Details of the Target

General Information of Target

Target ID LDTP01339
Target Name Signal transducing adapter molecule 2 (STAM2)
Gene Name STAM2
Gene ID 10254
Synonyms
HBP; Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPH
VALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEF
QKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQE
QKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWW
KGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRA
LQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALEL
YNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSL
GPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQ
MGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL
Target Bioclass
Other
Family
STAM family
Subcellular location
Cytoplasm
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Uniprot ID
O75886
Ensemble ID
ENST00000263904.5
HGNC ID
HGNC:11358

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L420P .
CCK81 SNV: p.Y371C .
HGC27 SNV: p.L69F DBIA    Probe Info 
HT115 SNV: p.K284T .
JHH1 SNV: p.S194T DBIA    Probe Info 
MDAMB453 SNV: p.Q424E .
MELJUSO SNV: p.Q521H DBIA    Probe Info 
SKMEL30 SNV: p.V256I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Probe 1
 Probe Info  		Y211(10.15); Y291(9.34); Y371(11.59)  LDD3495  [2]
DBIA
 Probe Info  		C85(4.03)  LDD3312  [3]
BTD
 Probe Info  		C85(1.24)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C85(2.10)  LDD0170  [5]
HHS-475
 Probe Info  		Y374(1.02); Y371(2.22)  LDD0264  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
W1
 Probe Info  		N.A.  LDD0236  [1]
AOyne
 Probe Info  		13.40  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
HHS-482
 Probe Info  		Y371(1.16)  LDD2239  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C85(0.68)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C85(1.04)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C85(1.12)  LDD2152  [4]
 LDCM0025  4SU-RNA DM93 C85(2.10)  LDD0170  [5]
 LDCM0214  AC1 PaTu 8988t C72(0.59); C76(0.59)  LDD1093  [13]
 LDCM0215  AC10 HEK-293T C76(0.98)  LDD1508  [14]
 LDCM0230  AC113 PaTu 8988t C72(1.07); C76(1.07)  LDD1109  [13]
 LDCM0231  AC114 PaTu 8988t C72(0.88); C76(0.88)  LDD1110  [13]
 LDCM0232  AC115 PaTu 8988t C72(1.01); C76(1.01)  LDD1111  [13]
 LDCM0233  AC116 PaTu 8988t C72(1.01); C76(1.01)  LDD1112  [13]
 LDCM0234  AC117 PaTu 8988t C72(0.95); C76(0.95)  LDD1113  [13]
 LDCM0235  AC118 PaTu 8988t C72(1.17); C76(1.17)  LDD1114  [13]
 LDCM0236  AC119 PaTu 8988t C72(1.02); C76(1.02)  LDD1115  [13]
 LDCM0238  AC120 PaTu 8988t C72(1.02); C76(1.02)  LDD1117  [13]
 LDCM0239  AC121 PaTu 8988t C72(0.91); C76(0.91)  LDD1118  [13]
 LDCM0240  AC122 PaTu 8988t C72(1.04); C76(1.04)  LDD1119  [13]
 LDCM0241  AC123 PaTu 8988t C72(0.94); C76(0.94)  LDD1120  [13]
 LDCM0242  AC124 PaTu 8988t C72(0.92); C76(0.92)  LDD1121  [13]
 LDCM0243  AC125 PaTu 8988t C72(1.24); C76(1.24)  LDD1122  [13]
 LDCM0244  AC126 PaTu 8988t C72(1.05); C76(1.05)  LDD1123  [13]
 LDCM0245  AC127 PaTu 8988t C72(0.96); C76(0.96)  LDD1124  [13]
 LDCM0270  AC15 HEK-293T C76(1.10)  LDD1513  [14]
 LDCM0276  AC17 PaTu 8988t C72(0.94); C76(0.94)  LDD1155  [13]
 LDCM0277  AC18 PaTu 8988t C72(0.65); C76(0.65)  LDD1156  [13]
