Details of the Target

General Information of Target

Target ID LDTP01826
Target Name GTPase HRas (HRAS)
Gene Name HRAS
Gene ID 3265
Synonyms
HRAS1; GTPase HRas; EC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Ras family
Subcellular location
Nucleus; Cell membrane
Function Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
TTD ID
T71081
Uniprot ID
P01112
DrugMap ID
TTHO7TF
Ensemble ID
ENST00000311189.8
HGNC ID
HGNC:5173
ChEMBL ID
CHEMBL2167

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.F82L .
HCC1419 SNV: p.R128W .
HS578T SNV: p.G12D .
KASUMI2 SNV: p.G13S .
KYSE30 SNV: p.Q61L DBIA    Probe Info 
MCC13 SNV: p.Q61R .
MCC26 SNV: p.G12D .
MELJUSO SNV: p.G13D .
MOLT4 SNV: p.R123H .
RL952 SNV: p.Q61H .
T24 SNV: p.G12V DBIA    Probe Info 
ZR751 SNV: p.E162K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.07  LDD0402  [1]
Jackson_1
 Probe Info  		20.00  LDD0122  [2]
IPM
 Probe Info  		C118(1.51)  LDD1701  [3]
DBIA
 Probe Info  		C181(0.97); C184(0.97)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C80(0.00); C51(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
AOyne
 Probe Info  		14.80  LDD0443  [6]
NAIA_5
 Probe Info  		C80(0.00); C118(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0263  AC143 HCT 116 C181(1.52); C184(1.52)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C181(0.57); C184(0.57)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C181(1.48); C184(1.48)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C181(0.88); C184(0.88)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C181(0.94); C184(0.94)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C181(1.58); C184(1.58)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C181(1.01); C184(1.01)  LDD0586  [4]
 LDCM0271  AC150 HCT 116 C181(0.85); C184(0.85)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C181(0.86); C184(0.86)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C181(0.95); C184(0.95)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C181(1.25); C184(1.25)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C181(1.31); C184(1.31)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C181(1.20); C184(1.20)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C181(1.06); C184(1.06)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C181(0.93); C184(0.93)  LDD2161  [4]
 LDCM0296  AC35 HCT 116 C181(1.09); C184(1.09)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C181(0.86); C184(0.86)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C181(1.02); C184(1.02)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C181(0.91); C184(0.91)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C181(0.99); C184(0.99)  LDD0617  [4]
 LDCM0302  AC40 HCT 116 C181(1.00); C184(1.00)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C181(1.10); C184(1.10)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C181(1.05); C184(1.05)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C181(1.10); C184(1.10)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C181(1.23); C184(1.23)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C181(1.22); C184(1.22)  LDD0624  [4]
 LDCM0349  AC83 HCT 116 C181(1.03); C184(1.03)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C181(0.84); C184(0.84)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C181(0.91); C184(0.91)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C181(1.12); C184(1.12)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C181(1.16); C184(1.16)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C181(1.25); C184(1.25)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C181(1.26); C184(1.26)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C181(1.42); C184(1.42)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C181(0.95); C184(0.95)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C181(1.10); C184(1.10)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C181(1.07); C184(1.07)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C181(0.99); C184(0.99)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C181(1.72); C184(1.72)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C181(0.87); C184(0.87)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C181(1.24); C184(1.24)  LDD0681  [4]
 LDCM0020  ARS-1620 HCC44 C181(0.97); C184(0.97)  LDD0078  [4]
 LDCM0372  CL103 HEK-293T C181(1.06)  LDD1576  [8]
 LDCM0376  CL107 HEK-293T C181(1.13)  LDD1580  [8]
 LDCM0381  CL111 HEK-293T C181(0.95)  LDD1585  [8]
 LDCM0385  CL115 HEK-293T C181(1.10)  LDD1589  [8]
