Details of the Target

General Information of Target

Target ID LDTP04160
Target Name Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)
Gene Name SLC6A9
Gene ID 6536
Synonyms
Sodium- and chloride-dependent glycine transporter 1; GlyT-1; GlyT1; Solute carrier family 6 member 9
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A9 subfamily
Subcellular location
Cell membrane
Function
Sodium- and chloride-dependent glycine transporter. Essential for regulating glycine concentrations at inhibitory glycinergic synapses.; [Isoform GlyT-1B]: Sodium- and chloride-dependent glycine transporter.; [Isoform GlyT-1C]: Sodium- and chloride-dependent glycine transporter.
TTD ID
T69685
Uniprot ID
P48067
DrugMap ID
TTHJTF7
Ensemble ID
ENST00000357730.6
HGNC ID
HGNC:11056
ChEMBL ID
CHEMBL2337

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K645(4.92)  LDD0277  [1]
DBIA
 Probe Info  		C498(1.10)  LDD3383  [2]
IA-alkyne
 Probe Info  		C130(1.35)  LDD2182  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C130(0.92)  LDD1507  [6]
 LDCM0259  AC14 HEK-293T C130(0.97)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C130(0.87)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C130(0.95)  LDD1515  [6]
 LDCM0282  AC22 HEK-293T C130(0.87)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C130(0.85)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C392(0.90)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C130(0.89)  LDD1524  [6]
 LDCM0291  AC30 HEK-293T C130(0.82)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C130(0.79)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C392(0.90)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C130(0.95)  LDD1533  [6]
 LDCM0299  AC38 HEK-293T C130(0.94)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C130(0.80)  LDD1539  [6]
 LDCM0302  AC40 HEK-293T C392(0.94)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C130(0.91)  LDD1542  [6]
 LDCM0308  AC46 HEK-293T C130(0.96)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C130(0.78)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C392(0.95)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C130(0.84)  LDD1550  [6]
 LDCM0317  AC54 HEK-293T C130(0.96)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C130(0.89)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C392(0.94)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C130(0.98)  LDD1559  [6]
 LDCM0323  AC6 HEK-293T C130(1.00)  LDD1562  [6]
 LDCM0326  AC62 HEK-293T C130(0.93)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C130(0.82)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C392(0.94)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C130(0.88)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C392(0.96)  LDD1569  [6]
 LDCM0356  AKOS034007680 HEK-293T C130(0.87)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C392(0.98)  LDD1514  [6]
 LDCM0368  CL10 HEK-293T C130(1.64)  LDD1572  [6]
 LDCM0372  CL103 HEK-293T C130(1.00)  LDD1576  [6]
 LDCM0376  CL107 HEK-293T C130(1.04)  LDD1580  [6]
 LDCM0379  CL11 HEK-293T C130(0.80)  LDD1583  [6]
 LDCM0381  CL111 HEK-293T C130(1.06)  LDD1585  [6]
 LDCM0385  CL115 HEK-293T C130(0.84)  LDD1589  [6]
 LDCM0389  CL119 HEK-293T C130(0.85)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C392(1.29)  LDD1594  [6]
 LDCM0394  CL123 HEK-293T C130(1.01)  LDD1598  [6]
 LDCM0398  CL127 HEK-293T C130(0.98)  LDD1602  [6]
 LDCM0402  CL15 HEK-293T C130(0.99)  LDD1606  [6]
 LDCM0404  CL17 HEK-293T C130(1.04)  LDD1608  [6]
 LDCM0410  CL22 HEK-293T C130(1.10)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C130(0.76)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C392(1.39)  LDD1616  [6]
 LDCM0415  CL27 HEK-293T C130(0.96)  LDD1619  [6]
 LDCM0417  CL29 HEK-293T C130(0.97)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C130(1.21)  LDD1622  [6]
 LDCM0423  CL34 HEK-293T C130(1.00)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C130(0.85)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C392(1.21)  LDD1629  [6]
 LDCM0428  CL39 HEK-293T C130(0.98)  LDD1632  [6]
 LDCM0431  CL41 HEK-293T C130(0.94)  LDD1635  [6]
 LDCM0436  CL46 HEK-293T C130(1.04)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C130(0.76)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C392(1.25)  LDD1642  [6]
 LDCM0440  CL5 HEK-293T C130(0.96)  LDD1644  [6]
 LDCM0444  CL53 HEK-293T C130(0.96)  LDD1647  [6]
 LDCM0449  CL58 HEK-293T C130(1.20)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C130(0.86)  LDD1653  [6]
 LDCM0452  CL60 HEK-293T C392(1.22)  LDD1655  [6]
 LDCM0455  CL63 HEK-293T C130(0.99)  LDD1658  [6]
 LDCM0457  CL65 HEK-293T C130(0.82)  LDD1660  [6]
 LDCM0463  CL70 HEK-293T C130(0.97)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C130(0.93)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C392(1.29)  LDD1668  [6]
 LDCM0470  CL77 HEK-293T C130(1.00)  LDD1673  [6]
