Details of the Target

General Information of Target

Target ID LDTP01084
Target Name Cathepsin L2 (CTSV)
Gene Name CTSV
Gene ID 1515
Synonyms
CATL2; CTSL2; CTSU; Cathepsin L2; EC 3.4.22.43; Cathepsin U; Cathepsin V
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Peptidase C1 family
Subcellular location
Lysosome
Function Cysteine protease. May have an important role in corneal physiology.
TTD ID
T93653
Uniprot ID
O60911
DrugMap ID
TTSD9T1
Ensemble ID
ENST00000259470.6
HGNC ID
HGNC:2538
ChEMBL ID
CHEMBL3272

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C94(1.02)  LDD0602  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0285  AC25 HCT 116 C94(1.02)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C94(1.16)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C94(1.12)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C94(1.12)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C94(1.24)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C94(1.16)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C94(1.29)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C94(0.97)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C94(0.98)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C94(1.25)  LDD0612  [1]
 LDCM0308  AC46 HCT 116 C94(0.82)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C94(1.10)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C94(1.02)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C94(0.82)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C94(0.79)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C94(0.92)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C94(1.35)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C94(0.93)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C94(0.74)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C94(0.96)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C94(1.12)  LDD0636  [1]
 LDCM0349  AC83 HCT 116 C94(1.19)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C94(1.07)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C94(1.38)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C94(1.28)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C94(0.98)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C94(1.20)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C94(1.00)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C94(1.15)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C94(1.03)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C94(0.93)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C94(0.89)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C94(1.16)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C94(1.16)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C94(1.08)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C94(0.94)  LDD0681  [1]
 LDCM0382  CL112 HCT 116 C94(0.77)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C94(1.20)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C94(1.01)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C94(1.12)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C94(1.36)  LDD0703  [1]
 LDCM0392  CL121 HCT 116 C94(0.51)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C94(1.10)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C94(1.16)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C94(0.94)  LDD0712  [1]
 LDCM0420  CL31 HCT 116 C94(0.96)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C94(0.83)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C94(0.79)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C94(0.52)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C94(0.61)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C94(0.49)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C94(0.60)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C94(0.76)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C94(0.52)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C94(0.46)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C94(0.61)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C94(0.43)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C94(0.55)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C94(0.57)  LDD0752  [1]
 LDCM0427  Fragment51 HCT 116 C94(0.55)  LDD0744  [1]
 LDCM0022  KB02 DM93 C94(5.43)  LDD2472  [2]
 LDCM0023  KB03 DM93 C94(6.12)  LDD2889  [2]
 LDCM0024  KB05 DM93 C94(6.30)  LDD3306  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840