Details of the Target

General Information of Target

Target ID LDTP15836
Target Name Insulinoma-associated protein 2 (INSM2)
Gene Name INSM2
Gene ID 84684
Synonyms
IA6; Insulinoma-associated protein 2; Zinc finger protein IA-6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPPLSKRNPPALRLADLATAQVQPLQNMTGFPALAGPPAHSQLRAAVAHLRLRDLGADP
GVATTPLGPEHMAQASTLGLSPPSQAFPAHPEAPAAAARAAALVAHPGAGSYPCGGGSSG
AQPSAPPPPAPPLPPTPSPPPPPPPPPPPALSGYTTTNSGGGGSSGKGHSRDFVLRRDLS
ATAPAAAMHGAPLGGEQRSGTGSPQHPAPPPHSAGMFISASGTYAGPDGSGGPALFPALH
DTPGAPGGHPHPLNGQMRLGLAAAAAAAAAELYGRAEPPFAPRSGDAHYGAVAAAAAAAL
HGYGAVNLNLNLAAAAAAAAAGPGPHLQHHAPPPAPPPPPAPAQHPHQHHPHLPGAAGAF
LRYMRQPIKQELICKWIDPDELAGLPPPPPPPPPPPPPPPAGGAKPCSKTFGTMHELVNH
VTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFAR
SENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRGCDKSYTH
PSSLRKHMKIHCKSPPPSPGPLGYSSVGTPVGAPLSPVLDPARSHSSTLSPQVTNLNEWY
VCQASGAPSHLHTPSSNGTTSETEDEEIYGNPEVVRTIH
Target Bioclass
Transcription factor
Subcellular location
Cytoplasm
Function May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.
Uniprot ID
Q96T92
Ensemble ID
ENST00000307169.4
HGNC ID
HGNC:17539

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C77(1.81); C306(3.22)  LDD3433  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C547(0.86)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C547(0.93)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C547(1.08)  LDD1512  [2]
 LDCM0276  AC17 HEK-293T C547(0.94)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C547(0.73)  LDD1517  [2]
 LDCM0281  AC21 HEK-293T C547(0.91)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C547(1.11)  LDD1521  [2]
 LDCM0284  AC24 HEK-293T C547(1.11)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C547(0.83)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C547(1.01)  LDD1526  [2]
 LDCM0289  AC29 HEK-293T C547(1.02)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C547(1.02)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C547(1.09)  LDD1530  [2]
 LDCM0293  AC32 HEK-293T C547(1.03)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C547(0.85)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C547(1.07)  LDD1535  [2]
 LDCM0298  AC37 HEK-293T C547(1.09)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C547(1.11)  LDD1538  [2]
 LDCM0302  AC40 HEK-293T C547(1.14)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C547(0.86)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C547(1.00)  LDD1544  [2]
 LDCM0307  AC45 HEK-293T C547(1.02)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C547(1.15)  LDD1547  [2]
 LDCM0310  AC48 HEK-293T C547(1.11)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C547(0.83)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C547(1.12)  LDD1551  [2]
 LDCM0314  AC51 HEK-293T C547(0.97)  LDD1553  [2]
 LDCM0316  AC53 HEK-293T C547(0.92)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C547(1.02)  LDD1556  [2]
 LDCM0319  AC56 HEK-293T C547(0.98)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C547(0.75)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C547(1.00)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C547(1.03)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C547(0.93)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C547(0.92)  LDD1565  [2]
 LDCM0328  AC64 HEK-293T C547(0.94)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C547(1.09)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C547(0.97)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C547(0.80)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C547(1.03)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C547(0.84)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C547(2.24)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C547(0.85)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C547(0.78)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C547(0.80)  LDD1575  [2]
 LDCM0373  CL104 HEK-293T C547(0.91)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C547(0.87)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C547(0.98)  LDD1579  [2]
 LDCM0377  CL108 HEK-293T C547(0.86)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C547(1.01)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C547(0.83)  LDD1584  [2]
 LDCM0382  CL112 HEK-293T C547(0.88)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C547(1.04)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C547(0.97)  LDD1588  [2]
 LDCM0386  CL116 HEK-293T C547(0.91)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C547(0.87)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C547(0.88)  LDD1592  [2]
 LDCM0390  CL12 HEK-293T C547(2.26)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C547(1.08)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C547(0.81)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C547(0.84)  LDD1597  [2]
 LDCM0395  CL124 HEK-293T C547(0.81)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C547(0.57)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C547(0.74)  LDD1601  [2]
 LDCM0399  CL128 HEK-293T C547(0.80)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C547(0.56)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C547(0.85)  LDD1605  [2]
 LDCM0403  CL16 HEK-293T C547(1.01)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C547(0.72)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C547(1.14)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C547(0.71)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C547(1.76)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C547(2.35)  LDD1614  [2]
 LDCM0412  CL24 HEK-293T C547(2.39)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C547(0.62)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C547(0.82)  LDD1618  [2]
 LDCM0416  CL28 HEK-293T C547(0.93)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C547(1.08)  LDD1621  [2]
 LDCM0420  CL31 HEK-293T C547(1.15)  LDD1624  [2]
 LDCM0422  CL33 HEK-293T C547(1.65)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C547(2.31)  LDD1627  [2]
 LDCM0425  CL36 HEK-293T C547(2.79)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C547(0.73)  LDD1630  [2]
 LDCM0429  CL4 HEK-293T C547(0.77)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C547(1.12)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C547(1.09)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C547(1.72)  LDD1637  [2]
 LDCM0435  CL45 HEK-293T C547(1.61)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C547(2.85)  LDD1640  [2]
 LDCM0438  CL48 HEK-293T C547(2.64)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C547(0.68)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C547(0.71)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C547(0.94)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C547(1.06)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C547(0.90)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C547(1.44)  LDD1649  [2]
 LDCM0448  CL57 HEK-293T C547(2.04)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C547(2.45)  LDD1652  [2]
 LDCM0452  CL60 HEK-293T C547(2.48)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C547(0.72)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C547(0.91)  LDD1657  [2]
 LDCM0456  CL64 HEK-293T C547(0.94)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C547(0.92)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C547(1.44)  LDD1662  [2]
 LDCM0461  CL69 HEK-293T C547(1.61)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C547(1.15)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C547(2.36)  LDD1666  [2]
 LDCM0465  CL72 HEK-293T C547(1.79)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C547(0.72)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C547(0.78)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C547(0.92)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C547(0.82)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C547(1.28)  LDD1675  [2]
 LDCM0475  CL81 HEK-293T C547(1.38)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C547(2.26)  LDD1679  [2]
 LDCM0478  CL84 HEK-293T C547(1.73)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C547(0.62)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C547(0.68)  LDD1683  [2]
 LDCM0482  CL88 HEK-293T C547(0.72)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C547(0.67)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C547(1.66)  LDD1687  [2]
 LDCM0486  CL91 HEK-293T C547(0.92)  LDD1689  [2]
 LDCM0488  CL93 HEK-293T C547(1.43)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C547(1.76)  LDD1692  [2]
 LDCM0491  CL96 HEK-293T C547(1.32)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C547(0.73)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C547(1.02)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C547(1.03)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C547(0.99)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C547(0.91)  LDD1497  [2]
 LDCM0024  KB05 SK-N-AS C77(1.81); C306(3.22)  LDD3433  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402