 LDCM0278  AC19 PaTu 8988t C72(0.75); C76(0.75)  LDD1157  [13]
 LDCM0279  AC2 PaTu 8988t C72(0.64); C76(0.64)  LDD1158  [13]
 LDCM0280  AC20 PaTu 8988t C72(0.84); C76(0.84)  LDD1159  [13]
 LDCM0281  AC21 PaTu 8988t C72(0.66); C76(0.66)  LDD1160  [13]
 LDCM0282  AC22 PaTu 8988t C72(0.76); C76(0.76)  LDD1161  [13]
 LDCM0283  AC23 PaTu 8988t C72(0.76); C76(0.76)  LDD1162  [13]
 LDCM0284  AC24 PaTu 8988t C72(0.80); C76(0.80)  LDD1163  [13]
 LDCM0285  AC25 PaTu 8988t C72(1.28); C76(1.28)  LDD1164  [13]
 LDCM0286  AC26 PaTu 8988t C72(1.01); C76(1.01)  LDD1165  [13]
 LDCM0287  AC27 PaTu 8988t C72(0.95); C76(0.95)  LDD1166  [13]
 LDCM0288  AC28 PaTu 8988t C72(1.21); C76(1.21)  LDD1167  [13]
 LDCM0289  AC29 PaTu 8988t C72(1.08); C76(1.08)  LDD1168  [13]
 LDCM0290  AC3 PaTu 8988t C72(0.57); C76(0.57)  LDD1169  [13]
 LDCM0291  AC30 PaTu 8988t C72(1.23); C76(1.23)  LDD1170  [13]
 LDCM0292  AC31 PaTu 8988t C72(1.08); C76(1.08)  LDD1171  [13]
 LDCM0293  AC32 PaTu 8988t C72(0.94); C76(0.94)  LDD1172  [13]
 LDCM0294  AC33 PaTu 8988t C72(1.04); C76(1.04)  LDD1173  [13]
 LDCM0295  AC34 PaTu 8988t C72(1.09); C76(1.09)  LDD1174  [13]
 LDCM0296  AC35 PaTu 8988t C72(0.81); C76(0.81)  LDD1175  [13]
 LDCM0297  AC36 PaTu 8988t C72(0.74); C76(0.74)  LDD1176  [13]
 LDCM0298  AC37 PaTu 8988t C72(0.64); C76(0.64)  LDD1177  [13]
 LDCM0299  AC38 PaTu 8988t C72(0.69); C76(0.69)  LDD1178  [13]
 LDCM0300  AC39 PaTu 8988t C72(0.65); C76(0.65)  LDD1179  [13]
 LDCM0301  AC4 PaTu 8988t C72(0.68); C76(0.68)  LDD1180  [13]
 LDCM0302  AC40 PaTu 8988t C72(0.58); C76(0.58)  LDD1181  [13]
 LDCM0303  AC41 PaTu 8988t C72(0.68); C76(0.68)  LDD1182  [13]
 LDCM0304  AC42 PaTu 8988t C72(0.61); C76(0.61)  LDD1183  [13]
 LDCM0305  AC43 PaTu 8988t C72(0.67); C76(0.67)  LDD1184  [13]
 LDCM0306  AC44 PaTu 8988t C72(0.61); C76(0.61)  LDD1185  [13]
 LDCM0307  AC45 PaTu 8988t C72(0.66); C76(0.66)  LDD1186  [13]
 LDCM0309  AC47 HEK-293T C76(1.12)  LDD1548  [14]
 LDCM0312  AC5 PaTu 8988t C72(0.73); C76(0.73)  LDD1191  [13]
 LDCM0313  AC50 HEK-293T C76(1.03)  LDD1552  [14]
 LDCM0316  AC53 HEK-293T C72(0.84)  LDD1555  [14]
 LDCM0318  AC55 HEK-293T C76(1.11)  LDD1557  [14]
 LDCM0320  AC57 PaTu 8988t C72(0.95); C76(0.95)  LDD1199  [13]
 LDCM0321  AC58 PaTu 8988t C72(1.07); C76(1.07)  LDD1200  [13]
 LDCM0322  AC59 PaTu 8988t C72(1.21); C76(1.21)  LDD1201  [13]
 LDCM0324  AC60 PaTu 8988t C72(1.10); C76(1.10)  LDD1203  [13]
 LDCM0325  AC61 PaTu 8988t C72(0.99); C76(0.99)  LDD1204  [13]
 LDCM0326  AC62 PaTu 8988t C72(0.98); C76(0.98)  LDD1205  [13]
 LDCM0327  AC63 PaTu 8988t C72(1.08); C76(1.08)  LDD1206  [13]
 LDCM0328  AC64 PaTu 8988t C72(1.03); C76(1.03)  LDD1207  [13]
 LDCM0329  AC65 PaTu 8988t C72(1.14); C76(1.14)  LDD1208  [13]
 LDCM0330  AC66 PaTu 8988t C72(1.29); C76(1.29)  LDD1209  [13]
 LDCM0331  AC67 PaTu 8988t C72(1.14); C76(1.14)  LDD1210  [13]
 LDCM0332  AC68 PaTu 8988t C72(0.81); C76(0.81)  LDD1211  [13]
 LDCM0333  AC69 PaTu 8988t C72(0.79); C76(0.79)  LDD1212  [13]
 LDCM0334  AC7 HEK-293T C76(1.23)  LDD1568  [14]
 LDCM0335  AC70 PaTu 8988t C72(0.93); C76(0.93)  LDD1214  [13]
 LDCM0336  AC71 PaTu 8988t C72(0.85); C76(0.85)  LDD1215  [13]
