Details of the Target

General Information of Target

Target ID LDTP17114
Target Name Uncharacterized aarF domain-containing protein kinase 5 (ADCK5)
Gene Name ADCK5
Gene ID 203054
Synonyms
Uncharacterized aarF domain-containing protein kinase 5; EC 2.7.11.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALTQGPLKFMDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLGICLPDLSVTSML
EQKRDPWTLQSEEKIANDPDGRECIKGVNTERSSKLGSNAGNKPCKNQLGFTFQLHLSDL
QLFQAERKISGCKHFEKPVSDNSSVSPLEKISSSVKSHLLNKYRNNFDHAPLLPQEQKAH
IREKAYKCNEHGQVFRASASLTNQVIHNADNPYKCSECGKVFSCSSKLVIHRRMHTGEKP
YKCHECGKLFSSNSNLSQHQRIHTGEKPYKCHECDKVFRSSSKLAQHQRIHTGEKPYKCH
ECDKVFNQIAHLVRHQKIHTGEKPYSCNKCGKVFSRHSYLAEHQTVHTGEKPYKCEECGK
AFSVRSSLITHQLIHTGRKPYKCKECDKVFGRKCFLTSHQRIHTRERPYGCSQCGKIFSQ
KSDLIRHRKTHTDEKPYKCNKCGTAFREFSDLTAHFLIHSGEKPYECKECGKVFRYKSSL
TSHHRIHTGEKPYKCNRCGKVFSRSSNLVCHQKIHTGEKPYKCNQCGKVFNQASYLTRHQ
IIHTGERPYRCSKCGKAFRGCSGLTAHLAIHTEKKSHECKECGKIFTQKSSLTNHHRIHI
GEKPYKCTLCSKVFSHNSDLAQHQRVHS
Target Bioclass
Enzyme
Family
Protein kinase superfamily, ADCK protein kinase family
Subcellular location
Membrane
Function The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Uniprot ID
Q3MIX3
Ensemble ID
ENST00000308860.11
HGNC ID
HGNC:21738
ChEMBL ID
CHEMBL4105886

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C398(0.28)  LDD1093  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C398(0.28)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C398(1.50)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C398(1.24)  LDD1105  [1]
 LDCM0237  AC12 PaTu 8988t C398(1.10)  LDD1116  [1]
 LDCM0259  AC14 PaTu 8988t C398(1.19)  LDD1138  [1]
 LDCM0263  AC143 PaTu 8988t C398(0.98)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C398(0.89)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C398(1.06)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C398(1.02)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C398(0.99)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C398(0.86)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C398(1.29)  LDD1148  [1]
 LDCM0270  AC15 PaTu 8988t C398(1.34)  LDD1149  [1]
 LDCM0271  AC150 PaTu 8988t C398(0.94)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C398(1.13)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C398(0.92)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C398(1.36)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C398(0.85)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C398(0.83)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C398(1.40)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C398(0.96)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C398(0.95)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C398(1.04)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C398(0.95)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C398(0.29)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C398(0.99)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C398(1.13)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C398(1.15)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C398(0.92)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C398(0.81)  LDD1163  [1]
 LDCM0290  AC3 PaTu 8988t C398(0.33)  LDD1169  [1]
 LDCM0296  AC35 PaTu 8988t C398(1.01)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C398(1.70)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C398(1.03)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C398(0.91)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C398(0.88)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C398(0.49)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C398(1.32)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C398(1.31)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C398(0.96)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C398(1.50)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C398(1.03)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C398(1.14)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C398(1.49)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C398(0.77)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C398(0.90)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C398(1.21)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C398(0.23)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C398(1.20)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C398(1.24)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C398(0.99)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C398(1.15)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C398(1.24)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C398(0.90)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C398(0.96)  LDD1198  [1]
 LDCM0323  AC6 PaTu 8988t C398(1.43)  LDD1202  [1]
 LDCM0332  AC68 PaTu 8988t C398(0.91)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C398(0.96)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C398(0.96)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C398(0.92)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C398(1.00)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C398(1.02)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C398(1.16)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C398(1.00)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C398(1.61)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C398(0.90)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C398(1.16)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C398(1.06)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C398(1.18)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C398(0.90)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C398(1.23)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C398(1.15)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C398(1.03)  LDD1227  [1]
 LDCM0349  AC83 PaTu 8988t C398(0.90)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C398(0.95)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C398(1.00)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C398(1.09)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C398(1.08)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C398(1.00)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C398(0.95)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C398(0.76)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C398(0.84)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C398(1.12)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C398(0.94)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C398(0.99)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C398(0.86)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C398(0.83)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C398(0.94)  LDD1243  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C398(1.29)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C398(1.34)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C398(1.30)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C398(1.00)  LDD2171  [1]
 LDCM0369  CL100 PaTu 8988t C398(0.20)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C398(1.21)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C398(1.44)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C398(1.19)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C398(1.08)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C398(0.92)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C398(0.84)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C398(0.95)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C398(0.91)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C398(0.94)  LDD1257  [1]
 LDCM0380  CL110 PaTu 8988t C398(0.92)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C398(0.97)  LDD1260  [1]
 LDCM0387  CL117 PaTu 8988t C398(1.19)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C398(1.58)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C398(1.12)  LDD1268  [1]
 LDCM0391  CL120 PaTu 8988t C398(0.98)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C398(1.24)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C398(2.37)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C398(0.90)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C398(1.20)  LDD1274  [1]
 LDCM0420  CL31 PaTu 8988t C398(1.50)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C398(2.08)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C398(1.28)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C398(1.52)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C398(1.28)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C398(1.18)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C398(2.25)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C398(0.91)  LDD1307  [1]
 LDCM0430  CL40 PaTu 8988t C398(1.52)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C398(1.34)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C398(1.25)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C398(2.43)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C398(2.29)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C398(1.55)  LDD1314  [1]
 LDCM0469  CL76 PaTu 8988t C398(0.90)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C398(1.29)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C398(0.87)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C398(1.24)  LDD1351  [1]
 LDCM0474  CL80 PaTu 8988t C398(2.20)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C398(1.02)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C398(1.11)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C398(1.10)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C398(1.42)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C398(1.13)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C398(0.94)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C398(0.85)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C398(0.90)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C398(0.96)  LDD1362  [1]
 LDCM0485  CL90 PaTu 8988t C398(0.94)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C398(0.28)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C398(0.35)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C398(0.30)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C398(0.24)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C398(0.24)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C398(0.31)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C398(0.24)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C398(0.23)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C398(0.31)  LDD1373  [1]
 LDCM0427  Fragment51 PaTu 8988t C398(2.08)  LDD1306  [1]
 LDCM0022  KB02 BRX29 C398(2.89)  LDD2270  [2]
 LDCM0023  KB03 BRX394 C398(5.12)  LDD2691  [2]
 LDCM0024  KB05 BRX29 C398(2.77)  LDD3104  [2]
 LDCM0021  THZ1 HCT 116 C398(1.00)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840