Details of the Target

General Information of Target

Target ID LDTP16237
Target Name Ataxin-7-like protein 1 (ATXN7L1)
Gene Name ATXN7L1
Gene ID 222255
Synonyms
ATXN7L4; KIAA1218; Ataxin-7-like protein 1; Ataxin-7-like protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNN
ASGVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPASLQRGLHRQALAFHFCKAQDSDT
LCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGM
KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSK
AVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSS
GCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAA
CRPLTITELYHAVWTKNMSLTLEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKH
CTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGT
PVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQ
CDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGC
GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV
LNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC
VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN
GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE
NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL
ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT
MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA
WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT
AMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGS
TGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTAT
AQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKP
SLKSTKASKGGKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPK
QMPAESQCKIMIPSAQQEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVS
VPRTMQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL
Target Bioclass
Other
Uniprot ID
Q9ULK2
Ensemble ID
ENST00000318724.8
HGNC ID
HGNC:22210

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.E497Ter .
CAL78 SNV: p.T720N .
EFO27 SNV: p.I263V .
HCC1954 SNV: p.N704D .
HT115 SNV: p.R489Ter .
IGR1 SNV: p.S661F .
LS180 SNV: p.K779R .
MEWO SNV: p.I408L .
MFE296 SNV: p.R848Ter .
MOLT4 SNV: p.A465V .
SBC5 SNV: p.P195R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C193(1.00)  LDD1492  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]
IPM
 Probe Info  		C193(0.00); C58(0.00)  LDD2156  [3]
Phosphinate-6
 Probe Info  		C193(0.00); C790(0.00)  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C193(1.20)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C193(1.09)  LDD1508  [1]
 LDCM0259  AC14 HEK-293T C193(0.91)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C193(1.13)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C193(0.94)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C193(1.17)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C193(1.13)  LDD1518  [1]
 LDCM0282  AC22 HEK-293T C193(1.02)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C193(1.08)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C193(1.06)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C193(1.37)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C193(0.95)  LDD1525  [1]
 LDCM0291  AC30 HEK-293T C193(0.98)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C193(1.05)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C193(0.97)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C193(1.20)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C193(1.13)  LDD1534  [1]
 LDCM0299  AC38 HEK-293T C193(1.06)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C193(1.25)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C193(1.16)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C193(1.03)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C193(1.13)  LDD1543  [1]
 LDCM0308  AC46 HEK-293T C193(1.17)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C193(0.98)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C193(1.02)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C193(1.32)  LDD1550  [1]
 LDCM0313  AC50 HEK-293T C193(1.06)  LDD1552  [1]
 LDCM0317  AC54 HEK-293T C193(1.03)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C193(1.08)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C193(1.10)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C193(1.17)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C193(1.30)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C193(1.16)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C193(1.14)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C193(0.95)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C193(1.26)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C193(0.96)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C193(1.21)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C193(1.18)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C193(1.01)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C193(1.05)  LDD1572  [1]
 LDCM0371  CL102 HEK-293T C193(1.20)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C193(0.98)  LDD1576  [1]
 LDCM0375  CL106 HEK-293T C193(0.96)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C193(0.85)  LDD1580  [1]
 LDCM0379  CL11 HEK-293T C193(1.04)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C193(0.86)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C193(1.29)  LDD1585  [1]
 LDCM0384  CL114 HEK-293T C193(0.99)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C193(0.88)  LDD1589  [1]
 LDCM0388  CL118 HEK-293T C193(1.14)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C193(1.09)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C193(0.98)  LDD1594  [1]
 LDCM0393  CL122 HEK-293T C193(1.03)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C193(0.99)  LDD1598  [1]
 LDCM0397  CL126 HEK-293T C193(1.04)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C193(0.94)  LDD1602  [1]
 LDCM0401  CL14 HEK-293T C193(0.96)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C193(0.91)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C193(1.31)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C193(1.11)  LDD1609  [1]
 LDCM0407  CL2 HEK-293T C193(0.98)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C193(1.18)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C193(0.96)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C193(0.80)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C193(1.21)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C193(1.03)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C193(1.33)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C193(0.90)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C193(1.15)  LDD1623  [1]
 LDCM0423  CL34 HEK-293T C193(0.72)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C193(1.02)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C193(0.93)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C193(0.91)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C193(1.36)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C193(1.09)  LDD1636  [1]
 LDCM0436  CL46 HEK-293T C193(0.86)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C193(0.99)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C193(0.77)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C193(1.39)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C193(0.94)  LDD1645  [1]
 LDCM0444  CL53 HEK-293T C193(1.57)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C193(0.88)  LDD1648  [1]
 LDCM0449  CL58 HEK-293T C193(0.98)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C193(1.08)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C193(1.08)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C193(0.87)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C193(1.20)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C193(0.97)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C193(1.05)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C193(1.20)  LDD1661  [1]
 LDCM0463  CL70 HEK-293T C193(1.11)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C193(0.87)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C193(0.99)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C193(0.93)  LDD1670  [1]
 LDCM0470  CL77 HEK-293T C193(0.74)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C193(1.30)  LDD1674  [1]
 LDCM0476  CL82 HEK-293T C193(1.06)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C193(0.90)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C193(0.83)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C193(0.80)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C193(0.95)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C193(1.11)  LDD1686  [1]
 LDCM0485  CL90 HEK-293T C193(1.26)  LDD1688  [1]
 LDCM0489  CL94 HEK-293T C193(0.83)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C193(1.00)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C193(0.88)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C193(0.88)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C193(1.02)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C193(0.94)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C193(0.95)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C193(0.81)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C193(1.00)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C193(0.98)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C193(0.87)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PHD finger protein 1 (PHF1) Polycomblike family O43189
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Gelsolin (GSN) Villin/gelsolin family P06396
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004