 LDCM0337  AC72 PaTu 8988t C72(0.83); C76(0.83)  LDD1216  [13]
 LDCM0338  AC73 PaTu 8988t C72(0.96); C76(0.96)  LDD1217  [13]
 LDCM0339  AC74 PaTu 8988t C72(0.90); C76(0.90)  LDD1218  [13]
 LDCM0340  AC75 PaTu 8988t C72(1.12); C76(1.12)  LDD1219  [13]
 LDCM0341  AC76 PaTu 8988t C72(0.77); C76(0.77)  LDD1220  [13]
 LDCM0342  AC77 PaTu 8988t C72(0.76); C76(0.76)  LDD1221  [13]
 LDCM0343  AC78 PaTu 8988t C72(0.80); C76(0.80)  LDD1222  [13]
 LDCM0344  AC79 PaTu 8988t C72(0.97); C76(0.97)  LDD1223  [13]
 LDCM0346  AC80 PaTu 8988t C72(0.84); C76(0.84)  LDD1225  [13]
 LDCM0347  AC81 PaTu 8988t C72(1.03); C76(1.03)  LDD1226  [13]
 LDCM0348  AC82 PaTu 8988t C72(0.72); C76(0.72)  LDD1227  [13]
 LDCM0520  AKOS000195272 MDA-MB-231 C85(0.74)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C72(0.99)  LDD1511  [14]
 LDCM0108  Chloroacetamide HeLa C85(0.00); H344(0.00)  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C85(0.66)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C76(0.83)  LDD1571  [14]
 LDCM0369  CL100 PaTu 8988t C72(0.71); C76(0.71)  LDD1248  [13]
 LDCM0370  CL101 HEK-293T C76(0.88)  LDD1574  [14]
 LDCM0372  CL103 HEK-293T C76(1.00)  LDD1576  [14]
 LDCM0374  CL105 PaTu 8988t C72(0.86); C76(0.86)  LDD1253  [13]
 LDCM0375  CL106 PaTu 8988t C72(0.61); C76(0.61)  LDD1254  [13]
 LDCM0376  CL107 PaTu 8988t C72(0.73); C76(0.73)  LDD1255  [13]
 LDCM0377  CL108 PaTu 8988t C72(1.01); C76(1.01)  LDD1256  [13]
 LDCM0378  CL109 PaTu 8988t C72(0.74); C76(0.74)  LDD1257  [13]
 LDCM0379  CL11 HEK-293T C76(1.07)  LDD1583  [14]
 LDCM0380  CL110 PaTu 8988t C72(0.69); C76(0.69)  LDD1259  [13]
 LDCM0381  CL111 PaTu 8988t C72(0.74); C76(0.74)  LDD1260  [13]
 LDCM0382  CL112 PaTu 8988t C72(0.98); C76(0.98)  LDD1261  [13]
 LDCM0383  CL113 PaTu 8988t C72(1.16); C76(1.16)  LDD1262  [13]
 LDCM0384  CL114 PaTu 8988t C72(1.08); C76(1.08)  LDD1263  [13]
 LDCM0385  CL115 PaTu 8988t C72(1.20); C76(1.20)  LDD1264  [13]
 LDCM0386  CL116 PaTu 8988t C72(1.35); C76(1.35)  LDD1265  [13]
 LDCM0387  CL117 PaTu 8988t C72(0.78); C76(0.78)  LDD1266  [13]
 LDCM0388  CL118 PaTu 8988t C72(0.71); C76(0.71)  LDD1267  [13]
 LDCM0389  CL119 PaTu 8988t C72(0.64); C76(0.64)  LDD1268  [13]
 LDCM0391  CL120 PaTu 8988t C72(0.71); C76(0.71)  LDD1270  [13]
 LDCM0392  CL121 HEK-293T C76(0.98)  LDD1596  [14]
 LDCM0394  CL123 HEK-293T C76(1.08)  LDD1598  [14]
 LDCM0396  CL125 PaTu 8988t C72(1.08); C76(1.08)  LDD1275  [13]
 LDCM0397  CL126 PaTu 8988t C72(1.28); C76(1.28)  LDD1276  [13]
 LDCM0398  CL127 PaTu 8988t C72(1.12); C76(1.12)  LDD1277  [13]
 LDCM0399  CL128 PaTu 8988t C72(0.90); C76(0.90)  LDD1278  [13]
 LDCM0400  CL13 HEK-293T C76(0.98)  LDD1604  [14]
 LDCM0402  CL15 HEK-293T C76(0.97)  LDD1606  [14]
 LDCM0405  CL18 HEK-293T C76(0.96)  LDD1609  [14]
 LDCM0409  CL21 HEK-293T C72(0.98)  LDD1613  [14]
 LDCM0411  CL23 HEK-293T C76(1.19)  LDD1615  [14]
 LDCM0413  CL25 HEK-293T C76(0.85)  LDD1617  [14]
 LDCM0415  CL27 HEK-293T C76(1.01)  LDD1619  [14]
 LDCM0418  CL3 HEK-293T C76(0.89)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C76(1.33)  LDD1623  [14]
 LDCM0420  CL31 PaTu 8988t C72(0.69); C76(0.69)  LDD1299  [13]
 LDCM0421  CL32 PaTu 8988t C72(0.72); C76(0.72)  LDD1300  [13]
