Details of the Target

General Information of Target

Target ID LDTP01646
Target Name V-type proton ATPase subunit G 2 (ATP6V1G2)
Gene Name ATP6V1G2
Gene ID 534
Synonyms
ATP6G; ATP6G2; NG38; V-type proton ATPase subunit G 2; V-ATPase subunit G 2; V-ATPase 13 kDa subunit 2; Vacuolar proton pump subunit G 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASQSQGIQQLLQAEKRAAEKVADARKRKARRLKQAKEEAQMEVEQYRREREHEFQSKQQ
AAMGSQGNLSAEVEQATRRQVQGMQSSQQRNRERVLAQLLGMVCDVRPQVHPNYRISA
Target Bioclass
Enzyme
Family
V-ATPase G subunit family
Subcellular location
Melanosome
Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Uniprot ID
O95670
Ensemble ID
ENST00000303892.10
HGNC ID
HGNC:862

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.Q109H .
TKKK SNV: p.R92Q .
TOV21G SNV: p.E72Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K16(5.26)  LDD0274  [1]
DBIA
 Probe Info  		C104(1.03)  LDD1508  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C104(1.03)  LDD1508  [2]
 LDCM0237  AC12 HEK-293T C104(1.06)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C104(1.03)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C104(0.85)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C104(0.92)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C104(1.02)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C104(1.06)  LDD1519  [2]
 LDCM0282  AC22 HEK-293T C104(1.07)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C104(0.91)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C104(1.09)  LDD1523  [2]
 LDCM0286  AC26 HEK-293T C104(1.05)  LDD1525  [2]
 LDCM0288  AC28 HEK-293T C104(0.94)  LDD1527  [2]
 LDCM0291  AC30 HEK-293T C104(1.06)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C104(1.00)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C104(1.25)  LDD1532  [2]
 LDCM0295  AC34 HEK-293T C104(0.98)  LDD1534  [2]
 LDCM0297  AC36 HEK-293T C104(0.91)  LDD1536  [2]
 LDCM0299  AC38 HEK-293T C104(1.11)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C104(0.91)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C104(0.98)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C104(1.01)  LDD1541  [2]
 LDCM0304  AC42 HEK-293T C104(1.00)  LDD1543  [2]
 LDCM0306  AC44 HEK-293T C104(0.98)  LDD1545  [2]
 LDCM0308  AC46 HEK-293T C104(1.00)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C104(0.92)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C104(1.20)  LDD1549  [2]
 LDCM0313  AC50 HEK-293T C104(1.05)  LDD1552  [2]
 LDCM0315  AC52 HEK-293T C104(1.09)  LDD1554  [2]
 LDCM0317  AC54 HEK-293T C104(1.10)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C104(0.93)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C104(1.04)  LDD1558  [2]
 LDCM0321  AC58 HEK-293T C104(0.99)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C104(1.04)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C104(0.98)  LDD1563  [2]
 LDCM0326  AC62 HEK-293T C104(1.15)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C104(0.92)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C104(1.14)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C104(0.92)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C104(1.11)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C104(1.13)  LDD1514  [2]
 LDCM0368  CL10 HEK-293T C104(1.05)  LDD1572  [2]
 LDCM0379  CL11 HEK-293T C104(0.90)  LDD1583  [2]
 LDCM0390  CL12 HEK-293T C104(1.00)  LDD1594  [2]
 LDCM0405  CL18 HEK-293T C104(0.92)  LDD1609  [2]
 LDCM0408  CL20 HEK-293T C104(1.13)  LDD1612  [2]
 LDCM0410  CL22 HEK-293T C104(1.20)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C104(0.90)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C104(1.07)  LDD1616  [2]
 LDCM0419  CL30 HEK-293T C104(1.02)  LDD1623  [2]
 LDCM0421  CL32 HEK-293T C104(1.00)  LDD1625  [2]
 LDCM0423  CL34 HEK-293T C104(1.08)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C104(0.83)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C104(1.16)  LDD1629  [2]
 LDCM0432  CL42 HEK-293T C104(1.04)  LDD1636  [2]
 LDCM0434  CL44 HEK-293T C104(0.96)  LDD1638  [2]
 LDCM0436  CL46 HEK-293T C104(1.24)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C104(0.77)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C104(1.04)  LDD1642  [2]
 LDCM0445  CL54 HEK-293T C104(0.88)  LDD1648  [2]
 LDCM0447  CL56 HEK-293T C104(1.06)  LDD1650  [2]
 LDCM0449  CL58 HEK-293T C104(1.08)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C104(0.91)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C104(0.86)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C104(1.06)  LDD1655  [2]
 LDCM0458  CL66 HEK-293T C104(0.94)  LDD1661  [2]
 LDCM0460  CL68 HEK-293T C104(0.96)  LDD1663  [2]
 LDCM0463  CL70 HEK-293T C104(1.07)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C104(0.85)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C104(1.12)  LDD1668  [2]
 LDCM0471  CL78 HEK-293T C104(0.96)  LDD1674  [2]
 LDCM0473  CL8 HEK-293T C104(0.66)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C104(1.15)  LDD1677  [2]
 LDCM0476  CL82 HEK-293T C104(0.95)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C104(0.99)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C104(1.11)  LDD1681  [2]
 LDCM0485  CL90 HEK-293T C104(0.36)  LDD1688  [2]
 LDCM0487  CL92 HEK-293T C104(1.08)  LDD1690  [2]
 LDCM0489  CL94 HEK-293T C104(1.00)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C104(0.78)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C104(1.12)  LDD1694  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402