 LDCM0476  CL82 HEK-293T C130(0.82)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C130(0.80)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C392(1.20)  LDD1681  [6]
 LDCM0481  CL87 HEK-293T C130(0.95)  LDD1684  [6]
 LDCM0483  CL89 HEK-293T C130(0.98)  LDD1686  [6]
 LDCM0489  CL94 HEK-293T C130(1.06)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C130(0.83)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C392(1.30)  LDD1694  [6]
 LDCM0494  CL99 HEK-293T C130(0.88)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C130(1.05)  LDD1698  [6]
 LDCM0625  F8 Ramos C130(1.45)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C130(1.49)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C130(4.97)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C130(3.54)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C130(0.95)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C130(1.48)  LDD2193  [3]
 LDCM0580  Fragment21 Ramos C130(0.81)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C130(0.77)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C130(0.67)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C130(1.24)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C130(1.00)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C130(1.45)  LDD2200  [3]
 LDCM0468  Fragment33 HEK-293T C130(1.14)  LDD1671  [6]
 LDCM0596  Fragment38 Ramos C130(3.61)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C130(1.62)  LDD2184  [3]
 LDCM0610  Fragment52 Ramos C130(1.24)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C130(0.71)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C130(1.08)  LDD2186  [3]
 LDCM0022  KB02 Ramos C130(1.35)  LDD2182  [3]
 LDCM0023  KB03 A2780 C498(1.36)  LDD2671  [2]
 LDCM0024  KB05 OVCAR-5 C498(1.10)  LDD3383  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glycine Small molecular drug DB00145
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bi 425809 Small molecular drug D76PDV
R1678 Small molecular drug D0B6IZ
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Org-25935 Small molecular drug D0LT0U
Amg 747 . D04NIZ
Pf-3463275 . D0O0BM
Phase 1
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alx-5407 Small molecular drug D05WWJ
Dcccyb Small molecular drug D0R8HY
Glyt1 Pet Radiotracers . D02XSL
Jnj-17305600 . D0F4NP
Mk-2637 . D0Y3AZ
Preclinical
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Org-24461 Small molecular drug D0U1HP
Organon Small molecular drug D07PNC
Ssr-504734 Small molecular drug D06SBS
Organon-2 . D0O5ZT
Organon-3 . D0I6JG
Ssr-103800 . D0Y9KR
Investigative
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk931145 Small molecular drug D07PKH
Ly2365109 Small molecular drug D0U1CN
[35s]Acppb Small molecular drug D09FDV
[3h](R)-npts Small molecular drug D07IYZ
[3h]Gsk931145 Small molecular drug D0O8LR
[3h]N-methyl-ssr504734 Small molecular drug D0GI5V
[3h]Nfps Small molecular drug D08AYM
[3h]Sb-733993 Small molecular drug D0H7RV
As-1522489-00 . D0I5ZO
Ro-4840700 . D00CFU
Patented
Click To Hide/Show 33 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid29338548-compound-13 Small molecular drug D0H2KL
Pmid29338548-compound-14 Small molecular drug D0I7AJ
Pmid29338548-compound-15 Small molecular drug D0EV6V
Pmid29338548-compound-16 Small molecular drug D0K6CM
Pmid29338548-compound-17 Small molecular drug D02TZT
Pmid29338548-compound-18 Small molecular drug D08GXR
Pmid29338548-compound-19 Small molecular drug D0Y9FA
Pmid29338548-compound-20 Small molecular drug D0S6BG
Pmid29338548-compound-21 Small molecular drug D0W7FS
Pmid29338548-compound-22 Small molecular drug D0T2QP
Pmid29338548-compound-23 Small molecular drug D0EF0P
Pmid29338548-compound-24 Small molecular drug D00JEC
Pmid29338548-compound-25 Small molecular drug D01IJO
Pmid29338548-compound-26 Small molecular drug D0FG2H
Pmid29338548-compound-27 Small molecular drug D0H5VO
Pmid29338548-compound-28 Small molecular drug D0X1ZA
Pmid29338548-compound-29 Small molecular drug D08UQK
Pmid29338548-compound-30 Small molecular drug D0H5WE
Pmid29338548-compound-31 Small molecular drug D07GSH
Pmid29338548-compound-33 Small molecular drug D0T1BE
Pmid29338548-compound-34 Small molecular drug D0GX8J
Pmid29338548-compound-36 Small molecular drug D0E2VI
Pmid29338548-compound-37 Small molecular drug D0WT3F
Pmid29338548-compound-38 Small molecular drug D03PQS
Pmid29338548-compound-39 Small molecular drug D06OSE
Pmid29338548-compound-40 Small molecular drug D0W2YK
Pmid29338548-compound-41 Small molecular drug D06BUG
Pmid29338548-compound-44 Small molecular drug D0M6PI
Pmid29338548-compound-45 Small molecular drug D0V5KY
Pmid29338548-compound-46 Small molecular drug D0B5NJ
Pmid29338548-compound-47 Small molecular drug D0XS1I
Pmid29338548-compound-48 Small molecular drug D0MT4C
Pmid29338548-compound-49 Small molecular drug D0XG8H
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk1018921 . D0WY2L

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402