 LDCM0422  CL33 PaTu 8988t C72(0.68); C76(0.68)  LDD1301  [13]
 LDCM0423  CL34 PaTu 8988t C72(0.78); C76(0.78)  LDD1302  [13]
 LDCM0424  CL35 PaTu 8988t C72(0.71); C76(0.71)  LDD1303  [13]
 LDCM0425  CL36 PaTu 8988t C72(0.72); C76(0.72)  LDD1304  [13]
 LDCM0426  CL37 PaTu 8988t C72(0.79); C76(0.79)  LDD1305  [13]
 LDCM0428  CL39 PaTu 8988t C72(0.67); C76(0.67)  LDD1307  [13]
 LDCM0430  CL40 PaTu 8988t C72(0.70); C76(0.70)  LDD1309  [13]
 LDCM0431  CL41 PaTu 8988t C72(0.68); C76(0.68)  LDD1310  [13]
 LDCM0432  CL42 PaTu 8988t C72(0.66); C76(0.66)  LDD1311  [13]
 LDCM0433  CL43 PaTu 8988t C72(0.79); C76(0.79)  LDD1312  [13]
 LDCM0434  CL44 PaTu 8988t C72(0.65); C76(0.65)  LDD1313  [13]
 LDCM0435  CL45 PaTu 8988t C72(0.29); C76(0.29)  LDD1314  [13]
 LDCM0437  CL47 HEK-293T C76(1.19)  LDD1641  [14]
 LDCM0439  CL49 HEK-293T C76(0.91)  LDD1643  [14]
 LDCM0445  CL54 HEK-293T C76(0.84)  LDD1648  [14]
 LDCM0448  CL57 HEK-293T C72(0.29)  LDD1651  [14]
 LDCM0450  CL59 HEK-293T C76(1.19)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C76(0.98)  LDD1654  [14]
 LDCM0453  CL61 PaTu 8988t C72(0.81); C76(0.81)  LDD1332  [13]
 LDCM0454  CL62 PaTu 8988t C72(1.21); C76(1.21)  LDD1333  [13]
 LDCM0455  CL63 PaTu 8988t C72(1.02); C76(1.02)  LDD1334  [13]
 LDCM0456  CL64 PaTu 8988t C72(0.97); C76(0.97)  LDD1335  [13]
 LDCM0457  CL65 PaTu 8988t C72(0.91); C76(0.91)  LDD1336  [13]
 LDCM0458  CL66 PaTu 8988t C72(1.04); C76(1.04)  LDD1337  [13]
 LDCM0459  CL67 PaTu 8988t C72(0.85); C76(0.85)  LDD1338  [13]
 LDCM0460  CL68 PaTu 8988t C72(0.89); C76(0.89)  LDD1339  [13]
 LDCM0461  CL69 PaTu 8988t C72(0.86); C76(0.86)  LDD1340  [13]
 LDCM0463  CL70 PaTu 8988t C72(0.76); C76(0.76)  LDD1342  [13]
 LDCM0464  CL71 PaTu 8988t C72(0.88); C76(0.88)  LDD1343  [13]
 LDCM0465  CL72 PaTu 8988t C72(1.13); C76(1.13)  LDD1344  [13]
 LDCM0466  CL73 PaTu 8988t C72(0.84); C76(0.84)  LDD1345  [13]
 LDCM0467  CL74 PaTu 8988t C72(0.85); C76(0.85)  LDD1346  [13]
 LDCM0471  CL78 HEK-293T C76(1.04)  LDD1674  [14]
 LDCM0475  CL81 HEK-293T C72(1.03)  LDD1678  [14]
 LDCM0477  CL83 HEK-293T C76(1.11)  LDD1680  [14]
 LDCM0479  CL85 HEK-293T C76(1.05)  LDD1682  [14]
 LDCM0481  CL87 HEK-293T C76(1.14)  LDD1684  [14]
 LDCM0484  CL9 HEK-293T C72(1.15)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C76(0.94)  LDD1688  [14]
 LDCM0486  CL91 PaTu 8988t C72(0.55); C76(0.55)  LDD1365  [13]
 LDCM0487  CL92 PaTu 8988t C72(0.61); C76(0.61)  LDD1366  [13]
 LDCM0488  CL93 PaTu 8988t C72(0.58); C76(0.58)  LDD1367  [13]
 LDCM0489  CL94 PaTu 8988t C72(0.69); C76(0.69)  LDD1368  [13]
 LDCM0490  CL95 PaTu 8988t C72(0.75); C76(0.75)  LDD1369  [13]
 LDCM0491  CL96 PaTu 8988t C72(0.64); C76(0.64)  LDD1370  [13]
 LDCM0492  CL97 PaTu 8988t C72(0.67); C76(0.67)  LDD1371  [13]
 LDCM0493  CL98 PaTu 8988t C72(0.68); C76(0.68)  LDD1372  [13]
 LDCM0494  CL99 PaTu 8988t C72(0.62); C76(0.62)  LDD1373  [13]
 LDCM0495  E2913 HEK-293T C76(1.06)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C85(2.89)  LDD1702  [4]
 LDCM0625  F8 Ramos C85(0.97)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C85(1.99)  LDD2190  [15]
 LDCM0468  Fragment33 PaTu 8988t C72(0.85); C76(0.85)  LDD1347  [13]
