Details of the Target

General Information of Target

Target ID LDTP01193
Target Name Protein tyrosine phosphatase type IVA 3 (PTP4A3)
Gene Name PTP4A3
Gene ID 11156
Synonyms
PRL3; Protein tyrosine phosphatase type IVA 3; EC 3.1.3.48; PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEK
DGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI
ESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family
Subcellular location
Cell membrane
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
TTD ID
T78019
Uniprot ID
O75365
DrugMap ID
TT7YM8D
Ensemble ID
ENST00000329397.6
HGNC ID
HGNC:9636
ChEMBL ID
CHEMBL4162

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.P76RfsTer5 .
HCT15 SNV: p.V65I .
HT SNV: p.L158P .
HT115 SNV: p.D36G .
NCIH1155 SNV: p.R47P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C49(0.88)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C49(0.88)  LDD1507  [1]
 LDCM0237  AC12 HEK-293T C49(1.05)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C49(0.97)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C49(1.01)  LDD1515  [1]
 LDCM0280  AC20 HEK-293T C49(0.97)  LDD1519  [1]
 LDCM0283  AC23 HEK-293T C49(0.97)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C49(1.06)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C49(0.97)  LDD1524  [1]
 LDCM0288  AC28 HEK-293T C49(1.00)  LDD1527  [1]
 LDCM0292  AC31 HEK-293T C49(0.94)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C49(0.87)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C49(0.92)  LDD1533  [1]
 LDCM0297  AC36 HEK-293T C49(0.97)  LDD1536  [1]
 LDCM0300  AC39 HEK-293T C49(1.01)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C49(0.91)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C49(0.96)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C49(1.01)  LDD1542  [1]
 LDCM0306  AC44 HEK-293T C49(1.05)  LDD1545  [1]
 LDCM0309  AC47 HEK-293T C49(0.99)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C49(1.04)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C49(0.99)  LDD1550  [1]
 LDCM0315  AC52 HEK-293T C49(1.01)  LDD1554  [1]
 LDCM0318  AC55 HEK-293T C49(0.97)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C49(0.96)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C49(1.03)  LDD1559  [1]
 LDCM0324  AC60 HEK-293T C49(0.99)  LDD1563  [1]
 LDCM0327  AC63 HEK-293T C49(0.99)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C49(0.89)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C49(0.96)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C49(0.96)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C49(0.96)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C49(0.93)  LDD1514  [1]
 LDCM0369  CL100 HEK-293T C49(0.94)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C49(0.92)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C49(0.97)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C49(1.10)  LDD1583  [1]
 LDCM0382  CL112 HEK-293T C49(1.00)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C49(0.88)  LDD1590  [1]
 LDCM0390  CL12 HEK-293T C49(1.04)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C49(1.08)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C49(1.00)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C49(1.02)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C49(0.87)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C49(1.13)  LDD1608  [1]
 LDCM0408  CL20 HEK-293T C49(1.08)  LDD1612  [1]
 LDCM0411  CL23 HEK-293T C49(1.08)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C49(1.05)  LDD1616  [1]
 LDCM0416  CL28 HEK-293T C49(0.85)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C49(1.05)  LDD1621  [1]
 LDCM0421  CL32 HEK-293T C49(1.07)  LDD1625  [1]
 LDCM0424  CL35 HEK-293T C49(1.06)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C49(1.06)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C49(0.81)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C49(0.92)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C49(1.07)  LDD1635  [1]
 LDCM0434  CL44 HEK-293T C49(1.08)  LDD1638  [1]
 LDCM0437  CL47 HEK-293T C49(1.14)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C49(0.96)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C49(1.01)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C49(0.75)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C49(1.13)  LDD1647  [1]
 LDCM0447  CL56 HEK-293T C49(1.06)  LDD1650  [1]
 LDCM0450  CL59 HEK-293T C49(1.02)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C49(0.99)  LDD1655  [1]
 LDCM0456  CL64 HEK-293T C49(0.96)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C49(1.14)  LDD1660  [1]
 LDCM0460  CL68 HEK-293T C49(1.13)  LDD1663  [1]
 LDCM0464  CL71 HEK-293T C49(1.13)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C49(1.07)  LDD1668  [1]
 LDCM0469  CL76 HEK-293T C49(1.09)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C49(1.10)  LDD1673  [1]
 LDCM0473  CL8 HEK-293T C49(1.13)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C49(1.04)  LDD1677  [1]
 LDCM0477  CL83 HEK-293T C49(1.24)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C49(1.03)  LDD1681  [1]
 LDCM0482  CL88 HEK-293T C49(0.95)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C49(1.02)  LDD1686  [1]
 LDCM0487  CL92 HEK-293T C49(0.97)  LDD1690  [1]
 LDCM0490  CL95 HEK-293T C49(1.17)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C49(1.19)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402