Details of the Target

General Information of Target

Target ID LDTP15139
Target Name TATA box-binding protein-like 2 (TBPL2)
Gene Name TBPL2
Gene ID 387332
Synonyms
TBP2; TRF3; TATA box-binding protein-like 2; TBP-like 2; TATA box-binding protein-related factor 3; TBP-related factor 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPWRAGNGVGLEAQAGTQEAGPEEYCQEELGAEEEMAARAAWPVLRSVNSRELSRIIICN
HSPRIVLPVWLNYYGKLLPYLTLLPGRDFRIHNFRSHPWLFRDARTHDKLLVNQTELFVP
SSNVNGQPVFANITLQCIP
Target Bioclass
Transcription factor
Family
TBP family
Subcellular location
Cytoplasm
Function
Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.
Uniprot ID
Q6SJ96
Ensemble ID
ENST00000247219.6
HGNC ID
HGNC:19841

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C258(0.76)  LDD0532  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C258(0.76)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C258(0.69)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C258(1.09)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C258(1.03)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C258(1.03)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C258(1.36)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C258(1.16)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C258(1.17)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C258(1.17)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C258(0.84)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C258(0.79)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C258(1.47)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C258(1.08)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C258(0.96)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C258(1.41)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C258(0.96)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C258(1.17)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C258(1.18)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C258(0.65)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C258(0.78)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C258(1.09)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C258(0.88)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C258(0.82)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C258(0.91)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C258(0.87)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C258(0.93)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C258(0.89)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C258(0.95)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C258(1.33)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C258(0.78)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C258(1.20)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C258(1.44)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C258(0.95)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C258(0.74)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C258(0.95)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C258(1.14)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C258(0.85)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C258(0.92)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C258(1.17)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C258(1.07)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C258(0.99)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C258(1.05)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C258(1.22)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C258(1.16)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C258(1.17)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C258(1.32)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C258(1.07)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C258(1.27)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C258(1.29)  LDD0624  [1]
 LDCM0323  AC6 HCT 116 C258(0.88)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C258(0.93)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C258(1.04)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C258(0.63)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C258(0.67)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C258(0.66)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C258(0.84)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C258(0.80)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C258(0.67)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C258(0.67)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C258(0.80)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C258(0.61)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C258(0.66)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C258(0.63)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C258(0.57)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C258(0.69)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C258(0.65)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C258(0.60)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C258(0.86)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C258(0.98)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C258(0.82)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C258(0.76)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C258(0.41)  LDD0685  [1]
 LDCM0370  CL101 HCT 116 C258(0.78)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C258(0.69)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C258(0.75)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C258(0.75)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C258(1.28)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C258(1.32)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C258(0.96)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C258(1.33)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C258(0.84)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C258(0.33)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C258(0.93)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C258(0.74)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C258(1.43)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C258(1.02)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C258(0.87)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C258(1.39)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C258(1.16)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C258(1.40)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C258(1.13)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C258(1.30)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C258(0.48)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C258(1.17)  LDD0708  [1]
 LDCM0400  CL13 HCT 116 C258(0.43)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C258(0.40)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C258(0.31)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C258(1.20)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C258(0.81)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C258(1.04)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C258(0.92)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C258(0.88)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C258(1.21)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C258(1.02)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C258(1.14)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C258(1.15)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C258(1.30)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C258(1.45)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C258(1.16)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C258(1.10)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C258(1.13)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C258(1.41)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C258(0.52)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C258(1.18)  LDD0736  [1]
 LDCM0429  CL4 HCT 116 C258(0.56)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C258(0.65)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C258(0.56)  LDD0768  [1]
 LDCM0462  CL7 HCT 116 C258(0.55)  LDD0779  [1]
 LDCM0473  CL8 HCT 116 C258(0.57)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C258(0.43)  LDD0801  [1]
 LDCM0022  KB02 22RV1 C258(3.46)  LDD2243  [4]
 LDCM0023  KB03 22RV1 C258(4.28)  LDD2660  [4]
 LDCM0024  KB05 Hs 936.T C258(2.45)  LDD3313  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840