 LDCM0566  Fragment4 Ramos C85(0.67)  LDD2184  [15]
 LDCM0427  Fragment51 PaTu 8988t C72(0.66); C76(0.66)  LDD1306  [13]
 LDCM0569  Fragment7 Ramos C85(0.69)  LDD2186  [15]
 LDCM0116  HHS-0101 DM93 Y374(1.02); Y371(2.22)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y374(0.66)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y371(0.30); Y374(0.91)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y371(0.42); Y374(0.42)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y374(0.77)  LDD0268  [6]
 LDCM0107  IAA HeLa C85(0.00); H344(0.00)  LDD0221  [9]
 LDCM0022  KB02 Ramos C85(0.45)  LDD2182  [15]
 LDCM0023  KB03 MDA-MB-231 C85(5.00)  LDD1701  [4]
 LDCM0024  KB05 HMCB C85(4.03)  LDD3312  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C85(1.43)  LDD2102  [4]
 LDCM0109  NEM HeLa H81(0.00); H344(0.00)  LDD0223  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C85(1.38)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C85(1.21)  LDD2093  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C85(1.22)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C85(0.69)  LDD2100  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C85(0.62)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C85(0.65)  LDD2109  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C85(0.58)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C85(1.27)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C85(1.02)  LDD2120  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C85(0.92)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C85(1.14)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C85(0.65)  LDD2134  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C85(1.24)  LDD1700  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C85(0.92)  LDD2143  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C85(1.31)  LDD2147  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
STAM-binding protein (STAMBP) Peptidase M67C family O95630
Cell division cycle 7-related protein kinase (CDC7) Ser/Thr protein kinase family O00311
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Huntingtin (HTT) Huntingtin family P42858
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Alpha-synuclein (SNCA) Synuclein family P37840
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
Ataxin-1 (ATXN1) ATXN1 family P54253
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Prelamin-A/C (LMNA) Intermediate filament family P02545
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) Small Tim family O60220
T-complex protein 1 subunit epsilon (CCT5) TCP-1 chaperonin family P48643
Polyubiquitin-B (UBB) Ubiquitin family P0CG47
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
DAZ-associated protein 2 (DAZAP2) . Q15038
Kelch-like protein 42 (KLHL42) . Q9P2K6
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
Lymphocyte cytosolic protein 2 (LCP2) . Q13094
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
RING finger protein 11 (RNF11) . Q9Y3C5
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9
Zinc finger CCCH domain-containing protein 10 (ZC3H10) . Q96K80

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578