Details of the Target

General Information of Target

Target ID LDTP14982
Target Name Torsin-2A (TOR2A)
Gene Name TOR2A
Gene ID 27433
Synonyms
TORP1; Torsin-2A; Torsin family 2 member A; Torsin-related protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPKKSVSKAGKELEVKKKGGKKEPVVAVEPPLAKEMKEFYHIQIRDLEDRLARYQRKWD
ELAVQEKMFRQEFEQLANNKKEIVAFLKRTLNQQVDEITDLNEQLQNLQLAKEMEKDAFE
AQLAQVRHEFQETKDQLTTENIILGGKLAALEEFRLQKEEVTDKFTLLEEQVRKQENEFR
DYAYNLEKKSVLDKDRLRKEIIQRVNLVANEFHKVTTNRMWETTKRAIKENNGITLQMAR
VSQQGMKLLQENEQLKGRQNNLCKQLELLENTQKVMARHKRGHQKIILMLTKKCQEQQQD
TKEAEELRLLLSQLEQRSLQLQVDNQALKSQRDQLSLQLEQQQVDLQRLQQELANEQKVR
ASLEAALVQATSFLQNILQMHRDEEDSDVDVTFQPWHKEMLQQLLVMLSSTVATRPQKAA
CPHQESQSHGPPKESRPSIQLPRTGSLLPQLSDITPYQPGDLGLVPRQVHIPPNPQDLRL
LSYITRVGTFRAHSSPEMRAPGSLKRLEKFSLPEVPLRPK
Target Bioclass
Other
Family
ClpA/ClpB family, Torsin subfamily
Subcellular location
Endoplasmic reticulum lumen
Uniprot ID
Q5JU69
Ensemble ID
ENST00000373281.8
HGNC ID
HGNC:11996

