Details of the Target

General Information of Target

Target ID LDTP00817
Target Name Protein sprouty homolog 3 (SPRY3)
Gene Name SPRY3
Gene ID 10251
Synonyms
Protein sprouty homolog 3; Spry-3; Sprouty RTK signaling antagonist 3; Sprouty3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSSPSLIVQTHKSDWSLATMPT
SLPRSLSQCHQLQPLPQHLSQSSIASSMSHSTTASDQRLLASITPSPSGQSIIRTQPGAG
VHPKADGALKGEAEQSAGHPSEHLFICEECGRCKCVPCTAARPLPSCWLCNQRCLCSAES
LLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPSSCFVRWAAMSLISLFLPCLCCYLP
TRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKISSGSAPFPKAQEKSV
Target Bioclass
Other
Family
Sprouty family
Subcellular location
Cytoplasm
Function
Inhibits neurite branching, arbor length and neurite complexity. Inhibits EGF-mediated p42/44 ERK signaling. Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation. May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Uniprot ID
O43610
Ensemble ID
ENST00000302805.7
HGNC ID
HGNC:11271

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C270(1.01)  LDD3323  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C270(1.00)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C270(1.10)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C270(1.08)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C270(1.02)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C270(1.17)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C270(1.05)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C270(1.05)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C270(1.11)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C270(2.69)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C270(1.18)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C270(1.03)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C270(1.02)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C270(0.88)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C270(1.06)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C270(0.98)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C270(0.96)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C270(1.04)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C270(1.04)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C270(0.93)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C270(0.97)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C270(0.97)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C270(0.87)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C270(1.09)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C270(1.06)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C270(1.01)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C270(1.14)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C270(1.05)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C270(0.92)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C270(1.17)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C270(0.95)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C270(1.02)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C270(0.97)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C270(1.04)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C270(1.03)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C270(1.14)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C270(1.03)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C270(1.05)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C270(1.11)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C270(0.84)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C270(1.10)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C270(1.12)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C270(1.06)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C270(1.07)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C270(1.08)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C270(1.03)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C270(1.01)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C270(1.10)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C270(0.85)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C270(1.05)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C270(1.02)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C270(1.06)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C270(1.05)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C270(1.09)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C270(0.74)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C270(1.01)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C270(1.09)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C270(0.96)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C270(1.08)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C270(1.02)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C270(1.03)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C270(1.09)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C270(1.10)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C270(1.02)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C270(1.11)  LDD1514  [2]
 LDCM0368  CL10 HEK-293T C270(0.95)  LDD1572  [2]
 LDCM0371  CL102 HEK-293T C270(0.97)  LDD1575  [2]
 LDCM0375  CL106 HEK-293T C270(0.89)  LDD1579  [2]
 LDCM0379  CL11 HEK-293T C270(1.06)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C270(1.00)  LDD1584  [2]
 LDCM0384  CL114 HEK-293T C270(1.09)  LDD1588  [2]
 LDCM0388  CL118 HEK-293T C270(1.10)  LDD1592  [2]
 LDCM0390  CL12 HEK-293T C270(1.23)  LDD1594  [2]
 LDCM0393  CL122 HEK-293T C270(0.96)  LDD1597  [2]
 LDCM0397  CL126 HEK-293T C270(0.99)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C270(1.01)  LDD1605  [2]
 LDCM0404  CL17 HEK-293T C270(1.04)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C270(1.30)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C270(1.26)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C270(1.02)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C270(1.07)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C270(1.16)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C270(0.97)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C270(1.15)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C270(1.09)  LDD1616  [2]
 LDCM0414  CL26 HEK-293T C270(0.96)  LDD1618  [2]
 LDCM0417  CL29 HEK-293T C270(0.92)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C270(1.14)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C270(1.05)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C270(0.98)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C270(0.96)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C270(0.99)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C270(1.08)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C270(1.06)  LDD1629  [2]
 LDCM0431  CL41 HEK-293T C270(1.14)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C270(1.03)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C270(0.94)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C270(1.12)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C270(1.08)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C270(1.04)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C270(1.05)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C270(1.06)  LDD1642  [2]
 LDCM0440  CL5 HEK-293T C270(1.10)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C270(0.94)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C270(1.13)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C270(1.16)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C270(1.11)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C270(1.15)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C270(1.31)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C270(0.91)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C270(1.06)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C270(1.18)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C270(1.27)  LDD1655  [2]
 LDCM0454  CL62 HEK-293T C270(1.16)  LDD1657  [2]
 LDCM0457  CL65 HEK-293T C270(0.98)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C270(1.15)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C270(1.18)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C270(1.01)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C270(1.16)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C270(1.08)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C270(1.06)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C270(1.09)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C270(1.11)  LDD1668  [2]
 LDCM0467  CL74 HEK-293T C270(1.07)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C270(1.04)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C270(1.13)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C270(1.03)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C270(0.91)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C270(1.08)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C270(1.19)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C270(0.86)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C270(1.05)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C270(1.02)  LDD1681  [2]
 LDCM0480  CL86 HEK-293T C270(1.01)  LDD1683  [2]
 LDCM0483  CL89 HEK-293T C270(1.02)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C270(1.35)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C270(1.00)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C270(0.92)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C270(0.93)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C270(1.15)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C270(1.06)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C270(1.03)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C270(1.01)  LDD1694  [2]
 LDCM0493  CL98 HEK-293T C270(1.03)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C270(0.90)  LDD1631  [2]
 LDCM0022  KB02 22RV1 C270(1.73)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C270(2.12)  LDD2660  [1]
 LDCM0024  KB05 SKMEL24 C270(1.01)  LDD3323  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
Lysine-specific demethylase hairless (HR) . O43593
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Zinc transporter SLC39A7 (SLC39A7) ZIP transporter (TC 2.A.5) family Q92504
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX2 (BEX2) BEX family Q9BXY8
Chordin (CHRD) Chordin family Q9H2X0
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Late cornified envelope protein 1A (LCE1A) LCE family Q5T7P2
Late cornified envelope protein 1B (LCE1B) LCE family Q5T7P3
Late cornified envelope protein 1F (LCE1F) LCE family Q5T754
Late cornified envelope protein 2B (LCE2B) LCE family O14633
Late cornified envelope protein 3A (LCE3A) LCE family Q5TA76
Late cornified envelope protein 3D (LCE3D) LCE family Q9BYE3
Late cornified envelope protein 3E (LCE3E) LCE family Q5T5B0
Visinin-like protein 1 (VSNL1) Recoverin family P62760
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Keratinocyte proline-rich protein (KPRP) . Q5T749
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336
R3H domain-containing protein 2 (R3HDM2) . Q9Y2K5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402