Details of the Target

General Information of Target

Target ID LDTP04193
Target Name Interferon alpha/beta receptor 2 (IFNAR2)
Gene Name IFNAR2
Gene ID 3455
Synonyms
IFNABR; IFNARB; Interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2; Interferon alpha binding protein; Type I interferon receptor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS
IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF
SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK
HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE
SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI
DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR
ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT
FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
Target Type
Successful
Target Bioclass
Cytokine and receptor
Family
Type II cytokine receptor family
Subcellular location
Secreted; Cell membrane
Function
Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.; [Isoform 3]: Potent inhibitor of type I IFN receptor activity.
TTD ID
T06421
Uniprot ID
P48551
DrugMap ID
TTMQB37
Ensemble ID
ENST00000342101.7
HGNC ID
HGNC:5433
ChEMBL ID
CHEMBL2364170

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.R46Q .
Ishikawa (Heraklio) 02 ER SNV: p.P289L .
JURKAT SNV: p.A352V .
MEWO SNV: p.P407S .
OAW28 Deletion: p.V24IfsTer24 .
TOV21G Deletion: p.K226NfsTer19 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C395(0.47)  LDD2184  [1]
DBIA
 Probe Info  		C85(1.03)  LDD1507  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C85(1.03)  LDD1507  [2]
 LDCM0237  AC12 HEK-293T C395(1.32)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C85(1.12)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C85(0.89)  LDD1515  [2]
 LDCM0280  AC20 HEK-293T C395(0.98)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C85(0.99)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C395(0.86)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C85(1.00)  LDD1524  [2]
 LDCM0288  AC28 HEK-293T C395(0.93)  LDD1527  [2]
 LDCM0292  AC31 HEK-293T C85(1.20)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C395(1.32)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C85(1.00)  LDD1533  [2]
 LDCM0297  AC36 HEK-293T C395(1.13)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C85(0.99)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C395(1.15)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C395(0.92)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C85(1.07)  LDD1542  [2]
 LDCM0306  AC44 HEK-293T C395(1.04)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C85(1.04)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C395(1.12)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C85(1.07)  LDD1550  [2]
 LDCM0315  AC52 HEK-293T C395(1.12)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C85(1.25)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C395(1.15)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C85(1.19)  LDD1559  [2]
 LDCM0324  AC60 HEK-293T C395(1.08)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C85(1.04)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C395(0.86)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C85(1.00)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C395(0.87)  LDD1569  [2]
 LDCM0356  AKOS034007680 HEK-293T C85(1.08)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C395(0.98)  LDD1514  [2]
 LDCM0379  CL11 HEK-293T C85(1.08)  LDD1583  [2]
 LDCM0390  CL12 HEK-293T C395(1.15)  LDD1594  [2]
 LDCM0404  CL17 HEK-293T C85(1.24)  LDD1608  [2]
 LDCM0408  CL20 HEK-293T C395(1.05)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C85(1.11)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C395(1.24)  LDD1616  [2]
 LDCM0417  CL29 HEK-293T C85(0.93)  LDD1621  [2]
 LDCM0421  CL32 HEK-293T C395(1.08)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C85(1.05)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C395(1.17)  LDD1629  [2]
 LDCM0431  CL41 HEK-293T C85(0.81)  LDD1635  [2]
 LDCM0434  CL44 HEK-293T C395(0.96)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C85(1.24)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C395(1.51)  LDD1642  [2]
 LDCM0440  CL5 HEK-293T C85(0.88)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C85(1.06)  LDD1647  [2]
 LDCM0447  CL56 HEK-293T C395(1.23)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C85(1.18)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C395(1.27)  LDD1655  [2]
 LDCM0457  CL65 HEK-293T C85(1.20)  LDD1660  [2]
 LDCM0460  CL68 HEK-293T C395(1.32)  LDD1663  [2]
 LDCM0464  CL71 HEK-293T C85(1.36)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C395(1.11)  LDD1668  [2]
 LDCM0470  CL77 HEK-293T C85(0.80)  LDD1673  [2]
 LDCM0473  CL8 HEK-293T C395(0.58)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C395(1.20)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C85(1.19)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C395(1.35)  LDD1681  [2]
 LDCM0483  CL89 HEK-293T C85(1.08)  LDD1686  [2]
 LDCM0487  CL92 HEK-293T C395(1.03)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C85(1.19)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C395(1.21)  LDD1694  [2]
 LDCM0625  F8 Ramos C395(1.10)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C395(0.65)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C395(0.81)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C395(2.51)  LDD2191  [1]
 LDCM0576  Fragment14 Ramos C395(0.24)  LDD2193  [1]
 LDCM0579  Fragment20 Ramos C395(1.44)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C395(2.44)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C395(0.85)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C395(1.27)  LDD2197  [1]
 LDCM0588  Fragment30 Ramos C395(1.35)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C395(0.68)  LDD2200  [1]
 LDCM0596  Fragment38 Ramos C395(1.01)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C395(0.47)  LDD2184  [1]
 LDCM0569  Fragment7 Ramos C395(0.80)  LDD2186  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubl carboxyl-terminal hydrolase 18 (USP18) Peptidase C19 family Q9UMW8
Tyrosine-protein kinase JAK1 (JAK1) Tyr protein kinase family P23458
CREB-binding protein (CREBBP) . Q92793
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein RACK1 (RACK1) WD repeat G protein beta family P63244
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 9 (IRF9) IRF family Q00978
Signal transducer and activator of transcription 1-alpha/beta (STAT1) Transcription factor STAT family P42224
Signal transducer and activator of transcription 2 (STAT2) Transcription factor STAT family P52630
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon alpha-2 (IFNA2) Alpha/beta interferon family P01563

The Drug(s) Related To This Target

Approved
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sifalimumab Antibody D05NDR
Interferon Alfa-2a BiotechDrug DB00034
Interferon Alfa-n3 BiotechDrug DB00018
Peginterferon Alfa-2a BiotechDrug DB00008
Peginterferon Alfa-2b BiotechDrug DB00022
Interferon Alfa-2b Protein/peptide DB00105
Interferon Beta-1a Protein/peptide DB00060
Interferon Alfa-2b, Recombinant . D04RZD
Interferon Alfa-n1 . D03QCW
Interferon Alfacon-1 . D0GA0A
Interferon Beta-1b . D0CQ2O
Nylidrin . DB06152
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anifrolumab . D0FU8R
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alfa-interferon . D0SX9C
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Human Interferon Omega-1 . DB05472

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853