Details of the Target

General Information of Target

Target ID LDTP16000
Target Name Zinc finger protein 576 (ZNF576)
Gene Name ZNF576
Gene ID 79177
Synonyms
Zinc finger protein 576
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRSCSAVGCSTRDTVLSRERGLSFHQFPTDTIQRSKWIRAVNRVDPRSKKIWIPGPGAI
LCSKHFQESDFESYGIRRKLKKGAVPSVSLYKIPQGVHLKGKARQKILKQPLPDNSQEVA
TEDHNYSLKTPLTIGAEKLAEVQQMLQVSKKRLISVKNYRMIKKRKGLRLIDALVEEKLL
SEETECLLRAQFSDFKWELYNWRETDEYSAEMKQFACTLYLCSSKVYDYVRKILKLPHSS
ILRTWLSKCQPSPGFNSNIFSFLQRRVENGDQLYQYCSLLIKSMPLKQQLQWDPSSHSLQ
GFMDFGLGKLDADETPLASETVLLMAVGIFGHWRTPLGYFFVNRASGYLQAQLLRLTIGK
LSDIGITVLAVTSDATAHSVQMAKALGIHIDGDDMKCTFQHPSSSSQQIAYFFDSCHLLR
LIRNAFQNFQSIQFINGIAHWQHLVELVALEEQELSNMERIPSTLANLKNHVLKVNSATQ
LFSESVASALEYLLSLDLPPFQNCIGTIHFLRLINNLFDIFNSRNCYGKGLKGPLLPETY
SKINHVLIEAKTIFVTLSDTSNNQIIKGKQKLGFLGFLLNAESLKWLYQNYVFPKVMPFP
YLLTYKFSHDHLELFLKMLRQVLVTSSSPTCMAFQKAYYNLETRYKFQDEVFLSKVSIFD
ISIARRKDLALWTVQRQYGVSVTKTVFHEEGICQDWSHCSLSEALLDLSDHRRNLICYAG
YVANKLSALLTCEDCITALYASDLKASKIGSLLFVKKKNGLHFPSESLCRVINICERVVR
THSRMAIFELVSKQRELYLQQKILCELSGHINLFVDVNKHLFDGEVCAINHFVKLLKDII
ICFLNIRAKNVAQNPLKHHSERTDMKTLSRKHWSSVQDYKCSSFANTSSKFRHLLSNDGY
PFK
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9H609
Ensemble ID
ENST00000336564.5
HGNC ID
HGNC:28357

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C29(1.54)  LDD2188  [1]
DBIA
 Probe Info  		C29(1.08)  LDD1507  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
VSF
 Probe Info  		N.A.  LDD0007  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C29(1.08)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C29(0.96)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C29(0.90)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C29(1.15)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C29(1.03)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C29(1.62)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C29(0.97)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C29(1.13)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C29(0.98)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C29(0.95)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C29(1.07)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C29(1.04)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C29(0.94)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C29(1.34)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C29(1.04)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C29(1.05)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C29(1.11)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C29(1.06)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C29(0.88)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C29(1.01)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C29(1.13)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C29(0.95)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C29(0.99)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C29(1.11)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C29(0.93)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C29(1.15)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C29(0.96)  LDD1550  [2]
 LDCM0314  AC51 HEK-293T C29(0.93)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C29(1.10)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C29(0.96)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C29(1.04)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C29(1.02)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C29(0.89)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C29(1.08)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C29(1.32)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C29(0.85)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C29(1.35)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C29(1.02)  LDD1569  [2]
 LDCM0356  AKOS034007680 HEK-293T C29(1.15)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C29(1.03)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C29(0.90)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C29(0.84)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C29(1.12)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C29(0.93)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C29(1.01)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C29(0.96)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C29(0.98)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C29(0.94)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C29(0.91)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C29(1.02)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C29(0.96)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C29(1.05)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C29(1.01)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C29(1.10)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C29(1.03)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C29(1.01)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C29(1.06)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C29(1.06)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C29(1.08)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C29(1.00)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C29(0.87)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C29(0.89)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C29(0.97)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C29(0.92)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C29(1.01)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C29(1.02)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C29(0.87)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C29(1.05)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C29(0.98)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C29(1.17)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C29(0.96)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C29(1.03)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C29(0.92)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C29(0.86)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C29(1.08)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C29(0.94)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C29(0.98)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C29(0.94)  LDD1622  [2]
 LDCM0420  CL31 HEK-293T C29(1.01)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C29(0.99)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C29(1.25)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C29(0.94)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C29(1.00)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C29(1.06)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C29(1.13)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C29(0.88)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C29(1.02)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C29(1.08)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C29(0.97)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C29(0.82)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C29(0.92)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C29(0.99)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C29(1.00)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C29(1.04)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C29(1.23)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C29(1.23)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C29(0.94)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C29(0.82)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C29(1.08)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C29(1.02)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C29(0.97)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C29(1.12)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C29(0.95)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C29(0.94)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C29(1.05)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C29(0.97)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C29(0.95)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C29(1.06)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C29(1.18)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C29(0.93)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C29(0.90)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C29(0.92)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C29(0.81)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C29(0.99)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C29(0.81)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C29(0.90)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C29(0.98)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C29(0.98)  LDD1686  [2]
 LDCM0486  CL91 HEK-293T C29(0.88)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C29(1.02)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C29(0.96)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C29(0.84)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C29(1.11)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C29(0.98)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C29(1.04)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C29(1.29)  LDD1698  [2]
 LDCM0574  Fragment12 Ramos C29(3.04)  LDD2191  [1]
 LDCM0579  Fragment20 Ramos C29(1.79)  LDD2194  [1]
 LDCM0586  Fragment28 Ramos C29(0.91)  LDD2198  [1]
 LDCM0468  Fragment33 HEK-293T C29(1.14)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C29(1.01)  LDD1631  [2]
 LDCM0571  Fragment9 Ramos C29(1.54)  LDD2188  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex subunit beta-1 (AP4B1) Adaptor complexes large subunit family Q9Y6B7
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin-related protein 2/3 complex subunit 3 (ARPC3) ARPC3 family O15145
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Prefoldin subunit 3 (VBP1) Prefoldin subunit alpha family P61758
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Melanoma-associated antigen 4 (MAGEA4) . P43358
PRKCA-binding protein (PICK1) . Q9NRD5
Protein phosphatase 1 regulatory subunit 27 (PPP1R27) . Q86WC6

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764