Details of the Target

General Information of Target

Target ID LDTP00143
Target Name Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CSKMT)
Gene Name CSKMT
Gene ID 751071
Synonyms
METTL12; Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial; CS-KMT; EC 2.1.1.-; Methyltransferase-like protein 12, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALRRMLHLPSLMMGTCRPFAGSLADSCLADRCLWDRLHAQPRLGTVPTFDWFFGYDEV
QGLLLPLLQEAQAASPLRVLDVGCGTSSLCTGLYTKSPHPVDVLGVDFSPVAVAHMNSLL
EGGPGQTPLCPGHPASSLHFMHADAQNLGAVASSGSFQLLLDKGTWDAVARGGLPRAYQL
LSECLRVLNPQGTLIQFSDEDPDVRLPCLEQGSYGWTVTVQELGPFRGITYFAYLIQGSH
Target Bioclass
Enzyme
Family
Methyltransferase superfamily
Subcellular location
Mitochondrion
Function
Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event.
Uniprot ID
A8MUP2
Ensemble ID
ENST00000532971.2
HGNC ID
HGNC:33113

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C84(0.79); C90(0.79)  LDD0531  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C84(0.79); C90(0.79)  LDD0531  [1]
 LDCM0215  AC10 PaTu 8988t C84(0.77); C90(0.77)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C84(0.67); C90(0.67)  LDD1105  [1]
 LDCM0230  AC113 PaTu 8988t C84(1.35); C90(1.35)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C84(1.03); C90(1.03)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C84(1.12); C90(1.12)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C84(1.43); C90(1.43)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C84(1.18); C90(1.18)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C84(1.18); C90(1.18)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C84(1.07); C90(1.07)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C84(0.86); C90(0.86)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C84(1.15); C90(1.15)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C84(1.32); C90(1.32)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C84(1.23); C90(1.23)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C84(1.06); C90(1.06)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C84(1.22); C90(1.22)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C84(1.24); C90(1.24)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C84(1.46); C90(1.46)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C84(1.28); C90(1.28)  LDD1124  [1]
 LDCM0259  AC14 PaTu 8988t C84(0.78); C90(0.78)  LDD1138  [1]
 LDCM0263  AC143 HCT 116 C84(0.86); C90(0.86)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C84(0.63); C90(0.63)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C84(0.77); C90(0.77)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C84(0.61); C90(0.61)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C84(0.62); C90(0.62)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C84(0.78); C90(0.78)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C84(0.64); C90(0.64)  LDD0586  [1]
 LDCM0270  AC15 PaTu 8988t C84(0.74); C90(0.74)  LDD1149  [1]
 LDCM0271  AC150 HCT 116 C84(0.71); C90(0.71)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C84(0.79); C90(0.79)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C84(0.67); C90(0.67)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C84(0.79); C90(0.79)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C84(0.66); C90(0.66)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C84(0.66); C90(0.66)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C84(0.97); C90(0.97)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C84(0.97); C90(0.97)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C84(0.85); C90(0.85)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C84(0.67); C90(0.67)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C84(0.80); C90(0.80)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C84(0.61); C90(0.61)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C84(0.83); C90(0.83)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C84(0.69); C90(0.69)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C84(0.92); C90(0.92)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C84(0.92); C90(0.92)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C84(0.92); C90(0.92)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C84(0.86); C90(0.86)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C84(0.81); C90(0.81)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C84(0.75); C90(0.75)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C84(0.86); C90(0.86)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C84(0.74); C90(0.74)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C84(0.95); C90(0.95)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C84(0.74); C90(0.74)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C84(0.81); C90(0.81)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C84(0.83); C90(0.83)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C84(0.72); C90(0.72)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C84(0.70); C90(0.70)  LDD0612  [1]
 LDCM0301  AC4 HCT 116 C84(0.83); C90(0.83)  LDD0618  [1]
 LDCM0308  AC46 HCT 116 C84(0.99); C90(0.99)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C84(0.88); C90(0.88)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C84(0.84); C90(0.84)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C84(1.01); C90(1.01)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C84(0.75); C90(0.75)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C84(1.09); C90(1.09)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C84(1.10); C90(1.10)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C84(0.74); C90(0.74)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C84(0.97); C90(0.97)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C84(0.91); C90(0.91)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C84(1.03); C90(1.03)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C84(1.09); C90(1.09)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C84(0.64); C90(0.64)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C84(0.57); C90(0.57)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C84(0.60); C90(0.60)  LDD0639  [1]
 LDCM0323  AC6 PaTu 8988t C84(0.71); C90(0.71)  LDD1202  [1]
 LDCM0324  AC60 HCT 116 C84(0.54); C90(0.54)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C84(0.60); C90(0.60)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C84(0.63); C90(0.63)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C84(0.58); C90(0.58)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C84(0.64); C90(0.64)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C84(0.59); C90(0.59)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C84(0.62); C90(0.62)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C84(0.69); C90(0.69)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C84(1.06); C90(1.06)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C84(1.10); C90(1.10)  LDD0650  [1]
 LDCM0334  AC7 PaTu 8988t C84(0.68); C90(0.68)  LDD1213  [1]
 LDCM0335  AC70 HCT 116 C84(1.09); C90(1.09)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C84(0.93); C90(0.93)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C84(0.82); C90(0.82)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C84(1.22); C90(1.22)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C84(1.18); C90(1.18)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C84(1.21); C90(1.21)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C84(1.01); C90(1.01)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C84(0.89); C90(0.89)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C84(0.81); C90(0.81)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C84(0.87); C90(0.87)  LDD0661  [1]
