Details of the Target

General Information of Target

Target ID LDTP04808
Target Name Forkhead box protein L2 (FOXL2)
Gene Name FOXL2
Gene ID 668
Synonyms
Forkhead box protein L2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMASYPEPEDAAGALLAPETGRTVKEPEGPPPSPGKGGGGGGGTAPEKPDPAQKPPYSYV
ALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGG
GERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAGGAAGGCGVAG
AGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPG
AAAVVKGLAGPAASYGPYTRVQSMALPPGVVNSYNGLGGPPAAPPPPPHPHPHPHAHHLH
AAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSY
WDHDSKTGALHSRLDL
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Is a regulator of CYP19 expression. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Uniprot ID
P58012
Ensemble ID
ENST00000648323.1
HGNC ID
HGNC:1092

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C176(2.59)  LDD3331  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C176(0.85)  LDD1094  [5]
 LDCM0226  AC11 PaTu 8988t C176(1.07)  LDD1105  [5]
 LDCM0237  AC12 PaTu 8988t C176(0.70)  LDD1116  [5]
 LDCM0259  AC14 PaTu 8988t C176(0.48)  LDD1138  [5]
 LDCM0270  AC15 PaTu 8988t C176(0.70)  LDD1149  [5]
 LDCM0320  AC57 PaTu 8988t C176(0.91)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C176(0.74)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C176(1.00)  LDD1201  [5]
 LDCM0323  AC6 PaTu 8988t C176(0.58)  LDD1202  [5]
 LDCM0324  AC60 PaTu 8988t C176(0.92)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C176(0.90)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C176(1.00)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C176(0.94)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C176(0.86)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C176(0.84)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C176(1.23)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C176(0.72)  LDD1210  [5]
 LDCM0332  AC68 PaTu 8988t C176(1.09)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C176(1.17)  LDD1212  [5]
 LDCM0334  AC7 PaTu 8988t C176(0.45)  LDD1213  [5]
 LDCM0335  AC70 PaTu 8988t C176(1.26)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C176(1.03)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C176(1.05)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C176(1.20)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C176(1.35)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C176(0.94)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C176(1.04)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C176(1.16)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C176(1.11)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C176(1.08)  LDD1223  [5]
 LDCM0345  AC8 PaTu 8988t C176(0.69)  LDD1224  [5]
 LDCM0346  AC80 PaTu 8988t C176(1.31)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C176(1.25)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C176(1.01)  LDD1227  [5]
 LDCM0349  AC83 PaTu 8988t C176(0.83)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C176(0.84)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C176(0.85)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C176(1.03)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C176(1.02)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C176(0.93)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C176(0.97)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C176(0.98)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C176(0.92)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C176(0.97)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C176(1.02)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C176(0.90)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C176(1.07)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C176(1.03)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C176(0.84)  LDD1243  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C176(0.63)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C176(0.85)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C176(0.71)  LDD1154  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0370  CL101 PaTu 8988t C176(1.06)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C176(0.74)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C176(0.70)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C176(0.58)  LDD1252  [5]
 LDCM0396  CL125 PaTu 8988t C176(0.84)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C176(0.66)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C176(1.10)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C176(0.77)  LDD1278  [5]
 LDCM0420  CL31 PaTu 8988t C176(1.21)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C176(1.49)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C176(2.15)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C176(1.45)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C176(1.52)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C176(1.77)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C176(1.94)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C176(1.38)  LDD1307  [5]
 LDCM0430  CL40 PaTu 8988t C176(1.19)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C176(1.82)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C176(1.87)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C176(2.41)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C176(1.63)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C176(1.28)  LDD1314  [5]
 LDCM0436  CL46 PaTu 8988t C176(1.09)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C176(1.07)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C176(1.32)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C176(1.36)  LDD1318  [5]
 LDCM0441  CL50 PaTu 8988t C176(1.28)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C176(1.68)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C176(1.49)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C176(1.65)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C176(1.22)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C176(1.42)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C176(1.29)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C176(1.60)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C176(1.35)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C176(1.35)  LDD1329  [5]
 LDCM0452  CL60 PaTu 8988t C176(1.12)  LDD1331  [5]
 LDCM0427  Fragment51 PaTu 8988t C176(1.68)  LDD1306  [5]
 LDCM0107  IAA HeLa H104(0.00); C111(0.00)  LDD0221  [4]
 LDCM0022  KB02 MKN-1 C176(1.81)  LDD2497  [1]
 LDCM0023  KB03 MKN-1 C176(2.39)  LDD2914  [1]
 LDCM0024  KB05 MKN-1 C176(2.59)  LDD3331  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.