Details of the Target

General Information of Target

Target ID LDTP02490
Target Name Ras-related protein R-Ras (RRAS)
Gene Name RRAS
Gene ID 6237
Synonyms
Ras-related protein R-Ras; EC 3.6.5.-; p23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP
TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG
KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD
EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Ras family
Subcellular location
Cell membrane
Function Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.
Uniprot ID
P10301
Ensemble ID
ENST00000246792.4
HGNC ID
HGNC:10447

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.33  LDD0402  [1]
STPyne
 Probe Info  		K31(1.31)  LDD0277  [2]
DBIA
 Probe Info  		C70(10.61)  LDD0209  [3]
IPM
 Probe Info  		C70(1.27)  LDD1702  [4]
Acrolein
 Probe Info  		H165(0.00); H164(0.00)  LDD0227  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
AOyne
 Probe Info  		13.10  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C70(1.06)  LDD1507  [9]
 LDCM0215  AC10 HCT 116 C70(1.15)  LDD0532  [10]
 LDCM0226  AC11 HCT 116 C70(1.06)  LDD0543  [10]
 LDCM0237  AC12 HCT 116 C70(1.09)  LDD0554  [10]
 LDCM0259  AC14 HCT 116 C70(1.16)  LDD0576  [10]
 LDCM0263  AC143 HCT 116 C70(1.07)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C70(1.13)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C70(1.38)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C70(2.00)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C70(1.05)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C70(1.56)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C70(1.72)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C70(1.21)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C70(1.54)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C70(1.17)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C70(1.37)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C70(2.49)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C70(1.54)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C70(1.82)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C70(1.63)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C70(1.57)  LDD2161  [10]
 LDCM0276  AC17 HEK-293T C70(1.16)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C70(0.99)  LDD1516  [9]
 LDCM0279  AC2 HEK-293T C70(0.99)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C70(1.08)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C70(1.29)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C70(0.93)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C70(0.98)  LDD1522  [9]
 LDCM0285  AC25 HEK-293T C70(1.05)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C70(1.07)  LDD1525  [9]
 LDCM0288  AC28 HEK-293T C70(1.00)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C70(1.24)  LDD1528  [9]
 LDCM0291  AC30 HEK-293T C70(1.05)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C70(1.13)  LDD1531  [9]
 LDCM0294  AC33 HEK-293T C70(0.83)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C70(0.95)  LDD1534  [9]
 LDCM0296  AC35 HCT 116 C70(1.21)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C70(1.11)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C70(1.26)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C70(1.06)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C70(1.02)  LDD0617  [10]
 LDCM0301  AC4 HEK-293T C70(1.05)  LDD1540  [9]
 LDCM0302  AC40 HCT 116 C70(0.73)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C70(1.19)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C70(0.84)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C70(1.15)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C70(0.90)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C70(0.74)  LDD0624  [10]
 LDCM0308  AC46 HEK-293T C70(0.98)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C70(0.95)  LDD1548  [9]
 LDCM0311  AC49 HEK-293T C70(0.93)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C70(1.38)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C70(0.98)  LDD1552  [9]
 LDCM0315  AC52 HEK-293T C70(1.23)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C70(1.21)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C70(0.92)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C70(1.00)  LDD1557  [9]
 LDCM0320  AC57 HEK-293T C70(0.90)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C70(0.95)  LDD1560  [9]
 LDCM0323  AC6 HCT 116 C70(1.12)  LDD0640  [10]
