Details of the Target

General Information of Target

Target ID LDTP19059
Target Name DDB1- and CUL4-associated factor 8-like protein 2 (DCAF8L2)
Gene Name DCAF8L2
Synonyms
WDR42C; DDB1- and CUL4-associated factor 8-like protein 2; WD repeat-containing protein 42C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRDLEQALDRTENITEIAQQRRPRRRYSPRAGKTLQEKLYDIYVEECGKEPEDPQELRS
NVNLLEKLVRRESLPCLLVNLYPGNQGYSVMLQREDGSFAETIRLPYEERALLDYLDAEE
LPPALGDVLDKASVNIFHSGCVIVEVRDYRQSSNMQPPGYQSRHILLRPTMQTLAPEVKT
MTRDGEKWSQEDKFPLESQLILATAEPLCLDPSVAVACTANRLLYNKQKMNTDPMEQCLQ
RYSWPSVKPQQEQSDCPPPPELRVSTSGQKEERKVGQPCELNITKAGSCVDTWKGRPCDL
AVPSEVDVEKLAKGYQSVTAADPQLPVWPAQEVEDPFRHAWEAGCQAWDTKPNIMQSFND
PLLCGKIRPRKKARQKSQKSPWQPFPDDHSACLRPGSETDAGRAVSQAQESVQSKVKGPG
KMSHSSSGPASVSQLSSWKTPEQPDPVWVQSSVSGKGEKHPPPRTQLPSSSGKISSGNSF
PPQQAGSPLKRPFPAAAPAVAAAAPAPAPAPAAAPALAAAAVAAAAGGAAPSHSQKPSVP
LIKASRRRPAAGRPTRFVKIAPAIQVRTGSTGLKATNVEGPVRGAQVLGCSFKPVQAPGS
GAPAPAGISGSGLQSSGGPLPDARPGAVQASSPAPLQFFLNTPEGLRPLTLQVPQGWAVL
TGPQQQSHQLVSLQQLQQPTAAHPPQPGPQGSTLGLSTQGQAFPAQQLLNVNLTGAGSGL
QPQPQAAVLSLLGSAQVPQQGVQLPFVLGQQPQPLLLLQPQPQPQQIQLQTQPLRVLQQP
VFLATGAVQIVQPHPGVQAGSQLVGQRKGGKPTPPAP
Target Bioclass
Enzyme
Family
WD repeat DCAF8 family
Uniprot ID
P0C7V8
Ensemble ID
ENST00000451261.7
HGNC ID
HGNC:31811

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C209(0.87)  LDD0533  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]
HHS-465
 Probe Info  		N.A.  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C209(0.87)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C209(1.22)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C209(0.91)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C209(1.09)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C209(1.55)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C209(0.88)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C209(1.14)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C209(1.29)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C209(1.04)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C209(0.94)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C209(0.94)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C209(1.10)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C209(1.02)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C209(0.83)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C209(0.89)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C209(0.83)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C209(1.06)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C209(0.94)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C209(0.96)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C209(1.06)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C209(0.91)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C209(0.95)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C209(1.01)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C209(0.88)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C209(0.90)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C209(0.92)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C209(1.01)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C209(0.92)  LDD0562  [1]
 LDCM0365  AC98 HCT 116 C209(0.99)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C209(1.05)  LDD0683  [1]
 LDCM0367  CL1 HCT 116 C209(0.86)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C209(1.14)  LDD0685  [1]
 LDCM0379  CL11 HCT 116 C209(0.94)  LDD0696  [1]
 LDCM0390  CL12 HCT 116 C209(1.12)  LDD0707  [1]
 LDCM0400  CL13 HCT 116 C209(1.13)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C209(0.83)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C209(0.72)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C209(0.82)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C209(0.94)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C209(1.14)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C209(1.01)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C209(0.80)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C209(0.93)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C209(1.10)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C209(1.06)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C209(0.87)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C209(1.02)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C209(1.00)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C209(0.93)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C209(1.05)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C209(0.92)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C209(0.93)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C209(0.94)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C209(0.88)  LDD0736  [1]
 LDCM0429  CL4 HCT 116 C209(1.02)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C209(0.95)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C209(1.31)  LDD0768  [1]
 LDCM0453  CL61 HCT 116 C209(0.76)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C209(0.87)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C209(0.90)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C209(1.10)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C209(0.77)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C209(0.71)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C209(0.76)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C209(0.83)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C209(0.90)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C209(1.26)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C209(0.76)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C209(0.67)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C209(1.15)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C209(0.77)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C209(0.83)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C209(0.93)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C209(0.90)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C209(1.10)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C209(1.38)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C209(0.97)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C209(0.91)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C209(0.94)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C209(1.37)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C209(1.17)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C209(1.30)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C209(1.19)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C209(1.07)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C209(1.51)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C209(1.05)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C209(1.26)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C209(0.96)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C209(1.02)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C209(0.63)  LDD0785  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010