 LDCM0387  CL117 HCT 116 C181(0.86); C184(0.86)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C181(0.83); C184(0.83)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C181(0.99); C184(0.99)  LDD0706  [4]
 LDCM0391  CL120 HCT 116 C181(1.12); C184(1.12)  LDD0708  [4]
 LDCM0394  CL123 HEK-293T C181(1.99)  LDD1598  [8]
 LDCM0398  CL127 HEK-293T C181(1.43)  LDD1602  [8]
 LDCM0402  CL15 HEK-293T C181(1.04)  LDD1606  [8]
 LDCM0403  CL16 HCT 116 C181(1.04); C184(1.04)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C181(0.58); C184(0.58)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C181(0.81); C184(0.81)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C181(1.02); C184(1.02)  LDD0723  [4]
 LDCM0408  CL20 HCT 116 C181(1.14); C184(1.14)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C181(0.92); C184(0.92)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C181(1.00); C184(1.00)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C181(1.30); C184(1.30)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C181(0.88); C184(0.88)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C181(1.04); C184(1.04)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C181(1.20); C184(1.20)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C181(1.02); C184(1.02)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C181(0.94); C184(0.94)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C181(1.41); C184(1.41)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C181(1.03)  LDD1622  [8]
 LDCM0419  CL30 HCT 116 C181(1.17); C184(1.17)  LDD0736  [4]
 LDCM0428  CL39 HEK-293T C181(1.05)  LDD1632  [8]
 LDCM0453  CL61 HCT 116 C181(0.74); C184(0.74)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C181(1.12); C184(1.12)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C181(0.75); C184(0.75)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C181(0.76); C184(0.76)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C181(0.78); C184(0.78)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C181(0.88); C184(0.88)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C181(0.70); C184(0.70)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C181(0.95); C184(0.95)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C181(0.74); C184(0.74)  LDD0778  [4]
 LDCM0463  CL70 HCT 116 C181(0.72); C184(0.72)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C181(0.90); C184(0.90)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C181(0.68); C184(0.68)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C181(0.75); C184(0.75)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C181(0.86); C184(0.86)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C181(1.02); C184(1.02)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C181(0.84); C184(0.84)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C181(1.06); C184(1.06)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C181(1.04); C184(1.04)  LDD0789  [4]
 LDCM0474  CL80 HCT 116 C181(0.91); C184(0.91)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C181(0.87); C184(0.87)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C181(0.98); C184(0.98)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C181(0.96); C184(0.96)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C181(0.88); C184(0.88)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C181(1.01); C184(1.01)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C181(0.98); C184(0.98)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C181(0.84); C184(0.84)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C181(0.89); C184(0.89)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C181(1.04); C184(1.04)  LDD0800  [4]
 LDCM0485  CL90 HCT 116 C181(0.79); C184(0.79)  LDD0802  [4]
 LDCM0494  CL99 HEK-293T C181(1.23)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C181(1.05)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C181(0.73); C184(0.73)  LDD0785  [4]
 LDCM0022  KB02 HEK-293T C51(0.89); C181(0.85)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C51(0.90); C181(1.05)  LDD1497  [8]
 LDCM0024  KB05 MIA PaCa-2 C118(1.08)  LDD3330  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
60 kDa heat shock protein, mitochondrial (HSPD1) Chaperonin (HSP60) family P10809
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Dihydropyrimidinase (DPYS) Hydantoinase/dihydropyrimidinase family Q14117
Transcriptional adapter 3 (TADA3) NGG1 family O75528
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) PI3/PI4-kinase family O00329
Cyclin-dependent kinase 2 (CDK2) CMGC Ser/Thr protein kinase family P24941
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) STE Ser/Thr protein kinase family Q99558
