Details of the Target

General Information of Target

Target ID LDTP02259
Target Name Mineralocorticoid receptor (NR3C2)
Gene Name NR3C2
Gene ID 4306
Synonyms
MCR; MLR; Mineralocorticoid receptor; MR; Nuclear receptor subfamily 3 group C member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
Target Type
Successful
Target Bioclass
Transcription factor
Family
Nuclear hormone receptor family, NR3 subfamily
Subcellular location
Cytoplasm
Function
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
TTD ID
T72168
Uniprot ID
P08235
DrugMap ID
TT9P1CK
Ensemble ID
ENST00000342437.8
HGNC ID
HGNC:7979
ChEMBL ID
CHEMBL1994

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.I602T .
HCC1419 SNV: p.S522P DBIA    Probe Info 
HSC4 SNV: p.K628Ter .
IGROV1 SNV: p.P81S .
LN18 SNV: p.N305K .
MCC13 SNV: p.P490S .
MCC26 SNV: p.P747L .
MFE319 SNV: p.A25V .
MKN45 SNV: p.P695T .
SAOS2 SNV: p.Q688R .
SKNMC SNV: p.F956L .
SW1271 SNV: p.M453I .
TOV21G SNV: p.G412R .
VMRCRCW SNV: p.N47H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C649(2.41)  LDD3319  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
AOyne
 Probe Info  		14.50  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C645(0.89); C639(0.92)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C645(1.10); C639(0.95); C436(0.93)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C645(1.13); C639(0.99); C187(0.94); C663(1.08)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C645(1.03); C639(0.64)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C645(1.17); C639(0.80); C663(1.00)  LDD1512  [6]
 LDCM0276  AC17 HEK-293T C645(1.01); C639(0.98)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C645(0.92); C639(0.93); C436(0.96)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C645(1.40); C639(1.35); C187(1.44); C663(1.20)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C645(1.03); C639(1.00); C436(0.88)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C645(1.07); C639(0.92)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C639(0.92)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C645(1.01); C639(1.49); C663(1.03)  LDD1521  [6]
 LDCM0284  AC24 HEK-293T C645(1.05); C436(1.03); C910(0.85); C663(0.97)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C645(1.22); C639(0.95)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C645(1.02); C639(1.05); C436(1.15)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C645(1.01); C639(0.96); C187(0.93); C663(1.14)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C645(0.95); C639(0.96)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C639(1.04)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C645(0.96); C639(1.02); C187(1.01); C663(0.77)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C645(1.02); C639(1.33); C663(0.83)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C645(1.07); C436(1.02); C910(1.34); C663(1.00)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C645(1.25); C639(0.96)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C645(1.10); C639(0.99); C436(1.05)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C645(1.07); C639(0.98); C187(1.09); C663(1.11)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C645(1.03); C639(0.91)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C639(0.86)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C645(1.09); C639(0.94); C663(0.97)  LDD1538  [6]
 LDCM0301  AC4 HEK-293T C645(0.96); C639(0.83)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C645(1.12); C436(1.03); C910(1.35); C663(1.12)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C645(1.24); C639(0.91)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C645(1.09); C639(0.96); C436(1.22)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C645(1.09); C639(0.98); C187(0.98); C663(1.10)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C645(1.02); C639(1.04)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C639(1.25)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C645(1.09); C639(0.93); C663(0.89)  LDD1547  [6]
 LDCM0310  AC48 HEK-293T C645(1.03); C436(1.01); C910(1.02); C663(0.96)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C645(1.11); C639(1.02)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C639(1.05)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C645(1.11); C639(0.96); C436(0.99)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C645(1.03); C639(0.98); C187(0.89); C663(1.11)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C645(1.09); C639(0.74)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C639(1.01)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C645(1.08); C639(0.88); C663(1.11)  LDD1556  [6]
 LDCM0319  AC56 HEK-293T C645(1.19); C436(0.98); C910(0.85); C663(0.92)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C645(1.33); C639(0.93)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C645(1.07); C639(0.98); C436(0.90)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C645(1.06); C639(0.90); C187(0.93); C663(1.15)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C645(1.08); C639(1.06); C663(0.77)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C645(1.06); C639(0.98)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C639(1.18)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C645(1.02); C639(0.80); C663(0.93)  LDD1565  [6]
 LDCM0328  AC64 HEK-293T C645(1.15); C436(0.92); C910(1.13); C663(1.12)  LDD1567  [6]
