Details of the Target

General Information of Target

Target ID LDTP16177
Target Name Protocadherin-10 (PCDH10)
Gene Name PCDH10
Gene ID 57575
Synonyms
KIAA1400; Protocadherin-10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTKAEQFASKIRYLQEYHNRVLHNIYPVPSGTDIANTLKYFSQTLLSILSRTGKKENQD
ASNLTVPMTMCLFPVPFPLTPSLRPQVSSINPTVTRSLLYSVLRDAPSERGPQSRDAQLS
DYPSLDYQGLYVTLVTLLDLVPLLQHGQHDLGQSIFYTTTCLLPFLNDDILSTLPYTMIS
TLATFPPFLHKDIIEYLSTSFLPMAILGSSRREGVPAHVNLSASSMLMIAMQYTSNPVYH
CQLLECLMKYKQEVWKDLLYVIAYGPSQVKPPAVQMLFHYWPNLKPPGAISEYRGLQYTA
WNPIHCQHIECHNAINKPAVKMCIDPSLSVALGDKPPPLYLCEECSERIAGDHSEWLIDV
LLPQAEISAICQKKNCSSHVRRAVVTCFSAGCCGRHGNRPVRYCKRCHSNHHSNEVGAAA
ETHLYQTSPPPINTRECGAEELVCAVEAVISLLKEAEFHAEQREHELNRRRQLGLSSSHH
SLDNADFDNKDDDKHDQRLLSQFGIWFLVSLCTPSENTPTESLARLVAMVFQWFHSTAYM
MDDEVGSLVEKLKPQFVTKWLKTVCDVRFDVMVMCLLPKPMEFARVGGYWDKSCSTVTQL
KEGLNRILCLIPYNVINQSVWECIMPEWLEAIRTEVPDNQLKEFREVLSKMFDIELCPLP
FSMEEMFGFISCRFTGYPSSVQEQALLWLHVLSELDIMVPLQLLISMFSDGVNSVKELAN
QRKSRVSELAGNLASRRVSVASDPGRRVQHNMLSPFHSPFQSPFRSPLRSPFRSPFKNFG
HPGGRTIDFDCEDDEMNLNCFILMFDLLLKQMELQDDGITMGLEHSLSKDIISIINNVFQ
APWGGSHTCQKDEKAIECNLCQSSILCYQLACELLERLAPKEESRLVEPTDSLEDSLLSS
RPEFIIGPEGEEEENPASKHGENPGNCTEPVEHAAVKNDTERKFCYQQLPVTLRLIYTIF
QEMAKFEEPDILFNMLNCLKILCLHGECLYIARKDHPQFLAYIQDHMLIASLWRVVKSEF
SQLSSLAVPLLLHALSLPHGADIFWTIINGNFNSKDWKMRFEAVEKVAVICRFLDIHSVT
KNHLLKYSLAHAFCCFLTAVEDVNPAVATRAGLLLDTIKRPALQGLCLCLDFQFDTVVKD
RPTILSKLLLLHFLKQDIPALSWEFFVNRFETLSLEAQLHLDCNKEFPFPTTITAVRTNV
ANLSDAALWKIKRARFARNRQKSVRSLRDSVKGPVESKRALSLPETLTSKIRQQSPENDN
TIKDLLPEDAGIDHQTVHQLITVLMKFMAKDESSAESDISSAKAFNTVKRHLYVLLGYDQ
QEGCFMIAPQKMRLSTCFNAFIAGIAQVMDYNINLGKHLLPLVVQVLKYCSCPQLRHYFQ
QPPRCSLWSLKPHIRQMWLKALLVILYKYPYRDCDISKILLHLIHITVNTLNAQYHSCKP
HATAGPLYSDNSNISRYSEKEKGEIELAEYRETGALQDSLLHCVREESIPKKKLRSFKQK
SLDIGNADSLLFTLDEHRRKSCIDRCDIEKPPTQAAYIAQRPNDPGRSRQNSATRPDNSE
IPENPAMEGFPDARRPVIPEVRLNCMETFEVKVDSPVKPAPKEDLDLIDLSSDSTSGPEK
HSILSTSDSDSLVFEPLPPLRIVESDEEEETMNQGDDGPSGKNAASSPSVPSHPSVLSLS
TAPLVQVSVEDCSKDFSSKDSGNNQSAGNTDSALITLEDPMDAEGSSKPEELPEFSCGSP
LTLKQKRDLLQKSFALPEMSLDDHPDPGTEGEKPGELMPSSGAKTVLLKVPEDAENPTES
EKPDTSAESDTEQNPERKVEEDGAEESEFKIQIVPRQRKQRKIAVSAIQREYLDISFNIL
DKLGEQKDPDPSTKGLSTLEMPRESSSAPTLDAGVPETSSHSSISTQYRQMKRGSLGVLT
MSQLMKRQLEHQSSAPHNISNWDTEQIQPGKRQCNVPTCLNPDLEGQPLRMRGATKSSLL
SAPSIVSMFVPAPEEFTDEQPTVMTDKCHDCGAILEEYDEETLGLAIVVLSTFIHLSPDL
AAPLLLDIMQSVGRLASSTTFSNQAESMMVPGNAAGVAKQFLRCIFHQLAPNGIFPQLFQ
STIKDGTFLRTLASSLMDFNELSSIAALSQLLEGLNNKKNLPAGGAMIRCLENIATFMEA
LPMDSPSSLWTTISNQFQTFFAKLPCVLPLKCSLDSSLRIMICLLKIPSTNATRSLLEPF
SKLLSFVIQNAVFTLAYLVELCGLCYRAFTKERDKFYLSRSVVLELLQALKLKSPLPDTN
LLLLVQFICADAGTKLAESTILSKQMIASVPGCGTAAMECVRQYINEVLDFMADMHTLTK
LKSHMKTCSQPLHEDTFGGHLKVGLAQIAAMDISRGNHRDNKAVIRYLPWLYHPPSAMQQ
GPKEFIECVSHIRLLSWLLLGSLTHNAVCPNASSPCLPIPLDAGSHVADHLIVILIGFPE
QSKTSVLHMCSLFHAFIFAQLWTVYCEQSAVATNLQNQNEFSFTAILTALEFWSRVTPSI
LQLMAHNKVMVEMVCLHVISLMEALQECNSTIFVKLIPMWLPMIQSNIKHLSAGLQLRLQ
AIQNHVNHHSLRTLPGSGQSSAGLAALRKWLQCTQFKMAQVEIQSSEAASQFYPL
Target Bioclass
Other
Subcellular location
Cell membrane
Function Potential calcium-dependent cell-adhesion protein.
Uniprot ID
Q9P2E7
Ensemble ID
ENST00000264360.7
HGNC ID
HGNC:13404