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
Serine/threonine-protein kinase B-raf (BRAF) TKL Ser/Thr protein kinase family P15056
Dual specificity protein phosphatase 10 (DUSP10) Protein-tyrosine phosphatase family Q9Y6W6
N-acetylaspartylglutamate synthase A (RIMKLA) RimK family Q8IXN7
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) Short-chain dehydrogenases/reductases (SDR) family Q53GQ0
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Ras-related protein Ral-A (RALA) Ras family P11233
Acyl-coenzyme A thioesterase THEM4 (THEM4) THEM4/THEM5 thioesterase family Q5T1C6
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
BRCA1-associated protein (BRAP) . Q7Z569
E3 ubiquitin-protein ligase RNF138 (RNF138) . Q8WVD3
Inactive phospholipase C-like protein 2 (PLCL2) . Q9UPR0
pre-mRNA splicing regulator USH1G (USH1G) . Q495M9
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Kelch-like protein 3 (KLHL3) . Q9UH77
Stromal interaction molecule 1 (STIM1) . Q13586
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C11 (HOXC11) Abd-B homeobox family O43248
Fos-related antigen 1 (FOSL1) BZIP family P15407
Fos-related antigen 2 (FOSL2) BZIP family P15408
Transcription factor E2F8 (E2F8) E2F/DP family A0AVK6
Krueppel-like factor 3 (KLF3) Krueppel C2H2-type zinc-finger protein family P57682
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 436 (ZNF436) Krueppel C2H2-type zinc-finger protein family Q9C0F3
Golgin-45 (BLZF1) . Q9H2G9
Upstream stimulatory factor 1 (USF1) . P22415
Other
Click To Hide/Show 50 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aurora kinase A- and ninein-interacting protein (AUNIP) AUNIP family Q9H7T9
Protein BEX3 (BEX3) BEX family Q00994
Breast cancer metastasis-suppressor 1-like protein (BRMS1L) BRMS1 family Q5PSV4
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5
Segment polarity protein dishevelled homolog DVL-2 (DVL2) DSH family O14641
Protein FAM184A (FAM184A) FAM184 family Q8NB25
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
HAUS augmin-like complex subunit 8 (HAUS8) HAUS8 family Q9BT25
Protein HID1 (HID1) Hid-1 family Q8IV36
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Centrosomal protein kizuna (KIZ) Kizuna family Q2M2Z5
Protein Mis18-beta (OIP5) Mis18 family O43482
Meiosis-specific nuclear structural protein 1 (MNS1) MNS1 family Q8NEH6
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
PHD finger protein 23 (PHF23) PHF23 family Q9BUL5
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) SNF5 family Q12824
Charged multivesicular body protein 7 (CHMP7) SNF7 family Q8WUX9
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Transcription initiation factor IIA subunit 1 (GTF2A1) TFIIA subunit 1 family P52655
Translin-associated protein X (TSNAX) Translin family Q99598
Centrosomal protein of 57 kDa (CEP57) Translokin family Q86XR8
Vacuolar protein sorting-associated protein 11 homolog (VPS11) VPS11 family Q9H270
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
Centromere protein R (ITGB3BP) . Q13352
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Ephexin-1 (NGEF) . Q8N5V2
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Leucine rich adaptor protein 1 (LURAP1) . Q96LR2
Microspherule protein 1 (MCRS1) . Q96EZ8
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Neurofibromin (NF1) . P21359
Outer dynein arm-docking complex subunit 3 (ODAD3) . A5D8V7
Period circadian protein homolog 1 (PER1) . O15534
Probable RNA-binding protein 46 (RBM46) . Q8TBY0
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Ral guanine nucleotide dissociation stimulator (RALGDS) . Q12967
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1) . Q9NZL6
Ras association domain-containing protein 5 (RASSF5) . Q8WWW0
Son of sevenless homolog 1 (SOS1) . Q07889
Splicing factor 3B subunit 2 (SF3B2) . Q13435
Testis-expressed protein 12 (TEX12) . Q9BXU0
Tetratricopeptide repeat protein 23-like (TTC23L) . Q6PF05
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 13920 Antisense drug D0O8BP
Isis 2502 Antisense drug D07WCX
Isis 6186 Antisense drug D05VBN
Guanosine-5'-diphosphate Small molecular drug DB04315
Guanosine-5'-triphosphate Small molecular drug DB04137
Hexane-16-diol Small molecular drug DB02210
Trifluoroethanol Small molecular drug DB03226
Ursolic Acid Small molecular drug DB15588
Nn'-dimethyl-n-(Acetyl)-n'-(7-nitrobenz-2-oxa-13-diazol-4-yl)Ethylenediamine . DB08751
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 2503 Antisense drug D01XDN

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840