Details of the Target

General Information of Target

Target ID LDTP18266
Target Name Methyltransferase-like 26 (METTL26)
Gene Name METTL26
Gene ID 84326
Synonyms
JFP2; Methyltransferase-like 26
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVKLGDGGSGEDGLKKLGKRAADEESLEGEGAGGADAAEESSGTKRDEKTPRAGADGPP
APPGAPQAPSPPQGSPQDQHHFLRSSVRPQSKRPRKDPPSAVGSGNAGGSGPRGKGAEGG
GSSSGNVSGVAPAAPAGGSRSSSRNLGSSGGEKEEGKKVRRQWESWSTEDKNTFFEGLYE
HGKDFEAIQNNIALKYKKKGKPASMVKNKEQVRHFYYRTWHKITKYIDFDHVFSRGLKKS
SQELYGLICYGELRKKIGGCMDDKNATKLNELIQVGATTVRYKGRNLRIKAPMCRALKKL
CDPDGLSDEEDQKPVRLPLKVPIELQPRNNHAWARVQSLAQNPRLRMIVELHRKVSSLIE
FLKQKWALHEVRVRKTLEERQLQDSCSAPMQEKVTLHLFPGENCTLTPLPGVARVVHSKA
FCTVHWQEGGRCKQSAKDAHVLPPAQILGIQSGQGTARGQVKCPRSGAEGKGVGRPPPAA
DALQSSGESSPESAPGEGAALSLSSPDAPDRPPPRHQDTGPCLEKTPAEGRDSPTREPGA
LPCACGQLPDLEDELSLLDPLPRYLKSCQDLIVPEQCRCADTRPGSEQPPLGGAASPEVL
APVSKEAADLAPTGPSPRPGPGLLLDVCTKDLADAPAEELQEKGSPAGPPPSQGQPAARP
PKEVPASRLAQQLREEGWNLQTSESLTLAEVYLMMGKPSKLQLEYDWLGPGRQDPRPGSL
PTALHKQRLLSCLLKLISTEVNPKLALEANTISTASVRPAQEEQSMTPPGKVVTVSSRSP
RCPRNQASLRSSKTFPPSSAPCSSGLRNPPRPLLVPGPSSTGSNDSDGGLFAVPTTLPPN
SRHGKLFSPSKEAELTFRQHLNSISMQSDFFLPKPRKLRNRHLRKPLVVQRTLLPRPSEN
QSHNVCSFSILSNSSVTGRGSFRPIQSSLTKAALSRPIVPKVLPPQATSHLASAIDLAAT
SAGILSGNPLPALDTEGLSGISPLSSDEVTGAISGQDSTGTHQDGDTLPTVGGSDPFVSI
PSRPEQEPVADSFQGSSVLSLSELPKAPLQNGLSIPLSSSESSSTRLSPPDVSALLDISL
PGPPEDALSQGEPATHISDSIIEIAISSGQYGEGVPLSPAKLNGSDSSKSLPSPSSSPQP
HWIASPTHDPQWYPSDSTDSSLSSLFASFISPEKSRKMLPTPIGTNSGTSLLGPSLLDGN
SRDSFVSRSLADVAEVVDSQLVCMMNENSIDYISRFNDLAQELSIAEPGRREALFDGGGG
GPAVSDLSQ
Target Bioclass
Other
Family
UPF0585 family
Uniprot ID
Q96S19
Ensemble ID
ENST00000301686.13
HGNC ID
HGNC:14141

