Details of the Target

General Information of Target

Target ID LDTP02880
Target Name Zinc finger protein 3 (ZNF3)
Gene Name ZNF3
Gene ID 7551
Synonyms
KOX25; Zinc finger protein 3; Zinc finger protein HF.12; Zinc finger protein HZF3.1; Zinc finger protein KOX25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METQADLVSQEPQALLDSALPSKVPAFSDKDSLGDEMLAAALLKAKSQELVTFEDVAVYF
IRKEWKRLEPAQRDLYRDVMLENYGNVFSLDRETRTENDQEISEDTRSHGVLLGRFQKDI
SQGLKFKEAYEREVSLKRPLGNSPGERLNRKMPDFGQVTVEEKLTPRGERSEKYNDFGNS
FTVNSNLISHQRLPVGDRPHKCDECSKSFNRTSDLIQHQRIHTGEKPYECNECGKAFSQS
SHLIQHQRIHTGEKPYECSDCGKTFSCSSALILHRRIHTGEKPYECNECGKTFSWSSTLT
HHQRIHTGEKPYACNECGKAFSRSSTLIHHQRIHTGEKPYECNECGKAFSQSSHLYQHQR
IHTGEKPYECMECGGKFTYSSGLIQHQRIHTGENPYECSECGKAFRYSSALVRHQRIHTG
EKPLNGIGMSKSSLRVTTELNIREST
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Involved in cell differentiation and/or proliferation.
Uniprot ID
P17036
Ensemble ID
ENST00000299667.9
HGNC ID
HGNC:13089

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.Q13R .
MCC26 SNV: p.Q303Ter .
MEWO SNV: p.G426R .
MFE319 SNV: p.Y59H .
MOLT4 SNV: p.R416K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C267(0.90)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C267(0.90)  LDD0531  [1]
 LDCM0276  AC17 HCT 116 C267(1.29)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C267(0.84)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C267(0.80)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C267(0.92)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C267(0.84)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C267(0.85)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C267(0.99)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C267(0.86)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C267(0.89)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C267(1.06)  LDD1524  [2]
 LDCM0290  AC3 HCT 116 C267(0.93)  LDD0607  [1]
 LDCM0294  AC33 HEK-293T C267(1.05)  LDD1533  [2]
 LDCM0301  AC4 HCT 116 C267(0.90)  LDD0618  [1]
 LDCM0303  AC41 HEK-293T C267(1.14)  LDD1542  [2]
 LDCM0311  AC49 HEK-293T C267(1.10)  LDD1550  [2]
 LDCM0312  AC5 HCT 116 C267(0.97)  LDD0629  [1]
 LDCM0320  AC57 HCT 116 C267(1.06)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C267(1.37)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C267(1.13)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C267(1.56)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C267(1.04)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C267(1.17)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C267(1.06)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C267(1.17)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C267(0.98)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C267(1.12)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C267(0.85)  LDD0648  [1]
 LDCM0356  AKOS034007680 HEK-293T C267(1.15)  LDD1570  [2]
 LDCM0369  CL100 HCT 116 C267(0.92)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C267(0.76)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C267(0.64)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C267(0.82)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C267(0.78)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C267(0.77)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C267(1.06)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C267(0.94)  LDD0698  [1]
 LDCM0396  CL125 HCT 116 C267(1.13)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C267(1.37)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C267(1.52)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C267(0.91)  LDD0716  [1]
 LDCM0404  CL17 HEK-293T C267(1.16)  LDD1608  [2]
 LDCM0417  CL29 HEK-293T C267(1.08)  LDD1621  [2]
 LDCM0420  CL31 HCT 116 C267(0.97)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C267(0.96)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C267(1.08)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C267(0.96)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C267(1.21)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C267(1.15)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C267(1.18)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C267(1.01)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C267(1.33)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C267(0.96)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C267(1.13)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C267(1.05)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C267(1.01)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C267(0.95)  LDD0752  [1]
 LDCM0440  CL5 HEK-293T C267(1.24)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C267(1.36)  LDD1647  [2]
 LDCM0457  CL65 HEK-293T C267(1.03)  LDD1660  [2]
 LDCM0470  CL77 HEK-293T C267(1.32)  LDD1673  [2]
 LDCM0483  CL89 HEK-293T C267(1.15)  LDD1686  [2]
 LDCM0486  CL91 HCT 116 C267(1.03)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C267(0.92)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C267(0.88)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C267(0.79)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C267(0.93)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C267(1.02)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C267(1.18)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C267(1.01)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C267(0.97)  LDD0811  [1]
 LDCM0427  Fragment51 HCT 116 C267(1.39)  LDD0744  [1]
 LDCM0022  KB02 A2780 C267(1.79)  LDD2254  [3]
 LDCM0023  KB03 A2780 C267(1.74)  LDD2671  [3]
 LDCM0024  KB05 IGR37 C267(2.01)  LDD3314  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840