Details of the Target

General Information of Target

Target ID LDTP04432
Target Name N-acylglucosamine 2-epimerase (RENBP)
Gene Name RENBP
Gene ID 5973
Synonyms
N-acylglucosamine 2-epimerase; AGE; EC 5.1.3.8; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein; RnBP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQEHGGFFTCLGREGRVYD
DLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLLRYARVAPPGKKCAFVLTR
DGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEMMDQIVHWVQEDASGLGRPQL
QGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGDWCARRILQHVQRDGQAVLENVS
EGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDPELRAHVIDKFLLLPFHSGWDPDHG
GLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFLMGYSDSGDPVLLRLFYQVAEYTFRQF
RDPEYGEWFGYLSREGKVALSIKGGPFKGCFHVPRCLAMCEEMLGALLSRPAPAPSPAPT
PACRGAE
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
N-acylglucosamine 2-epimerase family
Function
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
TTD ID
T24588
Uniprot ID
P51606
DrugMap ID
TTZCG0Q
Ensemble ID
ENST00000393700.8
HGNC ID
HGNC:9959

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C249(2.65)  LDD3310  [1]
AHL-Pu-1
 Probe Info  		C390(2.85)  LDD0170  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C390(2.85)  LDD0170  [2]
 LDCM0214  AC1 HEK-293T C249(1.20)  LDD1507  [4]
 LDCM0226  AC11 HEK-293T C249(1.04)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C249(1.18)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C249(1.72)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C249(0.98)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C249(1.29)  LDD1515  [4]
 LDCM0278  AC19 HEK-293T C249(1.30)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C249(1.03)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C249(1.22)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C249(1.10)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C249(1.12)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C249(1.11)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C249(1.11)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C249(1.29)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C249(0.93)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C249(0.79)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C249(0.99)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C249(1.01)  LDD1531  [4]
 LDCM0294  AC33 HEK-293T C249(1.11)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C249(1.04)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C249(0.92)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C249(1.31)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C249(0.94)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C249(1.22)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C249(0.98)  LDD1540  [4]
 LDCM0303  AC41 HEK-293T C249(1.14)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C249(1.08)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C249(1.01)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C249(0.85)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C249(1.26)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C249(0.87)  LDD1548  [4]
 LDCM0311  AC49 HEK-293T C249(1.10)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C249(0.97)  LDD1551  [4]
 LDCM0314  AC51 HEK-293T C249(0.90)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C249(1.40)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C249(1.28)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C249(1.05)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C249(0.79)  LDD1557  [4]
 LDCM0320  AC57 HEK-293T C249(1.15)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C249(0.83)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C249(1.24)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C249(1.12)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C249(0.91)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C249(1.19)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C249(0.92)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C249(0.96)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C249(1.31)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C249(0.94)  LDD1570  [4]
 LDCM0367  CL1 HEK-293T C249(0.97)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C249(1.03)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C249(0.77)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C249(1.40)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C249(0.91)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C249(0.87)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C249(1.05)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C249(0.94)  LDD1579  [4]
 LDCM0377  CL108 HEK-293T C249(0.85)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C249(0.95)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C249(1.11)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C249(1.13)  LDD1584  [4]
 LDCM0382  CL112 HEK-293T C249(1.05)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C249(0.89)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C249(0.89)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C249(0.95)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C249(1.12)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C249(0.87)  LDD1592  [4]
 LDCM0391  CL120 HEK-293T C249(0.79)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C249(0.92)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C249(1.09)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C249(0.84)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C249(1.14)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C249(0.85)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C249(0.77)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C249(1.58)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C249(0.70)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C249(0.87)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C249(1.16)  LDD1608  [4]
 LDCM0406  CL19 HEK-293T C249(0.96)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C249(0.86)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C249(0.87)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C249(0.88)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C249(0.85)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C249(0.97)  LDD1615  [4]
 LDCM0413  CL25 HEK-293T C249(0.81)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C249(0.60)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C249(0.82)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C249(1.04)  LDD1621  [4]
 LDCM0420  CL31 HEK-293T C249(1.07)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C249(0.94)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C249(1.13)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C249(1.04)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C249(0.95)  LDD1628  [4]
 LDCM0426  CL37 HEK-293T C249(0.83)  LDD1630  [4]
 LDCM0429  CL4 HEK-293T C249(0.94)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C249(0.79)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C249(1.22)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C249(0.95)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C249(1.08)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C249(0.97)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C249(1.26)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C249(1.07)  LDD1641  [4]
 LDCM0439  CL49 HEK-293T C249(0.83)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C249(1.22)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C249(0.91)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C249(0.76)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C249(0.89)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C249(0.86)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C249(1.45)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C249(0.91)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C249(1.17)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C249(1.33)  LDD1653  [4]
 LDCM0453  CL61 HEK-293T C249(0.68)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C249(1.17)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C249(0.78)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C249(0.98)  LDD1660  [4]
 LDCM0459  CL67 HEK-293T C249(1.15)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C249(0.96)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C249(1.19)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C249(0.96)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C249(1.08)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C249(0.85)  LDD1667  [4]
 LDCM0466  CL73 HEK-293T C249(1.01)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C249(0.92)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C249(0.96)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C249(1.25)  LDD1673  [4]
 LDCM0472  CL79 HEK-293T C249(1.10)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C249(1.02)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C249(0.90)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C249(1.15)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C249(1.19)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C249(1.03)  LDD1680  [4]
 LDCM0479  CL85 HEK-293T C249(0.93)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C249(1.27)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C249(0.79)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C249(1.06)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C249(0.89)  LDD1687  [4]
 LDCM0486  CL91 HEK-293T C249(1.13)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C249(1.06)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C249(1.26)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C249(0.96)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C249(0.98)  LDD1693  [4]
 LDCM0492  CL97 HEK-293T C249(0.84)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C249(0.98)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C249(1.23)  LDD1631  [4]
 LDCM0022  KB02 22RV1 C249(2.33)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C249(2.48)  LDD2660  [1]
 LDCM0024  KB05 COLO792 C249(2.65)  LDD3310  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-acetylglucosamine Small molecular drug DB00141

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402