 LDCM0345  AC8 PaTu 8988t C84(0.78); C90(0.78)  LDD1224  [1]
 LDCM0346  AC80 HCT 116 C84(0.74); C90(0.74)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C84(1.07); C90(1.07)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C84(1.47); C90(1.47)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C84(0.91); C90(0.91)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C84(0.95); C90(0.95)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C84(0.74); C90(0.74)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C84(0.78); C90(0.78)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C84(0.95); C90(0.95)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C84(1.02); C90(1.02)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C84(0.83); C90(0.83)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C84(1.22); C90(1.22)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C84(0.80); C90(0.80)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C84(0.78); C90(0.78)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C84(0.88); C90(0.88)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C84(0.88); C90(0.88)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C84(0.97); C90(0.97)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C84(0.91); C90(0.91)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C84(0.89); C90(0.89)  LDD0681  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C84(0.68); C90(0.68)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C84(0.85); C90(0.85)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C84(0.83); C90(0.83)  LDD1154  [1]
 LDCM0367  CL1 PaTu 8988t C84(0.79); C90(0.79)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C84(1.00); C90(1.00)  LDD1247  [1]
 LDCM0369  CL100 HCT 116 C84(0.93); C90(0.93)  LDD0686  [1]
 LDCM0370  CL101 PaTu 8988t C84(0.77); C90(0.77)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C84(0.85); C90(0.85)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C84(0.94); C90(0.94)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C84(0.80); C90(0.80)  LDD1252  [1]
 LDCM0374  CL105 HCT 116 C84(0.74); C90(0.74)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C84(0.69); C90(0.69)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C84(0.65); C90(0.65)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C84(0.64); C90(0.64)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C84(0.78); C90(0.78)  LDD0695  [1]
 LDCM0379  CL11 PaTu 8988t C84(0.84); C90(0.84)  LDD1258  [1]
 LDCM0380  CL110 HCT 116 C84(0.77); C90(0.77)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C84(0.88); C90(0.88)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C84(0.94); C90(0.94)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C84(0.87); C90(0.87)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C84(0.79); C90(0.79)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C84(0.81); C90(0.81)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C84(0.79); C90(0.79)  LDD0703  [1]
 LDCM0390  CL12 PaTu 8988t C84(0.84); C90(0.84)  LDD1269  [1]
 LDCM0392  CL121 HCT 116 C84(1.75); C90(1.75)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C84(0.78); C90(0.78)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C84(0.94); C90(0.94)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C84(0.95); C90(0.95)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C84(0.80); C90(0.80)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C84(0.78); C90(0.78)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C84(0.67); C90(0.67)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C84(0.60); C90(0.60)  LDD0716  [1]
 LDCM0400  CL13 PaTu 8988t C84(1.06); C90(1.06)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C84(1.25); C90(1.25)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C84(1.13); C90(1.13)  LDD1281  [1]
 LDCM0407  CL2 PaTu 8988t C84(0.94); C90(0.94)  LDD1286  [1]
 LDCM0418  CL3 PaTu 8988t C84(0.79); C90(0.79)  LDD1297  [1]
 LDCM0420  CL31 PaTu 8988t C84(0.81); C90(0.81)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C84(0.68); C90(0.68)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C84(0.82); C90(0.82)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C84(0.65); C90(0.65)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C84(0.84); C90(0.84)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C84(0.68); C90(0.68)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C84(0.84); C90(0.84)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C84(0.65); C90(0.65)  LDD1307  [1]
 LDCM0429  CL4 PaTu 8988t C84(0.76); C90(0.76)  LDD1308  [1]
 LDCM0430  CL40 PaTu 8988t C84(0.67); C90(0.67)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C84(0.77); C90(0.77)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C84(0.87); C90(0.87)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C84(0.82); C90(0.82)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C84(0.70); C90(0.70)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C84(0.88); C90(0.88)  LDD1314  [1]
 LDCM0440  CL5 PaTu 8988t C84(0.95); C90(0.95)  LDD1319  [1]
 LDCM0451  CL6 PaTu 8988t C84(0.80); C90(0.80)  LDD1330  [1]
 LDCM0453  CL61 HCT 116 C84(0.73); C90(0.73)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C84(0.72); C90(0.72)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C84(0.93); C90(0.93)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C84(0.62); C90(0.62)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C84(0.63); C90(0.63)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C84(0.61); C90(0.61)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C84(0.62); C90(0.62)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C84(0.67); C90(0.67)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C84(0.79); C90(0.79)  LDD0778  [1]
 LDCM0462  CL7 PaTu 8988t C84(0.81); C90(0.81)  LDD1341  [1]
 LDCM0463  CL70 HCT 116 C84(0.64); C90(0.64)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C84(0.76); C90(0.76)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C84(0.81); C90(0.81)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C84(0.79); C90(0.79)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C84(0.67); C90(0.67)  LDD0784  [1]
 LDCM0473  CL8 PaTu 8988t C84(0.99); C90(0.99)  LDD1352  [1]
 LDCM0484  CL9 PaTu 8988t C84(0.90); C90(0.90)  LDD1363  [1]
 LDCM0486  CL91 HCT 116 C84(0.79); C90(0.79)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C84(1.09); C90(1.09)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C84(0.73); C90(0.73)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C84(0.76); C90(0.76)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C84(0.62); C90(0.62)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C84(0.59); C90(0.59)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C84(0.87); C90(0.87)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C84(0.86); C90(0.86)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C84(0.71); C90(0.71)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C84(1.03); C90(1.03)  LDD0785  [1]
 LDCM0427  Fragment51 PaTu 8988t C84(0.67); C90(0.67)  LDD1306  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Tektin-5 (TEKT5) Tektin family Q96M29

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255