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.11  LDD0403  [1]
DBIA
 Probe Info  		C118(12.07)  LDD0209  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C162(0.00); C118(0.00); C63(0.00)  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
NAIA_5
 Probe Info  		C63(0.00); C162(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C63(1.14)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C63(1.02)  LDD1512  [7]
 LDCM0280  AC20 HEK-293T C63(1.10)  LDD1519  [7]
 LDCM0282  AC22 HEK-293T C63(1.17)  LDD1521  [7]
 LDCM0284  AC24 HEK-293T C118(1.57)  LDD1523  [7]
 LDCM0288  AC28 HEK-293T C63(1.14)  LDD1527  [7]
 LDCM0291  AC30 HEK-293T C63(1.05)  LDD1530  [7]
 LDCM0293  AC32 HEK-293T C118(1.14)  LDD1532  [7]
 LDCM0297  AC36 HEK-293T C63(1.18)  LDD1536  [7]
 LDCM0299  AC38 HEK-293T C63(0.95)  LDD1538  [7]
 LDCM0301  AC4 HEK-293T C63(1.06)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C118(1.25)  LDD1541  [7]
 LDCM0306  AC44 HEK-293T C63(1.26)  LDD1545  [7]
 LDCM0308  AC46 HEK-293T C63(1.03)  LDD1547  [7]
 LDCM0310  AC48 HEK-293T C118(1.58)  LDD1549  [7]
 LDCM0315  AC52 HEK-293T C63(1.12)  LDD1554  [7]
 LDCM0317  AC54 HEK-293T C63(1.03)  LDD1556  [7]
 LDCM0319  AC56 HEK-293T C118(1.60)  LDD1558  [7]
 LDCM0323  AC6 HEK-293T C63(0.91)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C63(1.05)  LDD1563  [7]
 LDCM0326  AC62 HEK-293T C63(1.11)  LDD1565  [7]
 LDCM0328  AC64 HEK-293T C118(1.47)  LDD1567  [7]
 LDCM0345  AC8 HEK-293T C118(1.26)  LDD1569  [7]
 LDCM0275  AKOS034007705 HEK-293T C118(1.57)  LDD1514  [7]
 LDCM0156  Aniline NCI-H1299 13.11  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C63(20.00); C162(20.00)  LDD2227  [6]
 LDCM0368  CL10 HEK-293T C63(0.64)  LDD1572  [7]
 LDCM0390  CL12 HEK-293T C118(1.30)  LDD1594  [7]
 LDCM0408  CL20 HEK-293T C63(1.26)  LDD1612  [7]
 LDCM0410  CL22 HEK-293T C63(0.89)  LDD1614  [7]
 LDCM0412  CL24 HEK-293T C118(1.49)  LDD1616  [7]
 LDCM0421  CL32 HEK-293T C63(1.13)  LDD1625  [7]
 LDCM0423  CL34 HEK-293T C63(0.78)  LDD1627  [7]
 LDCM0425  CL36 HEK-293T C118(1.56)  LDD1629  [7]
 LDCM0434  CL44 HEK-293T C63(1.19)  LDD1638  [7]
 LDCM0436  CL46 HEK-293T C63(0.84)  LDD1640  [7]
 LDCM0438  CL48 HEK-293T C118(1.39)  LDD1642  [7]
 LDCM0447  CL56 HEK-293T C63(1.28)  LDD1650  [7]
 LDCM0449  CL58 HEK-293T C63(0.72)  LDD1652  [7]
 LDCM0452  CL60 HEK-293T C118(1.69)  LDD1655  [7]
 LDCM0460  CL68 HEK-293T C63(1.29)  LDD1663  [7]
 LDCM0463  CL70 HEK-293T C63(0.82)  LDD1666  [7]
 LDCM0465  CL72 HEK-293T C118(1.66)  LDD1668  [7]
 LDCM0473  CL8 HEK-293T C63(1.11)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C63(1.15)  LDD1677  [7]
 LDCM0476  CL82 HEK-293T C63(0.88)  LDD1679  [7]
 LDCM0478  CL84 HEK-293T C118(1.25)  LDD1681  [7]
 LDCM0487  CL92 HEK-293T C63(1.25)  LDD1690  [7]
 LDCM0489  CL94 HEK-293T C63(1.00)  LDD1692  [7]
 LDCM0491  CL96 HEK-293T C118(1.37)  LDD1694  [7]
 LDCM0573  Fragment11 Ramos C162(11.16)  LDD2190  [8]
 LDCM0576  Fragment14 Ramos C162(0.57)  LDD2193  [8]
 LDCM0586  Fragment28 Ramos C162(1.55)  LDD2198  [8]
 LDCM0566  Fragment4 Ramos C162(0.92)  LDD2184  [8]
 LDCM0569  Fragment7 Ramos C162(0.94)  LDD2186  [8]
 LDCM0022  KB02 Ramos C162(0.82)  LDD2182  [8]
 LDCM0023  KB03 Jurkat C118(12.07)  LDD0209  [2]
 LDCM0024  KB05 IGR37 C118(1.08)  LDD3314  [9]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840