Details of the Target

General Information of Target

Target ID LDTP01929
Target Name Alpha-crystallin B chain (CRYAB)
Gene Name CRYAB
Gene ID 1410
Synonyms
CRYA2; HSPB5; Alpha-crystallin B chain; Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSW
FDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHR
KYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
Target Bioclass
Transporter and channel
Family
Small heat shock protein (HSP20) family
Subcellular location
Cytoplasm
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome.
Uniprot ID
P02511
Ensemble ID
ENST00000227251.7
HGNC ID
HGNC:2389
ChEMBL ID
CHEMBL3621022

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-482
 Probe Info  		Y48(0.93)  LDD0286  [1]
HHS-475
 Probe Info  		Y48(0.72)  LDD0264  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y48(0.72)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y48(0.85)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y48(0.62)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y48(0.98)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y48(1.31)  LDD0268  [2]
 LDCM0124  JWB142 DM93 Y48(0.93)  LDD0286  [1]
 LDCM0125  JWB146 DM93 Y48(2.37)  LDD0287  [1]
 LDCM0126  JWB150 DM93 Y48(3.14)  LDD0288  [1]
 LDCM0128  JWB198 DM93 Y48(3.08)  LDD0290  [1]
 LDCM0130  JWB211 DM93 Y48(1.77)  LDD0292  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydropyrimidinase-related protein 1 (CRMP1) Hydantoinase/dihydropyrimidinase family Q14194
Protein prune homolog 2 (PRUNE2) PPase class C family Q8WUY3
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Alpha-crystallin B chain (CRYAB) Small heat shock protein (HSP20) family P02511
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A4 (ANXA4) Annexin family P09525
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Beta-crystallin A3 (CRYBA1) Beta/gamma-crystallin family P05813
Gamma-crystallin C (CRYGC) Beta/gamma-crystallin family P07315
Gamma-crystallin S (CRYGS) Beta/gamma-crystallin family P22914
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Heat shock protein beta-2 (HSPB2) Small heat shock protein (HSP20) family Q16082

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.