Details of the Target

General Information of Target

Target ID LDTP01122
Target Name Low-density lipoprotein receptor-related protein 4 (LRP4)
Gene Name LRP4
Gene ID 4038
Synonyms
KIAA0816; LRP10; MEGF7; Low-density lipoprotein receptor-related protein 4; LRP-4; Multiple epidermal growth factor-like domains 7
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH
SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNG
YCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE
NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS
GLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSD
EENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV
NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC
ETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRE
LVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL
DGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWP
NGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHT
KSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY
TCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW
DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRI
EVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISS
NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYW
TDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRS
PNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITM
KNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYW
TDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS
DRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTL
LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGC
SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP
VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR
NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN
LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPF
ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVN
NGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLY
SSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVV
IAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDH
NYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDT
ETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV
Target Bioclass
Transporter and channel
Family
LDLR family
Subcellular location
Cell membrane
Function
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation.
Uniprot ID
O75096
Ensemble ID
ENST00000378623.6
HGNC ID
HGNC:6696

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C331(0.77)  LDD3318  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C1814(1.09)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C1814(1.24)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C1814(1.02); C1043(1.27)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C1814(1.36); C736(1.12)  LDD1513  [3]
 LDCM0277  AC18 HEK-293T C1814(1.19)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C1814(1.28)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C1814(1.18)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C1814(1.06); C1043(1.02)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C1814(1.09); C1006(1.06)  LDD1520  [3]
 LDCM0283  AC23 HEK-293T C1814(0.87); C736(0.80)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C1814(1.16)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C1814(0.95)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C1814(1.01)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C1814(0.99); C1043(1.04)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C1814(1.19); C1006(1.04)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C1814(1.11)  LDD1529  [3]
 LDCM0292  AC31 HEK-293T C1814(0.91); C736(1.16)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C1814(1.26)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C1814(0.97)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C1814(1.03)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C1814(1.21); C1043(1.11)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C1814(1.02); C1006(1.03)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C1814(1.19); C736(0.90)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C1814(1.04); C1043(1.13)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C1814(1.03)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C1814(1.08)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C1814(0.90)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C1814(1.07); C1043(1.35)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C1814(1.36); C1006(1.11)  LDD1546  [3]
 LDCM0309  AC47 HEK-293T C1814(1.19); C736(1.23)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C1814(1.12)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C1814(1.04); C1006(1.26)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C1814(1.12)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C1814(1.29)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C1814(1.10); C1043(1.52)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C1814(1.23); C1006(1.07)  LDD1555  [3]
 LDCM0318  AC55 HEK-293T C1814(0.92); C736(0.94)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C1814(1.21)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C1814(1.22)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C1814(1.13)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C1814(1.14); C1043(1.40)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C1814(1.24); C1006(1.03)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C1814(0.86); C736(0.86)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C1814(1.26)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C1814(0.83); C736(0.88)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C1814(1.31)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C1814(1.07); C1006(1.52)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C1814(1.08)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C1814(0.97)  LDD1571  [3]
 LDCM0369  CL100 HEK-293T C1814(1.03); C1043(0.97)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C1814(1.11)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C1814(0.92); C1043(0.84)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C1814(0.99)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C1814(0.85); C1043(1.14)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C1814(0.97)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C1814(1.04); C1043(0.98)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C1814(1.10)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C1814(1.05); C1043(1.09)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C1814(1.04)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C1814(0.62); C736(1.13)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C1814(1.13); C1043(1.09)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C1814(1.05)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C1814(1.13); C1043(0.92)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C1814(1.02)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C1814(1.08); C1043(1.09)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C1814(1.05)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C1814(0.89); C1043(1.37)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C1814(0.93)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C1814(0.98); C1043(1.34)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C1814(0.95)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C1814(1.20)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C1814(0.88); C1043(1.26)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C1814(0.80)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C1814(1.59); C1043(0.87)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C1814(0.93)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C1814(1.17); C1043(0.86)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C1814(1.03)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C1814(0.94); C1043(0.91)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C1814(0.86)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C1814(1.01); C1043(1.07)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C1814(1.04)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C1814(1.27); C1043(0.98)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C1814(1.08)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C1814(1.05); C1043(1.15)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C1814(1.19)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C1814(0.97)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C1814(1.48); C1043(1.15)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C1814(1.09); C1043(1.03)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C1814(1.11); C1006(1.20)  LDD1613  [3]
 LDCM0411  CL23 HEK-293T C1814(1.06); C736(0.90)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C1814(1.34)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C1814(1.01)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C1814(1.32); C1043(0.87)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C1814(1.15)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C1814(1.53); C1043(1.19)  LDD1620  [3]
 LDCM0418  CL3 HEK-293T C1814(0.84)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C1814(0.98)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C1814(1.12)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C1814(1.11); C1043(0.90)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C1814(1.19); C1006(1.13)  LDD1626  [3]
 LDCM0424  CL35 HEK-293T C1814(1.23); C736(1.26)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C1814(1.10)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C1814(1.03)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C1814(0.91)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C1814(1.19); C1043(0.89)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C1814(0.75); C1043(0.94)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C1814(0.92)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C1814(0.86)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C1814(1.07); C1043(1.05)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C1814(1.45); C1006(0.88)  LDD1639  [3]
 LDCM0437  CL47 HEK-293T C1814(1.25); C736(0.95)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C1814(1.33)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C1814(0.92)  LDD1643  [3]
 LDCM0441  CL50 HEK-293T C1814(1.08); C1043(0.91)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C1814(0.96); C1043(1.08)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C1814(1.24)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C1814(0.94)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C1814(0.87); C1043(0.86)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C1814(1.10); C1006(1.34)  LDD1651  [3]
 LDCM0450  CL59 HEK-293T C1814(1.02); C736(1.16)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C1814(0.88)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C1814(1.06)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C1814(1.01)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C1814(0.97); C1043(1.27)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C1814(0.92)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C1814(0.96); C1043(1.07)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C1814(1.10)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C1814(1.04)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C1814(1.09); C1043(0.95)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C1814(1.22); C1006(1.03)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C1814(1.05)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C1814(1.12); C736(1.50)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C1814(1.00)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C1814(1.17)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C1814(1.07); C1043(0.93)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C1814(1.25); C1043(1.26)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C1814(1.17)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C1814(1.18)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C1814(0.85); C1043(1.13)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C1814(1.07); C1043(1.00)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C1814(1.19); C1006(0.98)  LDD1678  [3]
 LDCM0477  CL83 HEK-293T C1814(1.39); C736(0.89)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C1814(1.20)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C1814(0.91)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C1814(1.11); C1043(0.99)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C1814(0.88)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C1814(0.99); C1043(1.32)  LDD1685  [3]
 LDCM0484  CL9 HEK-293T C1814(1.14); C1006(1.19)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C1814(1.09)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C1814(1.04)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C1814(1.01); C1043(1.00)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C1814(1.16); C1006(1.09)  LDD1691  [3]
 LDCM0490  CL95 HEK-293T C1814(1.24); C736(1.38)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C1814(0.94)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C1814(0.87)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C1814(0.97); C1043(0.84)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C1814(0.88)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C1814(0.88)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C1814(1.03)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C1814(1.03); C1043(1.18)  LDD1631  [3]
 LDCM0022  KB02 A2780 C331(1.43)  LDD2254  [1]
 LDCM0023  KB03 A101D C331(1.46)  LDD2667  [1]
 LDCM0024  KB05 MELHO C331(0.77)  LDD3318  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sclerostin (SOST) Sclerostin family Q9BQB4

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402