM0436  CL46 HEK-293T C135(1.33)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C135(1.10)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C135(1.47)  LDD1642  [6]
 LDCM0440  CL5 HEK-293T C135(1.11)  LDD1644  [6]
 LDCM0443  CL52 HEK-293T C135(0.97)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C135(1.24)  LDD1647  [6]
 LDCM0449  CL58 HEK-293T C135(1.18)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C135(1.27)  LDD1653  [6]
 LDCM0452  CL60 HEK-293T C135(1.19)  LDD1655  [6]
 LDCM0456  CL64 HEK-293T C135(0.71)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C135(1.14)  LDD1660  [6]
 LDCM0463  CL70 HEK-293T C135(1.03)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C135(1.61)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C135(1.50)  LDD1668  [6]
 LDCM0469  CL76 HEK-293T C135(0.94)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C135(1.16)  LDD1673  [6]
 LDCM0476  CL82 HEK-293T C135(1.04)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C135(1.64)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C135(1.34)  LDD1681  [6]
 LDCM0482  CL88 HEK-293T C135(0.95)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C135(1.13)  LDD1686  [6]
 LDCM0489  CL94 HEK-293T C135(0.98)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C135(1.45)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C135(1.01)  LDD1694  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C135(1.35)  LDD1702  [2]
 LDCM0022  KB02 42-MG-BA C197(1.30); C125(0.94); C34(1.45); C177(1.24)  LDD2244  [1]
 LDCM0023  KB03 MDA-MB-231 C135(1.11)  LDD1701  [2]
 LDCM0024  KB05 COLO792 C197(1.09); C34(1.31); C135(1.73)  LDD3310  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C197(0.90)  LDD2094  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C197(2.06)  LDD2096  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C197(1.02)  LDD2141  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ciliogenesis and planar polarity effector 2 (CPLANE2) Rab family Q9BU20
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein beta/alpha (YWHAB) 14-3-3 family P31946
Plexin-B1 (PLXNB1) Plexin family O43157
Plexin-B2 (PLXNB2) Plexin family O15031
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-triphosphate Small molecular drug DB04137

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402