Details of the Target

General Information of Target

Target ID LDTP15767
Target Name Ecto-ADP-ribosyltransferase 5 (ART5)
Gene Name ART5
Gene ID 116969
Synonyms
Ecto-ADP-ribosyltransferase 5; EC 2.4.2.31; ADP-ribosyltransferase C2 and C3 toxin-like 5; ARTC5; Mono(ADP-ribosyl)transferase 5; NAD(P)(+)--arginine ADP-ribosyltransferase 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPS
TTLVDRVFDESLNFQKIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEV
MGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSM
EISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPG
QTPTLGQPEARALHPAAVSAAAEFENAESEADFSIHFNRVNPDGEEEDVTVHK
Target Bioclass
Enzyme
Family
Arg-specific ADP-ribosyltransferase family
Subcellular location
Secreted
Uniprot ID
Q96L15
Ensemble ID
ENST00000359918.8
HGNC ID
HGNC:24049

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH2286 SNV: p.D77G .
OVCAR4 SNV: p.A5P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C150(0.94)  LDD0547  [1]
AOyne
 Probe Info  		15.00  LDD0443  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C150(0.94)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C150(0.91)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C150(1.08)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C150(1.46)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C150(1.40)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C150(1.05)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C150(1.13)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C150(1.14)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C150(0.88)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C150(1.10)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C150(0.96)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C150(0.95)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C150(1.00)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C150(0.84)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C150(1.08)  LDD0562  [1]
 LDCM0270  AC15 HEK-293T C150(0.91)  LDD1513  [3]
 LDCM0276  AC17 HCT 116 C150(1.10)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C150(0.89)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C150(1.06)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C150(1.10)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C150(0.97)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C150(0.86)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C150(1.14)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C150(1.13)  LDD0601  [1]
 LDCM0292  AC31 HEK-293T C150(1.00)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C150(1.03)  LDD1532  [3]
 LDCM0300  AC39 HEK-293T C150(1.04)  LDD1539  [3]
 LDCM0302  AC40 HEK-293T C150(1.10)  LDD1541  [3]
 LDCM0308  AC46 HCT 116 C150(1.23)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C150(1.27)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C150(1.15)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C150(1.34)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C150(1.42)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C150(1.12)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C150(1.51)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C150(1.01)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C150(0.95)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C150(0.98)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C150(1.13)  LDD0636  [1]
 LDCM0327  AC63 HEK-293T C150(0.95)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C150(1.04)  LDD1567  [3]
 LDCM0332  AC68 HCT 116 C150(1.03)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C150(2.53)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C150(1.01)  LDD1568  [3]
 LDCM0335  AC70 HCT 116 C150(1.47)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C150(1.08)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C150(1.27)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C150(1.61)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C150(1.12)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C150(1.63)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C150(1.04)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C150(1.37)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C150(1.70)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C150(1.56)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C150(1.01)  LDD1569  [3]
 LDCM0346  AC80 HCT 116 C150(1.14)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C150(1.40)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C150(1.09)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C150(0.67)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C150(0.74)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C150(0.86)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C150(0.74)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C150(0.66)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C150(0.78)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C150(0.65)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C150(0.59)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C150(0.71)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C150(0.38)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C150(0.75)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C150(0.61)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C150(0.89)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C150(0.58)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C150(0.61)  LDD0681  [1]
 LDCM0275  AKOS034007705 HEK-293T C150(0.97)  LDD1514  [3]
 LDCM0367  CL1 HCT 116 C150(0.85)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C150(1.26)  LDD0685  [1]
 LDCM0370  CL101 HEK-293T C150(0.97)  LDD1574  [3]
 LDCM0374  CL105 HCT 116 C150(0.89)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C150(0.83)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C150(1.11)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C150(0.93)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C150(0.97)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C150(1.26)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C150(1.16)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C150(1.29)  LDD0698  [1]
 LDCM0383  CL113 HEK-293T C150(1.08)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C150(1.08)  LDD1591  [3]
 LDCM0390  CL12 HCT 116 C150(0.95)  LDD0707  [1]
 LDCM0392  CL121 HCT 116 C150(1.03)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C150(1.09)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C150(0.75)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C150(1.12)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C150(1.03)  LDD1600  [3]
 LDCM0400  CL13 HCT 116 C150(1.03)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C150(1.24)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C150(1.30)  LDD0719  [1]
 LDCM0407  CL2 HCT 116 C150(1.08)  LDD0724  [1]
 LDCM0411  CL23 HEK-293T C150(1.07)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C150(1.08)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C150(1.35)  LDD1617  [3]
 LDCM0418  CL3 HCT 116 C150(1.35)  LDD0735  [1]
 LDCM0424  CL35 HEK-293T C150(1.09)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C150(1.14)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C150(1.03)  LDD1630  [3]
 LDCM0429  CL4 HCT 116 C150(1.24)  LDD0746  [1]
 LDCM0437  CL47 HEK-293T C150(1.07)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C150(1.18)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C150(1.09)  LDD1643  [3]
 LDCM0440  CL5 HCT 116 C150(1.18)  LDD0757  [1]
 LDCM0450  CL59 HEK-293T C150(1.09)  LDD1653  [3]
 LDCM0451  CL6 HCT 116 C150(0.77)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C150(1.15)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C150(0.96)  LDD1656  [3]
 LDCM0462  CL7 HCT 116 C150(0.90)  LDD0779  [1]
 LDCM0464  CL71 HEK-293T C150(1.10)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C150(1.12)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C150(1.23)  LDD1669  [3]
 LDCM0473  CL8 HCT 116 C150(1.15)  LDD0790  [1]
 LDCM0477  CL83 HEK-293T C150(1.20)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C150(1.31)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C150(1.06)  LDD1682  [3]
 LDCM0484  CL9 HCT 116 C150(1.06)  LDD0801  [1]
 LDCM0490  CL95 HEK-293T C150(1.88)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C150(1.38)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C150(1.01)  LDD1695  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402