Details of the Target

General Information of Target

Target ID LDTP02226
Target Name Galactose-1-phosphate uridylyltransferase (GALT)
Gene Name GALT
Gene ID 2592
Synonyms
Galactose-1-phosphate uridylyltransferase; Gal-1-P uridylyltransferase; EC 2.7.7.12; UDP-glucose--hexose-1-phosphate uridylyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRSGTDPQQRQQASEADAAAATFRANDHQHIRYNPLQDEWVLVSAHRMKRPWQGQVEPQ
LLKTVPRHDPLNPLCPGAIRANGEVNPQYDSTFLFDNDFPALQPDAPSPGPSDHPLFQAK
SARGVCKVMCFHPWSDVTLPLMSVPEIRAVVDAWASVTEELGAQYPWVQIFENKGAMMGC
SNPHPHCQVWASSFLPDIAQREERSQQAYKSQHGEPLLMEYSRQELLRKERLVLTSEHWL
VLVPFWATWPYQTLLLPRRHVRRLPELTPAERDDLASIMKKLLTKYDNLFETSFPYSMGW
HGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRA
LPEVHYHLGQKDRETATIA
Target Bioclass
Enzyme
Family
Galactose-1-phosphate uridylyltransferase type 1 family
Function Plays an important role in galactose metabolism.
Uniprot ID
P07902
Ensemble ID
ENST00000378842.8
HGNC ID
HGNC:4135

