Details of the Target

General Information of Target

Target ID LDTP01943
Target Name Fibrinogen gamma chain (FGG)
Gene Name FGG
Gene ID 2266
Synonyms
Fibrinogen gamma chain
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSWSLHPRNLILYFYALLFLSSTCVAYVATRDNCCILDERFGSYCPTTCGIADFLSTYQT
KVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIM
KYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQ
DIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEG
FGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKY
RLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGW
WMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTI
GEGQQHHLGGAKQVRPEHPAETEYDSLYPEDDL
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Secreted
Function
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
TTD ID
T26144
Uniprot ID
P02679
DrugMap ID
TTR31L7
Ensemble ID
ENST00000336098.8
HGNC ID
HGNC:3694
ChEMBL ID
CHEMBL2364709

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.Y306C .
AU565 SNV: p.D346H .
COLO792 SNV: p.D32N .
DU145 SNV: p.H243Q .
HEC1 SNV: p.R401W .
HSC4 SNV: p.Ter454YextTer5 .
IGROV1 SNV: p.Y15H .
KARPAS299 Insertion: p.D314EfsTer51 .
KMS11 SNV: p.G176E .
NUGC3 Deletion: p.P386del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C34(0.00); C49(0.00); C45(0.00); C35(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C34(1.91)  LDD0532  [2]
Acrolein
 Probe Info  		C34(0.00); C35(0.00)  LDD0217  [3]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [3]
Methacrolein
 Probe Info  		C34(0.00); C35(0.00)  LDD0218  [3]
W1
 Probe Info  		N.A.  LDD0236  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C34(1.91)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C34(0.99)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C34(1.63)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C34(1.36)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C34(2.66)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C34(0.93)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C34(0.73)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C34(1.30)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C34(1.15)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C34(0.95)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C34(0.90)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C34(0.94)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C34(1.40)  LDD0601  [2]
 LDCM0323  AC6 HCT 116 C34(0.31)  LDD0640  [2]
 LDCM0334  AC7 HCT 116 C34(0.36)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C34(0.26)  LDD0662  [2]
 LDCM0248  AKOS034007472 HCT 116 C34(1.14)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C34(2.56)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C34(2.71)  LDD0592  [2]
 LDCM0370  CL101 HCT 116 C34(0.82)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C34(2.50)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C34(0.25)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C34(1.60)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C34(1.11)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C34(0.82)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C34(1.53)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C34(0.92)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C34(0.94)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C34(1.07)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C34(0.99)  LDD0698  [2]
 LDCM0404  CL17 HCT 116 C34(1.43)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C34(2.00)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C34(1.19)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C34(2.16)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C34(0.91)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C34(2.11)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C34(0.91)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C34(1.44)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C34(0.46)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C34(0.83)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C34(1.96)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C34(0.66)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C34(2.00)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C34(0.85)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C34(1.42)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C34(1.12)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C34(1.03)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C34(1.56)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C34(1.01)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C34(0.99)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C34(0.97)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C34(0.98)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C34(0.97)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C34(1.09)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C34(0.92)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C34(1.11)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C34(1.13)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C34(1.47)  LDD0752  [2]
 LDCM0427  Fragment51 HCT 116 C34(0.90)  LDD0744  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alteplase BiotechDrug DB00009
Sucralfate Small molecular drug DB00364
Human Thrombin . DB11571
Thrombin . DB11300
Thrombin Alfa . DB11572

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264