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.A290V .
MFE280 SNV: p.G98R .
OVK18 SNV: p.R233H .
SKOV3 SNV: p.L89I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C271(1.64)  LDD3338  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C35(0.86)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C41(0.92)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C35(0.82); C41(1.15)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C35(0.88); C41(1.23)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C35(0.77); C41(1.20)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C35(0.95); C41(1.47)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C35(0.81); C41(1.32)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C35(0.91); C41(1.10)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C35(1.70); C41(1.48)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C35(0.85); C41(1.59)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C35(1.21); C41(1.63)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C35(1.27); C41(1.59)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C41(0.91)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C35(1.22); C41(2.24)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C35(1.32); C41(2.09)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C35(0.99); C41(1.82)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C35(0.88); C41(0.79)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C35(0.69); C41(2.03)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C35(0.79); C41(1.33)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C35(0.67); C41(1.06)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C35(0.60); C41(1.33)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C35(0.56); C41(1.08)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C35(0.56); C41(1.40)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C41(0.75)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C35(0.60); C41(1.34)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C35(0.64); C41(1.13)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C35(0.72); C41(3.21)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C35(0.63); C41(2.24)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C35(0.63); C41(1.19)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C35(0.71); C41(2.34)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C35(0.86); C41(2.63)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C35(0.88); C41(1.65)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C41(1.02)  LDD0857  [3]
 LDCM0263  AC143 HEK-293T C35(0.77)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C35(1.00)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C35(0.97)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C35(1.00)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C35(1.10)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C35(0.90)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C35(0.84)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C41(1.05)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C35(0.96)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C35(0.88)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C35(0.86)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C35(0.95)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C35(0.94)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C35(0.88)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C35(1.03)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C35(1.52)  LDD2165  [3]
 LDCM0279  AC2 HEK-293T C35(0.78)  LDD0877  [3]
 LDCM0283  AC23 HEK-293T C153(1.35)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C35(0.78)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C35(0.61)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C35(0.67)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C35(0.81)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C35(0.68)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C35(0.82)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C35(0.56)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C35(0.74)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C35(0.68)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C35(0.64)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C35(0.77)  LDD0893  [3]
 LDCM0300  AC39 HEK-293T C153(1.29)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C35(0.96)  LDD0899  [3]
 LDCM0309  AC47 HEK-293T C153(1.32)  LDD1548  [4]
 LDCM0312  AC5 HEK-293T C35(0.76)  LDD0910  [3]
 LDCM0318  AC55 HEK-293T C153(1.33)  LDD1557  [4]
 LDCM0323  AC6 HEK-293T C41(0.81)  LDD0921  [3]
 LDCM0327  AC63 HEK-293T C153(1.36)  LDD1566  [4]
 LDCM0332  AC68 HEK-293T C35(0.92); C41(0.88)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C35(0.83); C41(0.85)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C41(0.91)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C35(0.98); C41(1.04)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C35(0.89); C41(1.05)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C35(0.82); C41(0.78)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C35(0.99); C41(0.89)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C35(0.72); C41(0.96)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C35(0.97); C41(0.86)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C35(0.93); C41(1.07)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C35(0.85); C41(0.87)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C35(0.94); C41(0.81)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C35(0.94); C41(1.01)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C41(1.12)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C35(0.98); C41(0.99)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C35(0.95); C41(0.99)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C35(1.20); C41(0.78)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C35(0.58); C41(0.87)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C35(0.41); C41(0.82)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C35(0.32); C41(0.75)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C35(0.35); C41(0.98)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C35(0.47); C41(1.08)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C35(0.35); C41(0.70)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C35(0.44); C41(0.81)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C35(0.57); C41(0.89)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C35(0.44); C41(1.09)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C35(0.34); C41(0.89)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C35(0.40); C41(0.81)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C35(0.47); C41(0.82)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C35(0.44); C41(0.94)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C35(0.31); C41(0.85)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C35(0.43); C41(1.07)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C35(1.21); C41(1.69)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C35(0.73); C41(1.96)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C41(0.93)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C41(1.10)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C41(1.13)  LDD0873  [3]
 LDCM0367  CL1 PaTu 8988t C35(0.93)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C35(1.07)  LDD1247  [3]
 LDCM0369  CL100 HEK-293T C35(0.67)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C41(0.98)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C41(0.96)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C41(0.84)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C41(0.70)  LDD0971  [3]
 LDCM0379  CL11 PaTu 8988t C35(1.02)  LDD1258  [3]
 LDCM0382  CL112 HEK-293T C35(0.69)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C35(0.66)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C35(0.57)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C35(0.75)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C35(0.56)  LDD0984  [3]
 LDCM0390  CL12 PaTu 8988t C35(1.37)  LDD1269  [3]
 LDCM0400  CL13 PaTu 8988t C35(1.16)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C35(1.29)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C35(1.13)  LDD1281  [3]
 LDCM0407  CL2 PaTu 8988t C35(1.03)  LDD1286  [3]
 LDCM0411  CL23 HEK-293T C153(1.46)  LDD1615  [4]
 LDCM0418  CL3 PaTu 8988t C35(0.96)  LDD1297  [3]
 LDCM0424  CL35 HEK-293T C153(1.24)  LDD1628  [4]
 LDCM0429  CL4 PaTu 8988t C35(1.06)  LDD1308  [3]
 LDCM0437  CL47 HEK-293T C153(1.77)  LDD1641  [4]
 LDCM0440  CL5 PaTu 8988t C35(1.20)  LDD1319  [3]
 LDCM0450  CL59 HEK-293T C153(1.13)  LDD1653  [4]
 LDCM0451  CL6 PaTu 8988t C35(0.92)  LDD1330  [3]
 LDCM0453  CL61 HEK-293T C35(0.83)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C35(0.80)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C35(0.82)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C35(0.95)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C35(0.85)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C35(0.84)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C35(1.03)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C35(0.69)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C35(1.02)  LDD1059  [3]
 LDCM0462  CL7 PaTu 8988t C35(1.26)  LDD1341  [3]
 LDCM0463  CL70 HEK-293T C35(0.97)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C35(0.90)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C35(0.83)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C35(0.71)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C35(0.66)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C35(1.22)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C35(1.51)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C35(2.92)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C35(1.29)  LDD1070  [3]
 LDCM0473  CL8 PaTu 8988t C35(1.02)  LDD1352  [3]
 LDCM0474  CL80 HEK-293T C35(2.19)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C35(1.56)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C35(1.07)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C35(0.89)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C35(2.00)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C35(1.59)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C35(1.92)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C35(1.06)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C35(1.12)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C35(1.63)  LDD1081  [3]
 LDCM0484  CL9 PaTu 8988t C35(1.00)  LDD1363  [3]
 LDCM0485  CL90 HEK-293T C35(1.02)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C35(0.73)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C35(0.81)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C35(0.97)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C35(0.74)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C35(0.80)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C35(0.88)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C35(0.98)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C35(0.90)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C35(1.66)  LDD1092  [3]
 LDCM0468  Fragment33 HEK-293T C35(0.58)  LDD1066  [3]
 LDCM0022  KB02 K052 C271(1.00)  LDD2427  [1]
 LDCM0023  KB03 MV4-11 C271(3.46)  LDD2921  [1]
 LDCM0024  KB05 MV4-11 C271(1.64)  LDD3338  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402