Details of the Target

General Information of Target

Target ID LDTP16011
Target Name Mth938 domain-containing protein (AAMDC)
Gene Name AAMDC
Gene ID 28971
Synonyms
C11orf67; Mth938 domain-containing protein; Adipogenesis associated Mth938 domain-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVTGITILFWPLSMILLSDKIQSSKREVQCNFTEKNYTLIPADIKKDVTILDLSYNQIT
LNGTDTRVLQTYFLLTELYLIENKVTILHNNGFGNLSSLEILNICRNSIYVIQQGAFLGL
NKLKQLYLCQNKIEQLNADVFVPLRSLKLLNLQGNLISYLDVPPLFHLELITLYGNLWNC
SCSLFNLQNWLNTSNVTLENENITMCSYPNSLQSYNIKTVPHKAECHSKFPSSVTEDLYI
HFQPISNSIFNSSSNNLTRNSEHEPLGKSWAFLVGVVVTVLTTSLLIFIAIKCPIWYNIL
LSYNHHRLEEHEAETYEDGFTGNPSSLSQIPETNSEETTVIFEQLHSFVVDDDGFIEDKY
IDIHELCEEN
Target Bioclass
Other
Family
AAMDC family
Subcellular location
Cytoplasm
Function May play a role in preadipocyte differentiation and adipogenesis.
Uniprot ID
Q9H7C9
Ensemble ID
ENST00000393427.7
HGNC ID
HGNC:30205

