Details of the Target

General Information of Target

Target ID LDTP19309
Target Name Protein MIX23 (MIX23)
Gene Name MIX23
Gene ID 131076
Synonyms
CCDC58; Protein MIX23; Coiled-coil domain-containing protein 58
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMNLEKNFDKTTLFNHMRTDKRGKCSDLNEYGTSCDKTTAVEYNKVHMAMTHYECNERGI
NFSRKSPLTQSQRTITGWSAFESNKCEENFSQSSAHIVHQKTQAGDKFGEHNECTDALYQ
KLDFTAHQRIHTDFTAHQKFYLSDEHGKCRKSFYWKAHLIQHERPHSGEKTYQYEECAKS
FCSSSHPIQHPGTYVGFKLYECNECGKAFCQNSNLSKHLRIHTKEKPCDNNGCGRSYKSP
LIGHQKTDAEMELCGGSEYGKTSHLKGHQRILMGEKPYECIECGKTFSKTSHLRAHQRIH
TGEKPYECVECEKTFSHKTHLSVHQRVHTGEKPYECNDCGKSFTYNSALRAHQRIHTGEK
PYECSDCEKTFAHNSALRAHHRIHTGEKPYECNECGRSFAHISVLKAHQRIHTREKPYEC
NECGRSFTYNSALRAHQRIHTGRKPYECSDCEKTFAHNSALKIHQRIHTGEKPYKCNECE
KTFAHNSALRAHQNIHTGEKLYECSECGKTFFQKTRLSTHRRIHTGEKPYECSKCGKTFS
QKSYLSGHERIHTGEKPYECNVCGKTFVYKAALIVHQRIHTGEKPYECNECGKTFSQRTH
LCAHQRIHTGEKPYECNECGKTFADNSALRAHHRIHTGEKPYECNDCGKTFSKTSHLRAH
LRTRSGEKPYECSECGKTFSEKSYVSAHQRVHTGEKPYECNVCGKPFAHNSTLRVHQRIH
TGEKSYECNDCGKTFSQKSHLSAHQRIHTGEKPYECNECGKAFAQNSTLRVHQRIHTGEK
PYECDECGKTFVRKAALRVHHTRMHTREKTLACNGFGKS
Target Bioclass
Other
Family
MIX23 family
Uniprot ID
Q4VC31
Ensemble ID
ENST00000291458.9
HGNC ID
HGNC:31136