 LDCM0345  AC8 HEK-293T C645(0.96); C436(1.08); C910(0.88); C663(0.88)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C639(0.99)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C645(1.29); C639(0.92)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C645(0.99); C436(1.00); C910(0.96); C663(0.96)  LDD1514  [6]
 LDCM0108  Chloroacetamide HeLa C639(0.00); C645(0.00)  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C645(1.10)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C645(1.12); C639(0.90); C663(1.02)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C645(1.12); C639(0.88)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C645(1.05)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C645(1.13); C639(1.05)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C645(1.12); C639(1.03); C436(1.05)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C645(1.30); C639(0.84)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C645(1.18)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C645(1.11); C639(0.95)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C645(1.02); C639(0.97); C436(0.96)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C645(1.05); C639(0.96)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C645(1.10)  LDD1582  [6]
 LDCM0380  CL110 HEK-293T C645(1.22); C639(0.94)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C645(1.04); C639(0.96); C436(1.00)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C645(1.06); C639(0.95)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C645(1.05)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C645(1.23); C639(1.01)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C645(1.15); C639(1.04); C436(1.06)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C645(1.21); C639(0.97)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C645(1.10)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C645(1.28); C639(1.05)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C645(1.16); C639(1.04); C436(1.03)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C645(1.12); C436(1.04); C910(1.12); C663(1.14)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C645(1.31); C639(0.94)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C645(1.18)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C645(1.23); C639(1.01)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C645(1.02); C639(0.97); C436(0.94)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C645(1.46); C639(0.93)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C645(1.10)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C645(1.09); C639(0.93)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C645(1.24); C639(1.00); C436(0.92)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C645(1.07); C639(1.06)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C645(1.09)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C645(1.06); C639(0.96)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C645(1.38); C639(0.95); C436(1.00)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C645(1.30); C639(0.99)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C645(1.17); C639(1.04)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C645(1.17); C639(0.95); C436(0.88)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C645(1.16); C639(0.99); C187(1.05); C663(1.11)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C645(1.04); C639(1.00)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C645(1.15); C639(0.47)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C639(1.08)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C645(1.17); C639(0.90); C663(1.03)  LDD1614  [6]
 LDCM0412  CL24 HEK-293T C645(1.29); C436(1.13); C910(0.91); C663(1.33)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C645(1.26)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C645(1.18); C639(1.03)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C645(1.06); C639(1.11); C436(1.05)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C645(1.29); C639(0.97)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C645(1.19); C639(0.97)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C645(1.00); C639(1.01); C436(1.00)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C645(1.02); C639(0.98); C436(1.04)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C645(1.19); C639(0.99); C187(0.96); C663(1.07)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C645(1.19); C639(0.81)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C639(1.03)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C645(1.09); C639(1.36); C663(1.01)  LDD1627  [6]
 LDCM0425  CL36 HEK-293T C645(1.29); C436(1.08); C910(1.97); C663(0.85)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C645(1.06)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C645(1.29); C639(0.98); C436(1.19)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C645(1.22); C639(0.81)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C645(1.00); C639(0.96)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C645(1.09); C639(0.90)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C645(1.05); C639(0.97); C436(0.97)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C645(1.05); C639(0.99); C187(0.98); C663(1.36)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C645(1.12); C639(0.74)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C639(1.14)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C645(1.13); C639(1.25); C663(0.82)  LDD1640  [6]