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A372V .
CCK81 SNV: p.L758I .
COLO792 SNV: p.M978I .
DU145 SNV: p.F106L .
DU4475 SNV: p.V857I .
HCT116 SNV: p.V683M .
HCT15 SNV: p.G208C; p.Y327H; p.A366V; p.K406N; p.A558T .
HEC1 SNV: p.R157H .
HT SNV: p.V606A .
HT29 SNV: p.R423Q .
ICC9 SNV: p.S444F .
Ishikawa (Heraklio) 02 ER SNV: p.I905M .
LS513 SNV: p.A351S .
MCAS SNV: p.V212L .
MCC13 SNV: p.K1037N .
MEWO SNV: p.P89S; p.E186G; p.S243F .
MFE319 SNV: p.A274T; p.Q993R .
MINO SNV: p.G689C .
NALM6 SNV: p.A203V .
NB1 SNV: p.D126E .
NCIH1703 Substitution: p.T846K DBIA    Probe Info 
NCIH358 SNV: p.Q172H .
RKO SNV: p.V472M .
SUPT1 SNV: p.R157H .
SW480 SNV: p.L48F .
YSCCC SNV: p.Q677Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C953(1.37)  LDD3342  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C953(0.95)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C953(0.87)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C953(1.16)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C953(0.83)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C953(1.43)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C953(0.75)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C953(1.04)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C953(0.98)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C953(1.05)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C953(0.76)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C953(0.82)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C953(1.24)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C953(1.01); C395(0.96)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C953(0.81)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C953(0.86)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C953(0.74)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C953(0.81)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C953(0.96)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C953(1.24)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C953(1.09)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C953(1.12); C395(1.11)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C953(0.78)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C953(0.99)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C953(0.97)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C953(0.92)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C953(1.08)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C953(1.44)  LDD1538  [3]
 LDCM0301  AC4 HEK-293T C953(0.91)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C953(1.22); C395(1.16)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C953(0.98)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C953(0.96)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C953(1.47)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C953(1.05)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C953(1.08)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C953(1.05)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C953(1.41); C395(1.32)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C953(0.70)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C953(0.91)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C953(0.93)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C953(0.81)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C953(1.38)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C953(1.28)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C953(1.49)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C953(1.11); C395(0.96)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C953(1.03)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C953(1.12)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C953(0.82)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C953(1.07)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C953(1.28)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C953(1.26)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C953(1.11)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C953(1.08); C395(0.93)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C953(0.97); C395(0.81)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C953(0.83)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C953(0.81)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C953(1.09); C395(1.09)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C953(1.19)  LDD1572  [3]
 LDCM0390  CL12 HEK-293T C953(1.31); C395(1.02)  LDD1594  [3]
 LDCM0404  CL17 HEK-293T C953(0.31)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C953(1.09)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C953(1.50)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C953(1.19)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C953(1.02)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C953(1.04)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C953(0.92); C395(1.00)  LDD1616  [3]
 LDCM0417  CL29 HEK-293T C953(1.00)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C953(0.78)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C953(0.77)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C953(1.17)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C953(1.00)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C953(0.24)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C953(0.86); C395(0.98)  LDD1629  [3]
 LDCM0431  CL41 HEK-293T C953(2.40)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C953(0.84)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C953(0.77)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C953(0.83)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C953(1.22)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C953(1.02)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C953(0.87); C395(0.89)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C953(0.72)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C953(0.66)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C953(1.32)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C953(0.96)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C953(1.12)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C953(0.94)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C953(1.85)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C953(1.30)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C953(1.09); C395(0.93)  LDD1655  [3]
 LDCM0457  CL65 HEK-293T C953(0.75)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C953(1.02)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C953(1.18)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C953(1.09)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C953(1.24)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C953(0.77)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C953(1.60)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C953(1.23); C395(1.23)  LDD1668  [3]
 LDCM0470  CL77 HEK-293T C953(0.84)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C953(0.86)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C953(1.10)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C953(0.55)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C953(1.40)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C953(1.17)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C953(0.95)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C953(1.18); C395(1.20)  LDD1681  [3]
 LDCM0483  CL89 HEK-293T C953(0.84)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C953(0.94)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C953(0.79)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C953(0.64)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C953(0.56)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C953(0.87)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C953(1.36)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C953(0.95); C395(0.90)  LDD1694  [3]
 LDCM0022  KB02 A673 C953(1.07)  LDD2261  [1]
 LDCM0023  KB03 A204 C953(1.13)  LDD2669  [1]
 LDCM0024  KB05 NCI-H1155 C953(1.37)  LDD3342  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402