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P145H .
JURKAT SNV: p.L349I .
SNU1 SNV: p.Q212H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C75(0.97)  LDD3333  [1]
IPM
 Probe Info  		C75(0.66)  LDD1702  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C75(0.00); C130(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C75(0.00); C130(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C130(0.00); C75(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C75(0.90)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C75(0.92); C180(0.95)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C180(1.06)  LDD1509  [4]
 LDCM0259  AC14 HEK-293T C130(1.02); C75(1.00); C180(1.05)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C75(0.98)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C75(0.97)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C75(0.89); C180(0.98)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C180(0.83)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C75(0.98); C180(1.00)  LDD1518  [4]
 LDCM0281  AC21 HEK-293T C75(1.05); C180(0.98)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C130(1.02); C75(0.94); C180(0.96)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C75(1.03)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C75(1.08); C180(1.01)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C75(0.98)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C75(0.94); C180(0.88)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C180(1.06)  LDD1526  [4]
 LDCM0289  AC29 HEK-293T C75(1.01); C180(0.92)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C180(1.11)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C130(1.08); C75(1.03); C180(1.03)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C75(1.01)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C75(0.99); C180(1.06)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C75(1.01)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C75(0.94); C180(0.94)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C180(1.01)  LDD1535  [4]
 LDCM0298  AC37 HEK-293T C75(1.14); C180(1.01)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C130(1.10); C75(0.95); C180(1.13)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C75(1.07)  LDD1539  [4]
 LDCM0302  AC40 HEK-293T C75(0.99); C180(1.05)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C75(1.01)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C75(0.96); C180(0.96)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C180(1.12)  LDD1544  [4]
 LDCM0307  AC45 HEK-293T C75(1.16); C180(1.00)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C130(1.04); C75(1.00); C180(0.95)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C75(1.17)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C75(1.19); C180(1.08)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C75(0.96)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C75(1.14); C180(0.86)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C75(0.96); C180(0.93)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C180(0.96)  LDD1553  [4]
 LDCM0316  AC53 HEK-293T C75(1.08); C180(0.98)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C130(1.05); C75(1.02); C180(0.97)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C75(1.09)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C75(1.05); C180(1.03)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C75(0.92)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C75(1.08); C180(1.02)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C180(0.98)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C130(0.96); C75(0.97); C180(0.82)  LDD1562  [4]
 LDCM0325  AC61 HEK-293T C75(1.08); C180(0.94)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C130(0.93); C75(1.00); C180(1.01)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C75(0.93)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C75(1.07); C180(1.06)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C75(0.96)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C75(1.10); C180(1.03)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C75(1.06); C180(1.18)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C75(0.96)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C75(1.00); C180(0.98)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C75(0.91)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C130(0.93); C75(1.13); C180(0.87)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C75(1.05); C180(0.92)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C75(0.94)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C75(0.99); C180(1.13)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C75(1.00); C180(0.88)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C75(0.92)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C75(1.04); C180(0.95)  LDD1579  [4]
 LDCM0377  CL108 HEK-293T C75(1.00); C180(1.65)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C75(0.98)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C75(1.02)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C75(0.99); C180(0.94)  LDD1584  [4]
 LDCM0382  CL112 HEK-293T C75(0.95); C180(0.81)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C75(1.04)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C75(1.05); C180(1.01)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C75(1.04); C180(0.89)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C75(1.07)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C75(1.00); C180(1.12)  LDD1592  [4]
 LDCM0390  CL12 HEK-293T C75(1.05); C180(0.98)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C75(1.13); C180(0.92)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C75(1.00)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C75(1.06); C180(1.01)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C75(1.05); C180(0.81)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C75(1.07)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C75(1.01); C180(1.11)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C75(1.15); C180(0.83)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C75(1.11)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C75(1.05); C180(1.21)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C75(1.02); C180(1.07)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C75(0.96)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C75(1.03); C180(0.91)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C180(0.98)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C75(1.09); C180(1.22)  LDD1611  [4]
 LDCM0409  CL21 HEK-293T C75(1.23); C180(0.88)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C130(0.99); C75(1.12); C180(0.93)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C75(0.99)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C75(0.95); C180(1.00)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C75(1.14)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C75(0.95); C180(1.09)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C75(0.90); C180(0.79)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C75(0.89)  LDD1621  [4]
 LDCM0419  CL30 HEK-293T C75(0.91); C180(0.92)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C180(1.15)  LDD1624  [4]
 LDCM0422  CL33 HEK-293T C75(1.06); C180(1.25)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C130(0.99); C75(1.05); C180(0.92)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C75(0.89)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C75(0.99); C180(1.07)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C75(1.08)  LDD1630  [4]
 LDCM0429  CL4 HEK-293T C75(1.07); C180(0.84)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C75(0.96); C180(0.89)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C75(0.97)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C75(0.98); C180(0.83)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C180(0.95)  LDD1637  [4]
 LDCM0435  CL45 HEK-293T C75(1.07); C180(0.97)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C130(1.17); C75(1.04); C180(0.84)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C75(0.94)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C75(1.08); C180(0.93)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C75(1.09)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C75(0.99)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C75(1.02); C180(1.14)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C75(1.06); C180(1.01)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C75(1.03)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C75(0.98); C180(1.03)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C180(1.36)  LDD1649  [4]
 LDCM0448  CL57 HEK-293T C75(1.36); C180(0.90)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C130(0.99); C75(1.19); C180(0.86)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C75(1.02)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C75(0.98); C180(0.87)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C75(0.99); C180(1.06)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C75(1.02)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C75(0.98); C180(1.23)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C75(1.07); C180(0.87)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C75(0.92)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C75(1.02); C180(1.46)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C180(0.89)  LDD1662  [4]
 LDCM0461  CL69 HEK-293T C75(1.15); C180(0.92)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C180(0.99)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C130(1.10); C75(1.10); C180(0.90)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C75(1.05)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C75(0.96); C180(0.95)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C75(1.12)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C75(1.00); C180(1.04)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C75(1.11); C180(0.91)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C75(1.06)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C75(0.92); C180(1.01)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C180(0.96)  LDD1675  [4]
 LDCM0475  CL81 HEK-293T C75(1.16); C180(0.95)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C130(1.08); C75(1.11); C180(0.89)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C75(0.94)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C75(1.11); C180(0.90)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C75(1.01)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C75(1.08); C180(1.12)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C75(1.02); C180(0.89)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C75(1.06)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C75(1.38); C180(1.02)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C75(1.06); C180(1.70)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C180(1.02)  LDD1689  [4]
 LDCM0488  CL93 HEK-293T C75(1.18); C180(0.93)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C130(1.02); C75(1.05); C180(0.88)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C75(1.12)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C75(1.08); C180(0.89)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C75(1.02)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C75(0.97); C180(1.51)  LDD1696  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C75(0.66)  LDD1702  [2]
 LDCM0427  Fragment51 HEK-293T C75(1.02); C180(1.18)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C75(1.00); C180(1.10)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C75(1.05); C180(0.96)  LDD1497  [4]
 LDCM0024  KB05 MOLM-13 C75(0.97)  LDD3333  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
NAD(P)H dehydrogenase [quinone] 1 (NQO1) NAD(P)H dehydrogenase (quinone) family P15559
Activated CDC42 kinase 1 (TNK2) Tyr protein kinase family Q07912
Ubiquitin domain-containing protein 2 (UBTD2) . Q8WUN7
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GrpE protein homolog 1, mitochondrial (GRPEL1) GrpE family Q9HAV7
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402