Details of the Target

General Information of Target

Target ID LDTP19692
Target Name von Willebrand factor A domain-containing protein 5B2 (VWA5B2)
Gene Name VWA5B2
Gene ID 90113
Synonyms
von Willebrand factor A domain-containing protein 5B2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESLQTPQHRENQDKREKEYGVKHMPMGNNAGNLEPEKRKAVRVALSSATAAQNIPSSVH
CGCSKQWRLRLPSESLQSRGQVMKRPNNILKLRNLDLLIYPWPELRRRQVASDLMSLLLL
PAFSGLTWAPFLFLFTYLPPFLNLLTVGFVSYFLV
Target Bioclass
Other
Uniprot ID
Q8N398
Ensemble ID
ENST00000426955.6
HGNC ID
HGNC:25144

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C946(1.31)  LDD0533  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C946(1.31)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C946(1.81)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C946(0.80)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C946(1.28)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C946(1.49)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C946(1.25)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C946(1.35)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C946(1.79)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C946(0.82)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C946(0.80)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C946(1.16)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C946(0.87)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C946(1.64)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C85(1.11); C86(1.11)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C85(1.34); C86(1.34)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C85(1.49); C86(1.49)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C85(1.16); C86(1.16)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C85(1.22); C86(1.22)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C85(1.69); C86(1.69)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C85(1.37); C86(1.37)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C85(1.32); C86(1.32)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C85(1.13); C86(1.13)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C85(1.42); C86(1.42)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C85(0.91); C86(0.91)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C85(1.17); C86(1.17)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C85(1.26); C86(1.26)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C85(1.46); C86(1.46)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C85(1.44); C86(1.44)  LDD0562  [1]
 LDCM0263  AC143 HCT 116 C85(1.14); C86(1.14)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C85(1.13); C86(1.13)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C85(0.91); C86(0.91)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C85(1.38); C86(1.38)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C85(1.25); C86(1.25)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C85(1.30); C86(1.30)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C85(1.08); C86(1.08)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C85(0.94); C86(0.94)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C85(0.96); C86(0.96)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C85(1.05); C86(1.05)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C85(1.29); C86(1.29)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C85(1.38); C86(1.38)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C85(1.38); C86(1.38)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C85(0.87); C86(0.87)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C85(1.13); C86(1.13)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C946(1.03)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C946(1.05)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C946(1.01)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C946(0.93)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C946(0.92)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C946(1.03)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C946(0.88)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C946(0.90)  LDD0601  [1]
 LDCM0320  AC57 HCT 116 C85(1.05); C86(1.05)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C85(1.17); C86(1.17)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C85(1.11); C86(1.11)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C85(1.02); C86(1.02)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C85(0.82); C86(0.82)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C85(1.15); C86(1.15)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C85(1.08); C86(1.08)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C85(1.00); C86(1.00)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C85(1.01); C86(1.01)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C85(0.89); C86(0.89)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C85(0.76); C86(0.76)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C85(1.09); C86(1.09)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C85(0.98); C86(0.98)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C85(1.10); C86(1.10)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C85(1.35); C86(1.35)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C85(1.14); C86(1.14)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C85(1.11); C86(1.11)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C85(1.02); C86(1.02)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C85(1.04); C86(1.04)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C85(1.33); C86(1.33)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C85(1.13); C86(1.13)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C85(1.08); C86(1.08)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C85(1.11); C86(1.11)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C85(1.01); C86(1.01)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C85(1.42); C86(1.42)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C85(1.26); C86(1.26)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C946(1.09)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C946(1.18)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C946(1.04)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C946(1.00)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C946(0.89)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C946(0.79)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C946(0.95)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C946(1.22)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C946(1.35)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C946(1.01)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C946(0.84)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C946(1.19)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C946(0.89)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C946(0.89)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C946(0.99)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C946(5.41)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C946(1.22)  LDD0683  [1]
 LDCM0020  ARS-1620 HCC44 C85(1.22); C86(1.22)  LDD2171  [1]
 LDCM0374  CL105 HCT 116 C946(1.11)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C946(0.95)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C946(1.12)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C946(1.11)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C946(1.09)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C946(0.85)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C946(1.01)  LDD0698  [1]
 LDCM0396  CL125 HCT 116 C85(1.01); C86(1.01)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C85(0.78); C86(0.78)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C85(0.97); C86(0.97)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C85(1.16); C86(1.16)  LDD0716  [1]
 LDCM0453  CL61 HCT 116 C946(0.85)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C946(0.88)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C946(1.13)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C946(1.57)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C946(0.91)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C946(1.32)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C946(1.16)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C946(1.44)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C946(1.08)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C946(1.11)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C946(0.94)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C946(0.87)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C946(1.01)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C946(1.17)  LDD0784  [1]
 LDCM0468  Fragment33 HCT 116 C946(1.16)  LDD0785  [1]
 LDCM0022  KB02 22RV1 C723(2.82)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C723(3.74)  LDD2660  [2]
 LDCM0024  KB05 NCI-H146 C723(3.84)  LDD3344  [2]
 LDCM0021  THZ1 HCT 116 C85(1.22); C86(1.22)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840