Details of the Target

General Information of Target

Target ID LDTP19342
Target Name Transcription elongation factor A protein-like 5 (TCEAL5)
Gene Name TCEAL5
Gene ID 340543
Synonyms
Transcription elongation factor A protein-like 5; TCEA-like protein 5; Transcription elongation factor S-II protein-like 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKTEETVLQNDPSVAENGAPEPKTPGQSQKSKSFCLDDQSPDLIETVNEVSKLSISHEI
VVNQDFYVEETILPPNSVEGRFAEAMYNAFWNHLKEQLLSTPPDFTCALELLKDVKETLL
SLLLPWQNRLRNEIEEALDTDLLKQEAEHGALDVPHLSNYILNLMALLCAPVRDEAIQKL
ETIRDPVQLLRGILRVLGLMKMDMVNYTIQSFRPYLQEHSIQYEQAKFQELLDKQPSLLD
YTTKWLTKAATDITTLCPSSPDSPSSSCSMACSLPSGAGNNSEPPSPTMVLYQGYLNLLL
WDLENVEFPETLLMDRIRLQELAFQLHQLTVLASVLLVARSFSGEVLFRSPEFVDRLKCT
TKALTEEFISRPEETMLSVSEQVSQEVHQGLKDMGLTTLSSENTASLLGQLQNITKKENC
IRSIVDQWIRFFLKCCLLHGMQESLLHFPGGLILIEKELAELGWKFLNLMHHNQQVFGPY
YAEILKHIIHPAQAQETDVEPN
Target Bioclass
Other
Family
TFS-II family, TFA subfamily
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q5H9L2
Ensemble ID
ENST00000372680.2
HGNC ID
HGNC:22282

