Details of the Target

General Information of Target

Target ID LDTP17600
Target Name Zinc finger protein 761 (ZNF761)
Gene Name ZNF761
Gene ID 388561
Synonyms
KIAA2033; Zinc finger protein 761
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDKFRMLFQHFQSSSESVMNGICLLLAAVTVKLYSSFDFNCPCLVHYNALYGLGLLLTPP
LALFLCGLLANRQSVVMVEEWRRPAGHRRKDPGIIRYMCSSVLQRALAAPLVWILLALLD
GKCFVCAFSSSVDPEKFLDFANMTPSQVQLFLAKVPCKEDELVRDSPARKAVSRYLRCLS
QAIGWSVTLLLIIAAFLARCLRPCFDQTVFLQRRYWSNYVDLEQKLFDETCCEHARDFAH
RCVLHFFASMRSELQARGLRRGNAGRRLELPAVPEPPEGLDSGSGKAHLRAISSREQVDR
LLSTWYSSKPPLDLAASPGLCGGGLSHRAPTLALGTRLSQHTDV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q86XN6
Ensemble ID
ENST00000432094.6
HGNC ID
HGNC:23179

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C735(1.53)  LDD0666  [1]
IA-alkyne
 Probe Info  		C217(0.00); C455, C287, C623(0.00)  LDD0165  [2]
HHS-465
 Probe Info  		K296(0.00); K299(0.00); K492(0.00); K495(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0349  AC83 HCT 116 C735(1.53)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C735(1.66)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C735(1.45)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C735(1.24)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C735(1.11)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C735(1.09)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C735(1.23)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C735(1.06)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C735(1.47)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C735(1.42)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C735(1.24)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C735(1.41)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C735(1.19)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C735(1.37)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C735(1.52)  LDD0681  [1]
 LDCM0367  CL1 HCT 116 C735(1.01)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C735(0.57)  LDD0685  [1]
 LDCM0379  CL11 HCT 116 C735(0.88)  LDD0696  [1]
 LDCM0390  CL12 HCT 116 C735(0.65)  LDD0707  [1]
 LDCM0400  CL13 HCT 116 C735(0.80)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C735(0.77)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C735(0.78)  LDD0719  [1]
 LDCM0407  CL2 HCT 116 C735(1.14)  LDD0724  [1]
 LDCM0418  CL3 HCT 116 C735(1.15)  LDD0735  [1]
 LDCM0420  CL31 HCT 116 C735(0.79)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C735(0.67)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C735(0.85)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C735(0.78)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C735(0.96)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C735(0.80)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C735(0.99)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C735(0.73)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C735(1.44)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C735(0.67)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C735(0.80)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C735(0.70)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C735(0.59)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C735(0.58)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C735(0.54)  LDD0752  [1]
 LDCM0440  CL5 HCT 116 C735(0.92)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C735(0.75)  LDD0768  [1]
 LDCM0453  CL61 HCT 116 C735(1.00)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C735(0.87)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C735(0.91)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C735(1.25)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C735(1.13)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C735(0.95)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C735(0.92)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C735(0.67)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C735(1.49)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C735(0.79)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C735(0.79)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C735(0.82)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C735(0.88)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C735(0.91)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C735(0.98)  LDD0784  [1]
 LDCM0473  CL8 HCT 116 C735(0.88)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C735(0.70)  LDD0801  [1]
 LDCM0468  Fragment33 HCT 116 C735(1.01)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C735(1.01)  LDD0744  [1]
 LDCM0022  KB02 769-P C735(2.38)  LDD2246  [4]
 LDCM0023  KB03 769-P C735(1.61)  LDD2663  [4]
 LDCM0024  KB05 OS-RC-2 C735(4.49)  LDD3378  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840