 LDCM0324  AC60 HEK-293T C70(0.93)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C70(1.49)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C70(1.01)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C70(1.07)  LDD1566  [9]
 LDCM0334  AC7 HCT 116 C70(1.21)  LDD0651  [10]
 LDCM0345  AC8 HCT 116 C70(1.12)  LDD0662  [10]
 LDCM0349  AC83 HCT 116 C70(0.53)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C70(0.73)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C70(1.29)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C70(0.88)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C70(1.22)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C70(1.09)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C70(0.69)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C70(1.24)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C70(0.47)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C70(0.54)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C70(1.02)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C70(0.92)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C70(1.19)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C70(0.99)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C70(0.55)  LDD0681  [10]
 LDCM0248  AKOS034007472 HCT 116 C70(1.07)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C70(1.04)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C70(1.10)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.88  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C70(0.85)  LDD1246  [10]
 LDCM0368  CL10 PaTu 8988t C70(0.63)  LDD1247  [10]
 LDCM0369  CL100 HEK-293T C70(0.61)  LDD1573  [9]
 LDCM0370  CL101 HCT 116 C70(0.99)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C70(0.98)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C70(1.14)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C70(1.13)  LDD0690  [10]
 LDCM0374  CL105 HEK-293T C70(0.87)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C70(0.89)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C70(1.13)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C70(0.94)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C70(0.83)  LDD1582  [9]
 LDCM0379  CL11 PaTu 8988t C70(1.01)  LDD1258  [10]
 LDCM0380  CL110 HEK-293T C70(1.01)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C70(1.14)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C70(1.06)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C70(0.88)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C70(0.83)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C70(1.10)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C70(0.88)  LDD1590  [9]
 LDCM0387  CL117 HCT 116 C70(0.65)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C70(1.03)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C70(0.82)  LDD0706  [10]
 LDCM0390  CL12 PaTu 8988t C70(0.79)  LDD1269  [10]
 LDCM0391  CL120 HCT 116 C70(1.04)  LDD0708  [10]
 LDCM0392  CL121 HEK-293T C70(1.06)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C70(0.87)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C70(1.56)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C70(0.86)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C70(0.95)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C70(0.91)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C70(0.83)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C70(0.79)  LDD1603  [9]
 LDCM0400  CL13 PaTu 8988t C70(0.66)  LDD1279  [10]
 LDCM0401  CL14 PaTu 8988t C70(0.73)  LDD1280  [10]
 LDCM0402  CL15 PaTu 8988t C70(0.66)  LDD1281  [10]
 LDCM0403  CL16 PaTu 8988t C70(0.55)  LDD1282  [10]
 LDCM0404  CL17 PaTu 8988t C70(0.50)  LDD1283  [10]
 LDCM0405  CL18 PaTu 8988t C70(0.50)  LDD1284  [10]
 LDCM0406  CL19 PaTu 8988t C70(0.46)  LDD1285  [10]
 LDCM0407  CL2 PaTu 8988t C70(0.87)  LDD1286  [10]
 LDCM0408  CL20 PaTu 8988t C70(0.47)  LDD1287  [10]
 LDCM0409  CL21 PaTu 8988t C70(0.48)  LDD1288  [10]
 LDCM0410  CL22 PaTu 8988t C70(0.49)  LDD1289  [10]
 LDCM0411  CL23 PaTu 8988t C70(0.49)  LDD1290  [10]
 LDCM0412  CL24 PaTu 8988t C70(0.55)  LDD1291  [10]
 LDCM0413  CL25 PaTu 8988t C70(0.79)  LDD1292  [10]
 LDCM0414  CL26 PaTu 8988t C70(0.49)  LDD1293  [10]
 LDCM0415  CL27 PaTu 8988t C70(0.60)  LDD1294  [10]
 LDCM0416  CL28 PaTu 8988t C70(0.53)  LDD1295  [10]
 LDCM0417  CL29 PaTu 8988t C70(0.53)  LDD1296  [10]
 LDCM0418  CL3 PaTu 8988t C70(0.85)  LDD1297  [10]