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y111(17.29)  LDD3495  [1]
DBIA
 Probe Info  		C149(1.62)  LDD3310  [2]
BTD
 Probe Info  		C50(0.74)  LDD2141  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C149(1.07)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C149(1.06)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C149(0.94)  LDD1509  [5]
 LDCM0259  AC14 HEK-293T C149(1.06)  LDD1512  [5]
 LDCM0276  AC17 HEK-293T C149(1.11)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C149(1.06)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C149(0.96)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C149(1.07)  LDD1518  [5]
 LDCM0282  AC22 HEK-293T C149(1.10)  LDD1521  [5]
 LDCM0284  AC24 HEK-293T C149(1.01)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C149(1.07)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C149(0.88)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C149(0.97)  LDD1526  [5]
 LDCM0290  AC3 HEK-293T C149(1.10)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C149(1.01)  LDD1530  [5]
 LDCM0293  AC32 HEK-293T C149(0.98)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C149(1.04)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C149(1.06)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C149(1.07)  LDD1535  [5]
 LDCM0299  AC38 HEK-293T C149(1.08)  LDD1538  [5]
 LDCM0302  AC40 HEK-293T C149(0.86)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C149(1.15)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C149(1.03)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C149(1.25)  LDD1544  [5]
 LDCM0308  AC46 HEK-293T C149(1.06)  LDD1547  [5]
 LDCM0310  AC48 HEK-293T C149(1.04)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C149(1.01)  LDD1550  [5]
 LDCM0313  AC50 HEK-293T C149(0.92)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C149(1.02)  LDD1553  [5]
 LDCM0317  AC54 HEK-293T C149(1.01)  LDD1556  [5]
 LDCM0319  AC56 HEK-293T C149(1.34)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C149(0.94)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C149(0.94)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C149(1.00)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C149(1.07)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C149(1.00)  LDD1565  [5]
 LDCM0328  AC64 HEK-293T C149(1.11)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C149(1.01)  LDD1569  [5]
 LDCM0356  AKOS034007680 HEK-293T C149(0.99)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C149(0.91)  LDD1514  [5]
 LDCM0368  CL10 HEK-293T C149(0.91)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C149(0.78)  LDD1573  [5]
 LDCM0371  CL102 HEK-293T C50(1.01)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C149(1.03)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C149(0.86)  LDD1577  [5]
 LDCM0375  CL106 HEK-293T C50(1.01)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C149(1.11)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C149(0.97)  LDD1581  [5]
 LDCM0380  CL110 HEK-293T C50(0.91)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C149(0.99)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C149(1.00)  LDD1586  [5]
 LDCM0384  CL114 HEK-293T C50(1.02)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C149(1.06)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C149(0.89)  LDD1590  [5]
 LDCM0388  CL118 HEK-293T C50(1.02)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C149(1.02)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C149(0.91)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C149(0.83)  LDD1595  [5]
 LDCM0393  CL122 HEK-293T C50(1.08)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C149(0.93)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C149(0.82)  LDD1599  [5]
 LDCM0397  CL126 HEK-293T C50(1.16)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C149(0.97)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C149(0.95)  LDD1603  [5]
 LDCM0401  CL14 HEK-293T C50(0.94)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C149(0.94)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C149(0.88)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C149(0.86)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C149(1.07)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C149(1.07)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C50(1.04)  LDD1611  [5]
 LDCM0410  CL22 HEK-293T C149(1.08)  LDD1614  [5]
 LDCM0412  CL24 HEK-293T C149(1.03)  LDD1616  [5]
 LDCM0414  CL26 HEK-293T C50(1.01)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C149(0.99)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C149(0.93)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C149(1.10)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C149(0.93)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C149(1.02)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C149(1.08)  LDD1624  [5]
 LDCM0423  CL34 HEK-293T C149(0.99)  LDD1627  [5]
 LDCM0425  CL36 HEK-293T C149(1.23)  LDD1629  [5]
 LDCM0428  CL39 HEK-293T C149(1.36)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C149(0.82)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C149(1.10)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C149(0.98)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C149(1.14)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C149(1.09)  LDD1637  [5]
 LDCM0436  CL46 HEK-293T C149(1.10)  LDD1640  [5]
 LDCM0438  CL48 HEK-293T C149(1.26)  LDD1642  [5]
 LDCM0440  CL5 HEK-293T C149(1.06)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C50(1.06)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C149(0.73)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C149(1.10)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C149(0.94)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C149(1.06)  LDD1649  [5]
 LDCM0449  CL58 HEK-293T C149(1.01)  LDD1652  [5]
 LDCM0451  CL6 HEK-293T C149(0.82)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C149(1.11)  LDD1655  [5]
 LDCM0454  CL62 HEK-293T C50(1.07)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C149(1.11)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C149(0.88)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C149(1.09)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C149(1.16)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C149(1.31)  LDD1662  [5]
 LDCM0462  CL7 HEK-293T C149(1.14)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C149(1.12)  LDD1666  [5]
 LDCM0465  CL72 HEK-293T C149(1.40)  LDD1668  [5]
 LDCM0467  CL74 HEK-293T C50(1.10)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C149(0.80)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C149(0.87)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C149(1.03)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C149(0.88)  LDD1675  [5]
 LDCM0476  CL82 HEK-293T C149(1.09)  LDD1679  [5]
 LDCM0478  CL84 HEK-293T C149(1.11)  LDD1681  [5]
 LDCM0480  CL86 HEK-293T C50(1.46)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C149(0.96)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C149(0.76)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C149(1.03)  LDD1686  [5]
 LDCM0485  CL90 HEK-293T C149(0.83)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C149(0.94)  LDD1689  [5]
 LDCM0489  CL94 HEK-293T C149(1.24)  LDD1692  [5]
 LDCM0491  CL96 HEK-293T C149(1.06)  LDD1694  [5]
 LDCM0493  CL98 HEK-293T C50(0.96)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C149(1.00)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C149(1.31)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C149(0.94)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C50(1.01)  LDD1631  [5]
 LDCM0022  KB02 22RV1 C149(2.03)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C149(1.93)  LDD2660  [2]
 LDCM0024  KB05 COLO792 C149(1.62)  LDD3310  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C50(0.74)  LDD2141  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor subfamily 4 group A member 2 (NR4A2) Nuclear hormone receptor family P43354

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402