Details of the Target

General Information of Target

Target ID LDTP16818
Target Name Zinc finger protein 780A (ZNF780A)
Gene Name ZNF780A
Gene ID 284323
Synonyms
Zinc finger protein 780A
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPE
EVCERSSSEETLNNVGDAETPGTVSPNLLLDGQLAAAAAAPANGGGVVSARSVSGALAST
LAAAATSAPAPGAPGGPQLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRGRW
TCMEYYERDSDSSVLTRSGDCIRHSSTFDQTAERDSGLGATGGSVVVVVASMQGAHGPES
GTDSSLTAVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAAT
GPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYP
QPQIPPGHLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNAS
SVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQS
VPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQ
LSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEP
LPQPPLSLIAENKPVVKPPVADSLANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFY
QAFHLNTLKESKSLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELV
ERNSLLERENALLKSLSSNDQLSQLPTQQANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
O75290
Ensemble ID
ENST00000340963.9
HGNC ID
HGNC:27603

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.E393D .
CMK SNV: p.L248V; p.R511Ter .
DU145 SNV: p.G357S .
MCC26 SNV: p.E190K .
MFE319 SNV: p.Q131H .
NCIH2052 SNV: p.I107K .
TOV21G SNV: p.G553E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C458(0.99)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C458(1.03)  LDD1512  [1]
 LDCM0282  AC22 HEK-293T C458(1.08)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C458(0.97)  LDD1523  [1]
 LDCM0291  AC30 HEK-293T C458(0.87)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C458(1.21)  LDD1532  [1]
 LDCM0299  AC38 HEK-293T C458(1.04)  LDD1538  [1]
 LDCM0302  AC40 HEK-293T C458(0.99)  LDD1541  [1]
 LDCM0308  AC46 HEK-293T C458(1.08)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C458(1.03)  LDD1549  [1]
 LDCM0317  AC54 HEK-293T C458(1.08)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C458(1.03)  LDD1558  [1]
 LDCM0323  AC6 HEK-293T C458(0.97)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C458(0.99)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C458(1.06)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C458(1.05)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C458(1.04)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C458(1.18)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C458(1.17)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C458(1.06)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C458(1.15)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C458(1.17)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C458(1.07)  LDD1590  [1]
 LDCM0390  CL12 HEK-293T C458(1.08)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C458(1.12)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C458(1.12)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C458(1.20)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C458(1.16)  LDD1607  [1]
 LDCM0410  CL22 HEK-293T C458(1.02)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C458(1.11)  LDD1616  [1]
 LDCM0416  CL28 HEK-293T C458(1.25)  LDD1620  [1]
 LDCM0423  CL34 HEK-293T C458(0.93)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C458(0.98)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C458(1.11)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C458(0.99)  LDD1634  [1]
 LDCM0436  CL46 HEK-293T C458(0.97)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C458(1.03)  LDD1642  [1]
 LDCM0443  CL52 HEK-293T C458(1.06)  LDD1646  [1]
 LDCM0449  CL58 HEK-293T C458(1.03)  LDD1652  [1]
 LDCM0452  CL60 HEK-293T C458(1.08)  LDD1655  [1]
 LDCM0456  CL64 HEK-293T C458(0.99)  LDD1659  [1]
 LDCM0463  CL70 HEK-293T C458(1.12)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C458(0.97)  LDD1668  [1]
 LDCM0469  CL76 HEK-293T C458(1.12)  LDD1672  [1]
 LDCM0476  CL82 HEK-293T C458(0.93)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C458(1.20)  LDD1681  [1]
 LDCM0482  CL88 HEK-293T C458(1.01)  LDD1685  [1]
 LDCM0489  CL94 HEK-293T C458(1.02)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C458(1.11)  LDD1694  [1]
 LDCM0022  KB02 HEK-293T C458(0.99)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C458(0.91)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C458(0.87)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402