 LDCM0419  CL30 PaTu 8988t C70(0.76)  LDD1298  [10]
 LDCM0420  CL31 PaTu 8988t C70(1.06)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C70(0.78)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C70(0.55)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C70(0.76)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C70(0.65)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C70(1.05)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C70(0.58)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C70(1.11)  LDD1307  [10]
 LDCM0429  CL4 PaTu 8988t C70(0.88)  LDD1308  [10]
 LDCM0430  CL40 PaTu 8988t C70(0.90)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C70(0.54)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C70(0.50)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C70(0.58)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C70(0.60)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C70(0.87)  LDD1314  [10]
 LDCM0436  CL46 HEK-293T C70(1.04)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C70(1.53)  LDD1641  [9]
 LDCM0439  CL49 HEK-293T C70(0.90)  LDD1643  [9]
 LDCM0440  CL5 PaTu 8988t C70(0.64)  LDD1319  [10]
 LDCM0441  CL50 HEK-293T C70(0.96)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C70(0.90)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C70(0.88)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C70(1.06)  LDD1648  [9]
 LDCM0447  CL56 HEK-293T C70(1.21)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C70(1.61)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C70(1.07)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C70(1.14)  LDD1653  [9]
 LDCM0451  CL6 PaTu 8988t C70(0.64)  LDD1330  [10]
 LDCM0453  CL61 PaTu 8988t C70(1.29)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C70(1.54)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C70(1.38)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C70(1.13)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C70(1.05)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C70(0.88)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C70(0.68)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C70(0.81)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C70(0.76)  LDD1340  [10]
 LDCM0462  CL7 PaTu 8988t C70(0.61)  LDD1341  [10]
 LDCM0463  CL70 PaTu 8988t C70(0.75)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C70(1.42)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C70(2.45)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C70(0.80)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C70(1.68)  LDD1346  [10]
 LDCM0469  CL76 PaTu 8988t C70(1.70)  LDD1348  [10]
 LDCM0470  CL77 PaTu 8988t C70(1.24)  LDD1349  [10]
 LDCM0471  CL78 PaTu 8988t C70(1.02)  LDD1350  [10]
 LDCM0472  CL79 PaTu 8988t C70(1.14)  LDD1351  [10]
 LDCM0473  CL8 PaTu 8988t C70(0.76)  LDD1352  [10]
 LDCM0474  CL80 PaTu 8988t C70(1.86)  LDD1353  [10]
 LDCM0475  CL81 PaTu 8988t C70(1.13)  LDD1354  [10]
 LDCM0476  CL82 PaTu 8988t C70(1.13)  LDD1355  [10]
 LDCM0477  CL83 PaTu 8988t C70(0.95)  LDD1356  [10]
 LDCM0478  CL84 PaTu 8988t C70(0.69)  LDD1357  [10]
 LDCM0479  CL85 PaTu 8988t C70(1.23)  LDD1358  [10]
 LDCM0480  CL86 PaTu 8988t C70(1.33)  LDD1359  [10]
 LDCM0481  CL87 PaTu 8988t C70(0.94)  LDD1360  [10]
 LDCM0482  CL88 PaTu 8988t C70(0.94)  LDD1361  [10]
 LDCM0483  CL89 PaTu 8988t C70(0.67)  LDD1362  [10]
 LDCM0484  CL9 PaTu 8988t C70(0.64)  LDD1363  [10]
 LDCM0485  CL90 PaTu 8988t C70(0.76)  LDD1364  [10]
 LDCM0487  CL92 HEK-293T C70(0.92)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C70(1.52)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C70(1.07)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C70(1.06)  LDD1693  [9]
 LDCM0492  CL97 HEK-293T C70(0.88)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C70(1.05)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C70(1.30)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C70(0.98)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C70(1.27)  LDD1702  [4]
 LDCM0468  Fragment33 PaTu 8988t C70(0.84)  LDD1347  [10]
 LDCM0427  Fragment51 PaTu 8988t C70(0.65)  LDD1306  [10]
 LDCM0022  KB02 HEK-293T C70(0.95)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C70(10.61)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C70(1.79)  LDD3310  [11]
 LDCM0109  NEM HeLa H165(0.00); H164(0.00)  LDD0227  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840