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C53(2.36)  LDD3370  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
IA-alkyne
 Probe Info  		C53(0.00); C74(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		C74(0.00); C10(0.00)  LDD0026  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
NHS
 Probe Info  		N.A.  LDD0010  [6]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		C53(0.00); C74(0.00); C10(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C74(1.32)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C74(1.23)  LDD1510  [10]
 LDCM0270  AC15 HEK-293T C74(1.29)  LDD1513  [10]
 LDCM0278  AC19 HEK-293T C74(1.98)  LDD1517  [10]
 LDCM0280  AC20 HEK-293T C74(1.06)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C74(0.91)  LDD1520  [10]
 LDCM0283  AC23 HEK-293T C74(0.80)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C74(1.01)  LDD1523  [10]
 LDCM0287  AC27 HEK-293T C74(1.16)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C74(1.58)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C74(1.03)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C74(1.22)  LDD1529  [10]
 LDCM0292  AC31 HEK-293T C74(1.15)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C74(0.94)  LDD1532  [10]
 LDCM0296  AC35 HEK-293T C74(1.16)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C74(0.84)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C74(0.82)  LDD1537  [10]
 LDCM0300  AC39 HEK-293T C74(1.04)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C74(1.10)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C74(1.18)  LDD1541  [10]
 LDCM0305  AC43 HEK-293T C74(1.19)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C74(1.15)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C74(1.07)  LDD1546  [10]
 LDCM0309  AC47 HEK-293T C74(1.00)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C74(1.03)  LDD1549  [10]
 LDCM0312  AC5 HEK-293T C74(0.92)  LDD1551  [10]
 LDCM0314  AC51 HEK-293T C74(1.08)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C74(1.02)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C74(1.33)  LDD1555  [10]
 LDCM0318  AC55 HEK-293T C74(1.04)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C74(0.95)  LDD1558  [10]
 LDCM0322  AC59 HEK-293T C74(1.12)  LDD1561  [10]
 LDCM0324  AC60 HEK-293T C74(0.86)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C74(1.05)  LDD1564  [10]
 LDCM0327  AC63 HEK-293T C74(0.94)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C74(0.80)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C74(1.05)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C74(1.16)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C74(1.14)  LDD1511  [10]
 LDCM0275  AKOS034007705 HEK-293T C74(1.13)  LDD1514  [10]
 LDCM0367  CL1 HEK-293T C74(0.95)  LDD1571  [10]
 LDCM0370  CL101 HEK-293T C74(0.98)  LDD1574  [10]
 LDCM0372  CL103 HEK-293T C74(0.99)  LDD1576  [10]
 LDCM0374  CL105 HEK-293T C74(0.99)  LDD1578  [10]
 LDCM0376  CL107 HEK-293T C74(1.01)  LDD1580  [10]
 LDCM0378  CL109 HEK-293T C74(0.92)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C74(0.91)  LDD1583  [10]
 LDCM0381  CL111 HEK-293T C74(0.83)  LDD1585  [10]
 LDCM0383  CL113 HEK-293T C74(0.97)  LDD1587  [10]
 LDCM0385  CL115 HEK-293T C74(1.17)  LDD1589  [10]
 LDCM0387  CL117 HEK-293T C74(0.99)  LDD1591  [10]
 LDCM0389  CL119 HEK-293T C74(1.06)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C74(0.81)  LDD1594  [10]
 LDCM0392  CL121 HEK-293T C74(0.99)  LDD1596  [10]
 LDCM0394  CL123 HEK-293T C74(0.92)  LDD1598  [10]
 LDCM0396  CL125 HEK-293T C74(0.91)  LDD1600  [10]
 LDCM0398  CL127 HEK-293T C74(0.97)  LDD1602  [10]
 LDCM0400  CL13 HEK-293T C74(1.01)  LDD1604  [10]
 LDCM0402  CL15 HEK-293T C74(1.81)  LDD1606  [10]
 LDCM0406  CL19 HEK-293T C74(1.39)  LDD1610  [10]
 LDCM0408  CL20 HEK-293T C74(1.25)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C74(0.88)  LDD1613  [10]
 LDCM0411  CL23 HEK-293T C74(0.87)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C74(1.90)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C74(1.03)  LDD1617  [10]
 LDCM0415  CL27 HEK-293T C74(0.90)  LDD1619  [10]
 LDCM0418  CL3 HEK-293T C74(1.25)  LDD1622  [10]
 LDCM0420  CL31 HEK-293T C74(1.37)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C74(1.03)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C74(1.21)  LDD1626  [10]
 LDCM0424  CL35 HEK-293T C74(0.85)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C74(1.11)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C74(0.93)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C74(0.96)  LDD1632  [10]
 LDCM0433  CL43 HEK-293T C74(1.04)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C74(1.32)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C74(1.06)  LDD1639  [10]
 LDCM0437  CL47 HEK-293T C74(0.97)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C74(0.81)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C74(1.02)  LDD1643  [10]
 LDCM0446  CL55 HEK-293T C74(1.11)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C74(1.08)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C74(0.88)  LDD1651  [10]
 LDCM0450  CL59 HEK-293T C74(0.86)  LDD1653  [10]
 LDCM0452  CL60 HEK-293T C74(0.86)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C74(0.85)  LDD1656  [10]
 LDCM0455  CL63 HEK-293T C74(0.83)  LDD1658  [10]
 LDCM0459  CL67 HEK-293T C74(1.35)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C74(1.14)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C74(1.21)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C74(1.16)  LDD1665  [10]
 LDCM0464  CL71 HEK-293T C74(1.06)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C74(1.15)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C74(0.97)  LDD1669  [10]
 LDCM0472  CL79 HEK-293T C74(1.04)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C74(0.61)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C74(0.86)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C74(0.92)  LDD1678  [10]
 LDCM0477  CL83 HEK-293T C74(0.92)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C74(0.93)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C74(0.90)  LDD1682  [10]
 LDCM0481  CL87 HEK-293T C74(0.99)  LDD1684  [10]
 LDCM0484  CL9 HEK-293T C74(0.95)  LDD1687  [10]
 LDCM0486  CL91 HEK-293T C74(1.20)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C74(1.22)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C74(0.94)  LDD1691  [10]
 LDCM0490  CL95 HEK-293T C74(0.91)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C74(1.00)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C74(1.06)  LDD1695  [10]
 LDCM0494  CL99 HEK-293T C74(0.86)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C74(1.32)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C74(0.87)  LDD1671  [10]
 LDCM0022  KB02 K052 C53(3.14)  LDD2427  [1]
 LDCM0023  KB03 MDA-MB-231 C74(0.96)  LDD1701  [11]
 LDCM0024  KB05 OCI-AML-2 C53(2.36)  LDD3370  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761