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 Deletion: p.G32VfsTer23 .
LS180 SNV: p.Y23C .
NCIH1048 SNV: p.T22A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K86(10.00); K87(4.38)  LDD0277  [1]
Probe 1
 Probe Info  		Y84(26.82)  LDD3495  [2]
BTD
 Probe Info  		C26(0.50)  LDD2096  [3]
DBIA
 Probe Info  		C122(1.28)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		7.50  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C122(0.53)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C122(0.91)  LDD1094  [4]
 LDCM0216  AC100 PaTu 8988t C122(1.38)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C122(0.95)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C122(1.00)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C122(1.41)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C122(1.00)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C122(0.97)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C122(1.40)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C122(0.94)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C122(0.97)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C122(0.89)  LDD1104  [4]
 LDCM0226  AC11 PaTu 8988t C122(1.12)  LDD1105  [4]
 LDCM0227  AC110 PaTu 8988t C122(1.13)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C122(1.07)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C122(1.35)  LDD1108  [4]
 LDCM0237  AC12 PaTu 8988t C122(1.06)  LDD1116  [4]
 LDCM0259  AC14 PaTu 8988t C122(0.73)  LDD1138  [4]
 LDCM0270  AC15 PaTu 8988t C122(1.07)  LDD1149  [4]
 LDCM0276  AC17 PaTu 8988t C122(1.08)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C122(1.33)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C122(1.00)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C122(0.52)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C122(1.08)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C122(1.25)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C122(1.33)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C122(1.36)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C122(1.30)  LDD1163  [4]
 LDCM0285  AC25 PaTu 8988t C122(1.20)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C122(1.34)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C122(1.20)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C122(1.29)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C122(1.27)  LDD1168  [4]
 LDCM0290  AC3 PaTu 8988t C122(0.89)  LDD1169  [4]
 LDCM0291  AC30 PaTu 8988t C122(1.32)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C122(0.94)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C122(1.07)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C122(1.33)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C122(2.04)  LDD1174  [4]
 LDCM0296  AC35 PaTu 8988t C122(0.85)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C122(1.06)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C122(0.98)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C122(0.98)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C122(1.18)  LDD1179  [4]
 LDCM0301  AC4 PaTu 8988t C122(0.75)  LDD1180  [4]
 LDCM0302  AC40 PaTu 8988t C122(1.30)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C122(0.97)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C122(1.15)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C122(1.54)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C122(1.22)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C122(1.24)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C122(0.95)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C122(1.00)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C122(1.24)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C122(1.27)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C122(0.69)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C122(1.17)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C122(0.56)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C122(1.32)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C122(1.24)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C122(1.62)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C122(1.05)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C122(1.26)  LDD1198  [4]
 LDCM0321  AC58 HEK-293T C122(1.10)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C122(1.31)  LDD1561  [8]
 LDCM0323  AC6 PaTu 8988t C122(0.91)  LDD1202  [4]
 LDCM0332  AC68 PaTu 8988t C122(1.12)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C122(1.11)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C122(0.86)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C122(0.80)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C122(1.05)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C122(1.17)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C122(0.89)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C122(0.85)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C122(1.04)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C122(1.09)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C122(1.06)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C122(1.03)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C122(0.83)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C122(0.98)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C122(0.94)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C122(1.33)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C122(1.25)  LDD1227  [4]
 LDCM0349  AC83 PaTu 8988t C122(0.84)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C122(0.78)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C122(0.80)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C122(0.66)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C122(0.76)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C122(1.11)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C122(0.92)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C122(0.89)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C122(0.98)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C122(0.91)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C122(0.87)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C122(0.77)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C122(1.08)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C122(0.80)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C122(0.84)  LDD1243  [4]
 LDCM0365  AC98 PaTu 8988t C122(1.05)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C122(0.90)  LDD1245  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C26(0.69)  LDD2113  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C122(0.97)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C122(0.90)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C122(1.30)  LDD1154  [4]
 LDCM0369  CL100 PaTu 8988t C122(0.62)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C122(0.93)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C122(0.89)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C122(1.14)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C122(0.94)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C122(1.02)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C122(0.98)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C122(1.09)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C122(1.05)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C122(1.09)  LDD1257  [4]
 LDCM0380  CL110 PaTu 8988t C122(1.17)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C122(1.52)  LDD1260  [4]
 LDCM0382  CL112 PaTu 8988t C122(1.10)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C122(1.14)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C122(1.07)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C122(1.07)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C122(1.20)  LDD1265  [4]
 LDCM0387  CL117 PaTu 8988t C122(0.93)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C122(0.77)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C122(0.99)  LDD1268  [4]
 LDCM0391  CL120 PaTu 8988t C122(0.93)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C122(0.91)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C122(1.14)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C122(1.43)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C122(1.27)  LDD1274  [4]
 LDCM0405  CL18 HEK-293T C122(1.13)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C122(1.06)  LDD1610  [8]
 LDCM0419  CL30 HEK-293T C122(1.11)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C122(1.22)  LDD1624  [8]
 LDCM0432  CL42 HEK-293T C122(1.00)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C122(1.32)  LDD1637  [8]
 LDCM0445  CL54 HEK-293T C122(1.09)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C122(1.16)  LDD1649  [8]
 LDCM0451  CL6 HEK-293T C122(1.08)  LDD1654  [8]
 LDCM0453  CL61 PaTu 8988t C122(0.95)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C122(1.07)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C122(1.16)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C122(1.23)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C122(1.17)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C122(1.22)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C122(1.37)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C122(1.14)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C122(1.50)  LDD1340  [4]
 LDCM0462  CL7 HEK-293T C122(1.04)  LDD1665  [8]
 LDCM0463  CL70 PaTu 8988t C122(1.19)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C122(1.20)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C122(1.12)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C122(1.20)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C122(1.08)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C122(1.03)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C122(1.23)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C122(1.50)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C122(1.23)  LDD1351  [4]
 LDCM0474  CL80 PaTu 8988t C122(1.05)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C122(1.68)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C122(1.23)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C122(1.45)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C122(1.28)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C122(1.44)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C122(1.76)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C122(1.38)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C122(1.52)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C122(1.48)  LDD1362  [4]
 LDCM0485  CL90 PaTu 8988t C122(1.37)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C122(0.64)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C122(0.40)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C122(0.67)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C122(0.52)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C122(0.53)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C122(0.52)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C122(0.45)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C122(0.57)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C122(0.54)  LDD1373  [4]
 LDCM0468  Fragment33 PaTu 8988t C122(1.34)  LDD1347  [4]
 LDCM0022  KB02 HCT 116 C122(1.28)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C122(1.14)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C122(1.12)  LDD0082  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C26(0.50)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C26(0.75)  LDD2097  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C26(0.75)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C26(0.72)  LDD2124  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C26(0.43)  LDD2134  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (ACY3) AspA/AstE family Q96HD9
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
VPS9 domain-containing protein 1 (VPS9D1) . Q9Y2B5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402