Details of the Target

General Information of Target

Target ID LDTP16159
Target Name JNK1/MAPK8-associated membrane protein (JKAMP)
Gene Name JKAMP
Gene ID 51528
Synonyms
C14orf100; JAMP; JNK1/MAPK8-associated membrane protein; JKAMP; JNK1-associated membrane protein; JAMP; Medulloblastoma antigen MU-MB-50.4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPVRRSAKWRPGGIEARGEGVSTVGYRNKNVRQKTWRPNHPQAFVGSVREGQGFAFRRK
LKIQQSYKKLLRKEKKAQTSLESQFTDRYPDNLKHLYLAEEERHRKQARKVDHPLSEQVH
QPLLEEQCSIDEPLFEDQCSFDQPQPEEQCIKTVNSFTIPKKNKKKTSNQKAQEEYEQIQ
AKRAAKKQEFERRKQEREEAQRQYKKKKMEVFKILNKKTKKGQPNLNVQMEYLLQKIQEK
C
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
Regulates the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system.
Uniprot ID
Q9P055
Ensemble ID
ENST00000356057.9
HGNC ID
HGNC:20184

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C189(1.99)  LDD1700  [1]
IA-alkyne
 Probe Info  		C181(0.52)  LDD2183  [2]
IPM
 Probe Info  		C189(7.55)  LDD1701  [1]
DBIA
 Probe Info  		C196(0.86)  LDD1155  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C189(0.88)  LDD2117  [1]
 LDCM0276  AC17 PaTu 8988t C196(0.86)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C196(1.04)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C196(0.81)  LDD1157  [3]
 LDCM0280  AC20 PaTu 8988t C196(1.01)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C196(1.19)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C196(1.10)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C196(1.15)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C196(0.94)  LDD1163  [3]
 LDCM0296  AC35 PaTu 8988t C196(0.71)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C196(0.93)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C196(0.82)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C196(0.67)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C196(0.71)  LDD1179  [3]
 LDCM0302  AC40 PaTu 8988t C196(0.93)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C196(0.90)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C196(1.03)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C196(1.19)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C196(1.31)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C196(1.40)  LDD1186  [3]
 LDCM0367  CL1 PaTu 8988t C196(0.80)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C196(0.95)  LDD1247  [3]
 LDCM0372  CL103 HEK-293T C181(1.01)  LDD1576  [4]
 LDCM0374  CL105 PaTu 8988t C196(0.84)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C196(0.85)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C196(0.92)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C196(1.11)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C196(0.86)  LDD1257  [3]
 LDCM0379  CL11 PaTu 8988t C196(0.84)  LDD1258  [3]
 LDCM0380  CL110 PaTu 8988t C196(1.12)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C196(1.63)  LDD1260  [3]
 LDCM0385  CL115 HEK-293T C181(0.98)  LDD1589  [4]
 LDCM0387  CL117 PaTu 8988t C196(0.71)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C196(0.74)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C196(0.90)  LDD1268  [3]
 LDCM0390  CL12 PaTu 8988t C196(1.18)  LDD1269  [3]
 LDCM0391  CL120 PaTu 8988t C196(0.96)  LDD1270  [3]
 LDCM0394  CL123 HEK-293T C181(1.30)  LDD1598  [4]
 LDCM0398  CL127 HEK-293T C181(0.99)  LDD1602  [4]
 LDCM0400  CL13 PaTu 8988t C196(0.68)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C196(0.83)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C196(1.02)  LDD1281  [3]
 LDCM0407  CL2 PaTu 8988t C196(1.15)  LDD1286  [3]
 LDCM0415  CL27 HEK-293T C181(1.00)  LDD1619  [4]
 LDCM0418  CL3 PaTu 8988t C196(0.97)  LDD1297  [3]
 LDCM0420  CL31 PaTu 8988t C196(1.44)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C196(1.92)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C196(1.33)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C196(2.16)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C196(1.86)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C196(1.35)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C196(2.99)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C196(1.65)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C196(0.77)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C196(1.47)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C196(2.08)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C196(2.13)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C196(3.59)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C196(2.03)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C196(1.10)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C196(0.74)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C196(0.90)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C196(0.81)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C196(0.79)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C196(0.76)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C196(0.78)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C196(1.09)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C196(0.85)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C196(0.89)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C196(0.76)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C196(0.76)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C196(0.80)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C196(0.80)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C196(0.74)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C196(0.78)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C196(0.56)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C196(0.92)  LDD1331  [3]
 LDCM0455  CL63 HEK-293T C181(0.88)  LDD1658  [4]
 LDCM0462  CL7 PaTu 8988t C196(0.74)  LDD1341  [3]
 LDCM0473  CL8 PaTu 8988t C196(0.60)  LDD1352  [3]
 LDCM0481  CL87 HEK-293T C181(1.06)  LDD1684  [4]
 LDCM0484  CL9 PaTu 8988t C196(1.00)  LDD1363  [3]
 LDCM0494  CL99 HEK-293T C181(0.98)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C181(1.00)  LDD1698  [4]
 LDCM0625  F8 Ramos C181(0.53)  LDD2187  [2]
 LDCM0573  Fragment11 Ramos C181(1.42)  LDD2190  [2]
 LDCM0582  Fragment23 Ramos C181(2.32)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C181(0.72)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C181(0.86)  LDD2198  [2]
 LDCM0468  Fragment33 HEK-293T C181(0.97)  LDD1671  [4]
 LDCM0427  Fragment51 PaTu 8988t C196(1.31)  LDD1306  [3]
 LDCM0614  Fragment56 Ramos C181(2.70)  LDD2205  [2]
 LDCM0023  KB03 MDA-MB-231 C189(7.55)  LDD1701  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C189(1.04)  LDD2099  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C189(0.79)  LDD2109  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C189(1.00)  LDD2136  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C189(1.99)  LDD1700  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C189(0.78)  LDD2140  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein YIPF6 (YIPF6) YIP1 family Q96EC8

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402