 LDCM0438  CL48 HEK-293T C645(1.05); C436(1.04); C910(1.63); C663(0.97)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C645(1.06)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C645(1.30); C639(1.00)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C645(1.18); C639(0.95)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C645(1.21); C639(0.96)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C645(1.36); C639(0.85)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C645(1.56); C639(0.90); C436(0.91)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C645(1.20); C639(0.96); C187(1.03); C663(1.11)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C645(1.25); C639(0.92)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C639(1.04)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C645(1.30); C639(0.90); C663(1.02)  LDD1652  [6]
 LDCM0451  CL6 HEK-293T C645(1.22); C639(0.93); C436(0.96)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C645(1.33); C436(1.13); C910(0.97); C663(1.19)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C645(0.94)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C645(1.13); C639(1.01)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C645(1.27); C639(0.99); C436(1.00)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C645(1.55); C639(0.90)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C645(1.24); C639(0.93)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C645(1.11); C639(0.96); C436(1.11)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C645(1.04); C639(1.09); C187(1.02); C663(0.94)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C645(1.21); C639(0.88)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C639(1.27)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C645(0.94); C639(1.04); C187(0.99); C663(1.03)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C645(1.12); C639(1.03); C663(1.09)  LDD1666  [6]
 LDCM0465  CL72 HEK-293T C645(1.06); C436(1.11); C910(1.46); C663(1.06)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C645(1.12)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C645(1.08); C639(0.99)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C645(1.28); C639(0.95)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C645(1.07); C639(1.02)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C645(1.02); C639(0.95); C436(1.10)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C645(1.17); C639(0.97); C187(0.96); C663(1.38)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C645(1.56); C639(0.73)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C645(1.12); C639(0.61)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C639(0.96)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C645(1.03); C639(1.17); C663(1.40)  LDD1679  [6]
 LDCM0478  CL84 HEK-293T C645(1.31); C436(0.91); C910(1.35); C663(0.82)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C645(0.98)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C645(1.08); C639(1.03)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C645(1.26); C639(0.97); C436(0.88)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C645(1.20); C639(1.07)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C645(0.92); C639(0.93)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C639(1.13)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C645(1.69); C639(0.90); C436(0.88)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C645(1.09); C639(1.06); C187(0.99); C663(1.20)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C645(1.14); C639(0.51)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C639(0.94)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C645(1.05); C639(1.13); C663(1.04)  LDD1692  [6]
 LDCM0491  CL96 HEK-293T C645(1.26); C436(0.80); C910(3.75); C663(1.04)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C645(1.19)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C645(1.14); C639(0.99)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C645(1.11); C639(1.03); C436(0.93)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C645(1.15); C639(0.94); C436(1.01)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C645(1.17); C639(1.06); C436(1.11)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C645(1.04); C639(1.09)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C645(0.94); C484(0.97); C639(1.08)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C645(1.03); C484(1.18); C639(1.06)  LDD1497  [6]
 LDCM0024  KB05 MEWO C649(2.41)  LDD3319  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Clobetasol Propionate Small molecular drug DB01013
Desoxycorticosterone Acetate Small molecular drug DB06780
Drospirenone Small molecular drug DB01395
Eplerenone Small molecular drug DB00700
Felodipine Small molecular drug DB01023
Fludrocortisone Small molecular drug DB00687
Fluticasone Small molecular drug DB13867
Fluticasone Furoate Small molecular drug DB08906
Fluticasone Propionate Small molecular drug DB00588
Nimodipine Small molecular drug DB00393
Progesterone Small molecular drug DB00396
Spironolactone Small molecular drug DB00421
Testosterone Small molecular drug DB00624
Finerenone . DB16165
Testosterone Cypionate . DB13943
Testosterone Enanthate . DB13944
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aldosterone Small molecular drug DB04630
Corticosterone Small molecular drug DB04652
Desoxycorticosterone Pivalate Small molecular drug DB01134
Metribolone Small molecular drug DB02998
Stanolone Acetate . DB13951
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Stanolone Small molecular drug DB02901

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402