Details of the Target

General Information of Target

Target ID LDTP18207
Target Name Coenzyme Q-binding protein COQ10 homolog A, mitochondrial (COQ10A)
Gene Name COQ10A
Gene ID 93058
Synonyms
Coenzyme Q-binding protein COQ10 homolog A, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSRLGAVPATSGPTTFKQQRSTRIVGAKNSRTQCSIKDNSFQYTIPHDDSLSGSSSASS
CEPVSDFPASFRKSTYWMKMRRIKPAATSHVEGSGGVSAKGKRKPRQEEDEDYREFPQKK
HKLYGRKQRPKTQPNPKSQARRIRKEPPVYAAGSLEEQWYLEIVDKGSVSCPTCQAVGRK
TIEGLKKHMENCKQEMFTCHHCGKQLRSLAGMKYHVMANHNSLPILKAGDEIDEPSERER
LRTVLKRLGKLRCMRESCSSSFTSIMGYLYHVRKCGKGAAELEKMTLKCHHCGKPYRSKA
GLAYHLRSEHGPISFFPESGQPECLKEMNLESKSGGRVQRRSAKIAVYHLQELASAELAK
EWPKRKVLQDLVPDDRKLKYTRPGLPTFSQEVLHKWKTDIKKYHRIQCPNQGCEAVYSSV
SGLKAHLGSCTLGNFVAGKYKCLLCQKEFVSESGVKYHINSVHAEDWFVVNPTTTKSFEK
LMKIKQRQQEEEKRRQQHRSRRSLRRRQQPGIELPETELSLRVGKDQRRNNEELVVSASC
KEPEQEPVPAQFQKVKPPKTNHKRGRK
Target Bioclass
Other
Family
COQ10 family
Subcellular location
Mitochondrion inner membrane
Function
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).
Uniprot ID
Q96MF6
Ensemble ID
ENST00000308197.10
HGNC ID
HGNC:26515

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DANG SNV: p.R42G .
HT115 SNV: p.R84Q .
MOLT4 SNV: p.A148V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C85(4.81)  LDD3352  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C117(0.74); C161(0.95)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C117(1.12); C161(0.98)  LDD1509  [2]
 LDCM0270  AC15 HEK-293T C117(0.95); C161(1.04)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C117(0.93); C161(1.02)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C117(0.87); C161(0.86)  LDD1517  [2]
 LDCM0283  AC23 HEK-293T C117(1.10); C161(0.92)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C117(1.08)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C117(0.92); C161(0.90)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C117(0.91); C161(1.06)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C117(0.86); C161(1.08)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C117(1.12); C161(1.06)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C117(1.02)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C117(0.92); C161(1.04)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C117(0.95); C161(0.92)  LDD1535  [2]
 LDCM0300  AC39 HEK-293T C117(0.91); C161(0.90)  LDD1539  [2]
 LDCM0302  AC40 HEK-293T C117(0.93)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C117(0.91); C161(0.87)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C117(1.11); C161(1.03)  LDD1544  [2]
 LDCM0309  AC47 HEK-293T C117(1.06); C161(0.98)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C117(0.90)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C117(1.00); C161(0.94)  LDD1550  [2]
 LDCM0314  AC51 HEK-293T C117(1.02); C161(1.02)  LDD1553  [2]
 LDCM0318  AC55 HEK-293T C117(1.04); C161(0.98)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C117(0.98)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C117(0.93); C161(0.93)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C117(0.99); C161(1.23)  LDD1561  [2]
 LDCM0327  AC63 HEK-293T C117(0.93); C161(0.92)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C117(0.89)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C117(1.07); C161(0.95)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C117(0.85)  LDD1569  [2]
 LDCM0356  AKOS034007680 HEK-293T C117(0.99); C161(0.91)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C117(0.94)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C117(1.06)  LDD1571  [2]
 LDCM0369  CL100 HEK-293T C117(1.00); C161(1.00)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C117(0.95)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C117(1.00); C161(1.02)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C117(1.10)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C117(1.21); C161(1.00)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C117(0.96)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C117(0.96); C161(0.95)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C117(1.16)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C117(1.30); C161(1.09)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C117(1.02)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C117(1.16); C161(1.31)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C117(1.01); C161(0.92)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C117(1.10)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C117(1.16); C161(0.97)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C117(1.10)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C117(0.91); C161(0.99)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C117(1.20)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C117(1.04); C161(0.89)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C117(1.02)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C117(0.89); C161(0.88)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C117(1.14)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C117(1.07)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C117(1.18); C161(0.93)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C117(1.14)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C117(0.96); C161(1.06)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C117(0.29)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C117(0.94); C161(0.97)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C117(0.98)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C117(0.79); C161(0.96)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C117(1.15)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C117(1.07); C161(0.98)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C117(1.01)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C117(0.92); C161(0.95)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C117(1.25)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C117(1.08); C161(1.00)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C117(0.91); C161(0.99)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C117(0.95); C161(0.98)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C117(0.93); C161(0.94)  LDD1611  [2]
 LDCM0411  CL23 HEK-293T C117(0.89); C161(1.22)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C117(0.83)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C117(0.83)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C117(0.91); C161(0.92)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C117(0.99)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C117(0.98); C161(1.00)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C117(0.95); C161(0.93)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C117(1.05)  LDD1622  [2]
 LDCM0420  CL31 HEK-293T C117(0.92); C161(1.15)  LDD1624  [2]
 LDCM0424  CL35 HEK-293T C117(0.91); C161(1.12)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C117(0.84)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C117(1.07)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C117(1.00)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C117(1.19); C161(1.28)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C117(1.04); C161(0.96)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C117(1.14); C161(1.02)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C117(0.88); C161(0.99)  LDD1637  [2]
 LDCM0437  CL47 HEK-293T C117(1.08); C161(1.10)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C117(1.22)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C117(0.99)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C117(0.99); C161(1.14)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C117(0.80); C161(1.10)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C117(0.94); C161(1.05)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C117(0.86); C161(1.09)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C117(1.01); C161(1.02)  LDD1649  [2]
 LDCM0450  CL59 HEK-293T C117(1.01); C161(1.08)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C117(0.75)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C117(0.74)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C117(0.89); C161(0.89)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C117(1.17)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C117(1.17); C161(1.06)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C117(0.84); C161(1.07)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C117(0.93); C161(0.98)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C117(1.32); C161(1.01)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C117(1.11); C161(1.07)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C117(0.81)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C117(1.04)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C117(0.89); C161(0.92)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C117(1.15); C161(1.04)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C117(1.14); C161(1.27)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C117(1.07); C161(1.00)  LDD1675  [2]
 LDCM0477  CL83 HEK-293T C117(1.00); C161(1.27)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C117(0.87)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C117(1.04)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C117(0.97); C161(0.94)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C117(1.40)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C117(1.21); C161(1.04)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C117(0.93); C161(1.01)  LDD1686  [2]
 LDCM0486  CL91 HEK-293T C117(1.00); C161(1.06)  LDD1689  [2]
 LDCM0490  CL95 HEK-293T C117(0.99); C161(0.93)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C117(0.87)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C117(1.12)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C117(0.77); C161(1.18)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C117(1.01)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C117(1.21)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C117(1.16)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C117(0.89); C161(0.94)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C161(1.14)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C161(0.99)  LDD1497  [2]
 LDCM0024  KB05 NCI-H1975 C85(4.81)  LDD3352  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402