Details of the Target

General Information of Target

Target ID LDTP17241
Target Name Growth hormone-regulated TBC protein 1 (GRTP1)
Gene Name GRTP1
Gene ID 79774
Synonyms
TBC1D6; Growth hormone-regulated TBC protein 1; TBC1 domain family member 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVVVAAAGGAGPAVLQVAGLYRGLCAVRSRALGLGLVSPAQLRVFPVRPGSGRPEGGA
DSSGVGAEAELQANPFYDRYRDKIQLLRRSDPAAFESRLEKRSEFRKQPVGHSRQGDFIK
CVEQKTDALGKQSVNRGFTKDKTLSSIFNIEMVKEKTAEEIKQIWQQYFAAKDTVYAVIP
AEKFDLIWNRAQSCPTFLCALPRREGYEFFVGQWTGTELHFTALINIQTRGEAAASQLIL
YHYPELKEEKGIVLMTAEMDSTFLNVAEAQCIANQVQLFYATDRKETYGLVETFNLRPNE
FKYMSVIAELEQSGLGAELKCAQNQNKT
Target Bioclass
Other
Function May act as a GTPase-activating protein for Rab family protein(s).
Uniprot ID
Q5TC63
Ensemble ID
ENST00000326039.3
HGNC ID
HGNC:20310

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.G54R .
AGS SNV: p.L276S .
JURKAT SNV: p.L225M .
KNS81FD SNV: p.Q149H .
OVTOKO SNV: p.R42K .
SAOS2 SNV: p.K308N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C54(2.50)  LDD3319  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C253(1.16)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C132(1.05)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C253(0.93)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C253(1.01); C132(0.98)  LDD1513  [3]
 LDCM0277  AC18 HEK-293T C253(1.05)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C132(0.85)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C253(1.14)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C253(0.89)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C253(0.97)  LDD1520  [3]
 LDCM0283  AC23 HEK-293T C253(1.21); C132(0.89)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C253(0.78)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C253(0.85)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C132(0.95)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C253(0.82)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C253(1.07)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C132(1.12)  LDD1529  [3]
 LDCM0292  AC31 HEK-293T C253(0.82); C132(0.95)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C253(0.76)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C253(0.80)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C132(0.95)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C253(0.85)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C253(1.12)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C253(1.14); C132(0.98)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C253(0.79)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C253(0.84)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C253(1.24)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C132(1.18)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C253(0.85)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C253(0.97)  LDD1546  [3]
 LDCM0309  AC47 HEK-293T C253(1.01); C132(0.99)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C253(0.81)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C253(0.88)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C253(0.94)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C132(1.03)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C253(0.98)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C253(0.89)  LDD1555  [3]
 LDCM0318  AC55 HEK-293T C253(1.02); C132(0.93)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C253(1.03)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C253(1.06)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C132(0.97)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C253(1.10)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C253(1.05)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C253(1.27); C132(0.92)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C253(0.83)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C253(0.93); C132(0.88)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C253(1.15)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C253(0.95)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C253(0.97)  LDD1514  [3]
 LDCM0371  CL102 HEK-293T C253(0.91)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C253(0.96)  LDD1576  [3]
 LDCM0375  CL106 HEK-293T C253(0.78)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C253(0.88)  LDD1580  [3]
 LDCM0379  CL11 HEK-293T C253(1.41); C132(1.11)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C253(1.00)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C253(0.96)  LDD1585  [3]
 LDCM0384  CL114 HEK-293T C253(0.77)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C253(0.85)  LDD1589  [3]
 LDCM0388  CL118 HEK-293T C253(0.94)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C253(1.04)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C253(1.45)  LDD1594  [3]
 LDCM0393  CL122 HEK-293T C253(0.82)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C253(0.91)  LDD1598  [3]
 LDCM0397  CL126 HEK-293T C253(0.73)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C253(1.03)  LDD1602  [3]
 LDCM0401  CL14 HEK-293T C253(1.10)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C253(1.10)  LDD1606  [3]
 LDCM0405  CL18 HEK-293T C253(1.01)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C132(1.12)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C253(1.12)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C253(1.19)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C253(1.09)  LDD1613  [3]
 LDCM0411  CL23 HEK-293T C253(1.29); C132(1.06)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C253(1.39)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C253(0.96)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C253(0.94)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C253(1.03)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C253(0.88)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C132(1.18)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C253(1.05)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C253(0.97)  LDD1626  [3]
 LDCM0424  CL35 HEK-293T C253(1.57); C132(1.03)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C253(1.19)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C253(0.73)  LDD1632  [3]
 LDCM0432  CL42 HEK-293T C253(0.94)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C132(1.09)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C253(1.08)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C253(1.38)  LDD1639  [3]
 LDCM0437  CL47 HEK-293T C253(1.21); C132(1.09)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C253(1.04)  LDD1642  [3]
 LDCM0441  CL50 HEK-293T C253(1.04)  LDD1645  [3]
 LDCM0445  CL54 HEK-293T C253(0.93)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C132(1.09)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C253(1.17)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C253(1.36)  LDD1651  [3]
 LDCM0450  CL59 HEK-293T C253(1.11); C132(1.11)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C253(1.36)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C253(1.71)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C253(0.90)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C253(1.04)  LDD1658  [3]
 LDCM0458  CL66 HEK-293T C253(0.85)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C132(1.12)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C253(1.15)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C253(1.42)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C132(1.41)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C253(1.22); C132(1.05)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C253(1.11)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C253(0.93)  LDD1670  [3]
 LDCM0471  CL78 HEK-293T C253(0.99)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C132(0.98)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C253(1.25)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C253(1.18)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C253(1.28)  LDD1678  [3]
 LDCM0477  CL83 HEK-293T C253(0.93); C132(1.19)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C253(1.30)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C253(1.28)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C253(1.16)  LDD1684  [3]
 LDCM0484  CL9 HEK-293T C253(1.42)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C253(1.06)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C132(1.09)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C253(0.99)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C253(1.44)  LDD1691  [3]
 LDCM0490  CL95 HEK-293T C253(1.12); C132(1.04)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C253(1.29)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C253(1.07)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C253(0.85)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C253(1.09)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C253(0.99)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C253(0.93)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C132(0.96); C253(0.76)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C132(1.03); C253(1.04)  LDD1497  [3]
 LDCM0024  KB05 MEWO C54(2.50)  LDD3319  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402